ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q97KI2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name HISX_CLOAB
Primary accession number Q97KI2
Secondary accession numbers None
Integrated into Swiss-Prot on March 25, 2003
Sequence was last modified on October 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 46)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: CA_C0937
From
Clostridium acetobutylicum [TaxID: 1488] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
DOI=10.1128/JB.183.16.4823-4838.2001; PubMed=11466286 [NCBI, ExPASy, EBI, Israel, Japan]
Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R.;
"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum.";
J. Bacteriol. 183:4823-4838(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE001437; AAK78913.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR F97015; F97015.
RefSeq NP_347573.1; -.
3D structure databases
HSSP P06988; 1K75. [HSSP ENTRY / PDB]
ModBase Q97KI2.
Enzyme and pathway databases
BioCyc CACE272562:CAC0937-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q97KI2.
Genome annotation databases
GeneID 1117120; -.
GenomeReviews AE001437_GR; CA_C0937.
KEGG cac:CAC0937; -.
NMPDR fig|272562.1.peg.1102; -.
Phylogenomic databases
HOGENOM Q97KI2; -.
Genome annotation databases
CMR Q97KI2; CA_C0937.
Other
ProtoNet Q97KI2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   431  431     Histidinol dehydrogenase. PRO_0000135756
ACT_SITE   329   329        Proton acceptor (By similarity). 
ACT_SITE   330   330        Proton acceptor (By similarity). 
METAL   261   261        Zinc (By similarity). 
METAL   264   264        Zinc (By similarity). 
METAL   363   363        Zinc (By similarity). 
METAL   422   422        Zinc (By similarity). 
BINDING   131   131        NAD (By similarity). 
BINDING   193   193        NAD (By similarity). 
BINDING   216   216        NAD (By similarity). 
BINDING   239   239        Substrate (By similarity). 
BINDING   261   261        Substrate (By similarity). 
BINDING   264   264        Substrate (By similarity). 
BINDING   330   330        Substrate (By similarity). 
BINDING   363   363        Substrate (By similarity). 
BINDING   417   417        Substrate (By similarity). 
BINDING   422   422        Substrate (By similarity). 
Sequence information
Length: 431 AA [This is the length of the unprocessed precursor] Molecular weight: 46930 Da [This is the MW of the unprocessed precursor] CRC64: 70AFA3CB1946DF19 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEDIIRIIQD GSLDGEKYFQ SLKERQGKEN AEIIKTVKFI IDNVKENGDK ALIEYTSKFD 

        70         80         90        100        110        120 
KVELQSIEVT KEEIKAAYSK VENDFICALK TAKENIEEYH SKQVQNSYVI TKENGIVMGR 

       130        140        150        160        170        180 
TVRGLDKVGI YVPGGTAAYP SSVIMNAVPA KVAGVNKIIM TTPPMKDGFV NPSILVAADL 

       190        200        210        220        230        240 
AGVDKIYKVG GAQAIAALAF GTETIDKVDK IVGPGNIFVA MAKKSVYGFV DIDMIAGPSE 

       250        260        270        280        290        300 
ILVISDETGN PKFIAADLMS QAEHDTLASS ILVTTSKELI GKVIEEIKLQ VEGLSRKEII 

       310        320        330        340        350        360 
LEALRNFGAI ILVDSISRAI EIGNVVAPEH LEIITPNPFE YLNDIKNAGS IFLGSYSPEP 

       370        380        390        400        410        420 
LGDYMAGPNH VLPTSGTARF SSPLSVDDFV KKSSYLYYSE KALRNVNDKV VKIAETEGLT 

       430 
AHANSIKVRF K
Q97KI2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by kr flag YPRC Korea Mirror sites: Australia Brazil Canada China Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!