[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, AND INTERACTION WITH BAI1.
TISSUE=Brain;
DOI=10.1006/bbrc.1998.8603; PubMed=9647739 [NCBI, ExPASy, EBI, Israel, Japan]
Shiratsuchi T.,
Futamura M.,
Oda K.,
Nishimori H.,
Nakamura Y.,
Tokino T.;
"Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1.";
Biochem. Biophys. Res. Commun. 247:597-604(1998).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4 AND 5), ALTERNATIVE SPLICING (ISOFORMS 6 AND 7), SUBCELLULAR LOCATION, PHOSPHORYLATION, AND TISSUE SPECIFICITY.
DOI=10.1006/excr.2002.5475; PubMed=11969287 [NCBI, ExPASy, EBI, Israel, Japan]
Laura R.P.,
Ross S.,
Koeppen H.,
Lasky L.A.;
"MAGI-1: a widely expressed, alternatively spliced tight junction protein.";
Exp. Cell Res. 275:155-170(2002).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] OF 150-826 (ISOFORMS 1/3), TISSUE SPECIFICITY, AND INTERACTION WITH DRPLA.
DOI=10.1006/mcne.1998.0677; PubMed=9647693 [NCBI, ExPASy, EBI, Israel, Japan]
Wood J.D.,
Yuan J.,
Margolis R.L.,
Colomer V.,
Duan K.,
Kushi J.,
Kaminsky Z.,
Kleiderlein J.J. Jr.,
Sharp A.H.,
Ross C.A.;
"Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.";
Mol. Cell. Neurosci. 11:149-160(1998).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] OF 152-371.
DOI=10.1074/jbc.272.23.14611; PubMed=9169421 [NCBI, ExPASy, EBI, Israel, Japan]
Pirozzi G.,
McConnell S.J.,
Uveges A.J.,
Carter J.M.,
Sparks A.B.,
Kay B.K.,
Fowlkes D.M.;
"Identification of novel human WW domain-containing proteins by cloning of ligand targets.";
J. Biol. Chem. 272:14611-14616(1997).
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[5]
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INTERACTION WITH SYNPO AND ACTN4.
DOI=10.1074/jbc.M203072200; PubMed=12042308 [NCBI, ExPASy, EBI, Israel, Japan]
Patrie K.M.,
Drescher A.J.,
Welihinda A.,
Mundel P.,
Margolis B.;
"Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.";
J. Biol. Chem. 277:30183-30190(2002).
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[6]
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INTERACTION WITH IGSF5.
DOI=10.1128/MCB.23.12.4267-4282.2003; PubMed=12773569 [NCBI, ExPASy, EBI, Israel, Japan]
Hirabayashi S.,
Tajima M.,
Yao I.,
Nishimura W.,
Mori H.,
Hata Y.;
"JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1.";
Mol. Cell. Biol. 23:4267-4282(2003).
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[7]
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INTERACTION WITH FCHSD2.
DOI=10.1038/sj.onc.1206996; PubMed=14627983 [NCBI, ExPASy, EBI, Israel, Japan]
Ohno H.,
Hirabayashi S.,
Kansaku A.,
Yao I.,
Tajima M.,
Nishimura W.,
Ohnishi H.,
Mashima H.,
Fujita T.,
Omata M.,
Hata Y.;
"Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains.";
Oncogene 22:8422-8431(2003).
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[8]
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INTERACTION WITH ACCN3.
DOI=10.1074/jbc.M405874200; PubMed=15317815 [NCBI, ExPASy, EBI, Israel, Japan]
Hruska-Hageman A.M.,
Benson C.J.,
Leonard A.S.,
Price M.P.,
Welsh M.J.;
"PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current.";
J. Biol. Chem. 279:46962-46968(2004).
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[9]
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INTERACTION WITH AMOT.
DOI=10.1074/jbc.M503915200; PubMed=16043488 [NCBI, ExPASy, EBI, Israel, Japan]
Bratt A.,
Birot O.,
Sinha I.,
Veitonmaeki N.,
Aase K.,
Ernkvist M.,
Holmgren L.;
"Angiomotin regulates endothelial cell-cell junctions and cell motility.";
J. Biol. Chem. 280:34859-34869(2005).
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- FUNCTION: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ACCN3 currents by modulating its expression at the cell surface (By similarity).
- SUBUNIT: Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4. Interacts with cytoplasmic domain of BAI1. Interacts via its WW domains with DRPLA. Interacts with ESAM, LRP2 and CXADR. May interact with CTNNB1. Interacts through its PDZ 1 domain with NET1 (By similarity). Interacts with ACCN3 and AMOT. Interacts with FCHSD2. Interacts with IGSF5/JAM4 and through its PDZ 2 and 3 domains with NPHS1 forming a tripartite complex (By similarity).
- INTERACTION:
P08588:ADRB1; NbExp=1; IntAct=EBI-924464, EBI-991009;
O94868:FCHSD2; NbExp=2; IntAct=EBI-924464, EBI-1215612;
O60333-3:KIF1B; NbExp=1; IntAct=EBI-924464, EBI-465669;
- SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane; Peripheral membrane protein. Note=Localizes to epithelial cells tight junctions.
- ALTERNATIVE PRODUCTS:
7 named isoforms [FASTA] produced by alternative splicing. Additional isoforms seem to exist.
| Name | 1 |
| Synonyms | MAGI-1C-alpha-beta1 |
| Isoform ID | Q96QZ7-1 |
| Note: No experimental confirmation available. |
| This is the isoform sequence displayed in this entry. |
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| | | | |
| Name | 6 |
| Synonyms | MAGI-1C-beta2 |
| Isoform ID | Q96QZ7-6 |
| Note: No experimental confirmation available. |
| Features which should be applied to build the isoform sequence: VSP_011664, VSP_011666, VSP_011667. |
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| Name | 7 |
| Synonyms | MAGI-1C-beta3 |
| Isoform ID | Q96QZ7-7 |
| Note: No experimental confirmation available. |
| Features which should be applied to build the isoform sequence: VSP_011664, VSP_011665. |
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- TISSUE SPECIFICITY: Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expressed in pancreas and brain.
- PTM: Phosphorylated.
- SIMILARITY: Contains 1 guanylate kinase-like domain.
- SIMILARITY: Contains 6 PDZ (DHR) domains.
- SIMILARITY: Contains 2 WW domains.
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