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UniProtKB/Swiss-Prot entry Q94511


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NDUS1_DROME
Primary accession number Q94511
Secondary accession number Q9W3H1
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on February 21, 2001 (Sequence version 3)
Annotations were last modified on    September 2, 2008 (Entry version 80)
Name and origin of the protein
Protein name NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [Precursor]
Synonyms EC 1.6.5.3
EC 1.6.99.3
Complex I-75kD
CI-75kD
Gene name
Name: ND75
ORFNames: CG2286
From
Drosophila melanogaster (Fruit fly) [TaxID: 7227] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
DOI=10.1126/science.287.5461.2185; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[2]
GENOME REANNOTATION.
PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan]
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-653.
TISSUE=Ovary;
DOI=10.1007/s004380050942; PubMed=10071211 [NCBI, ExPASy, EBI, Israel, Japan]
Caggese C., Ragone G., Perrini B., Moschetti R., de Pinto V., Caizzi R., Barsanti P.;
"Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database.";
Mol. Gen. Genet. 261:64-70(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE014298; AAF46356.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y09063; CAA70284.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_511083.1; -.
NP_727255.1; -.
UniGene Dm.6840
3D structure databases
ModBase Q94511.
Protein-protein interaction databases
DIP DIP:17348N; -.
Enzyme and pathway databases
BioCyc DMEL-XXX-02:DMEL-XXX-02-001065-MON; -.
DMEL-XXX-02:DMEL-XXX-02-001066-MON; -.
Organism-specific databases
FlyBase FBgn0017566; ND75.
Gene expression databases
ArrayExpress Q94511; -.
GermOnline CG2286; Drosophila melanogaster.
Family and domain databases
InterPro IPR006058; 2Fe2S_fd_BS.
IPR001041; Ferredoxin.
IPR006656; Mopterin_OxRdtase.
IPR000283; NADH_DHase_75KDa_su_CS.
IPR010228; NADH_quinone_OxRdtase_G.
IPR015405; NuoG_C.
Graphical view of domain structure.
Pfam PF09326; DUF1982; 1.
PF00111; Fer2; 1.
PF00384; Molybdopterin; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01973; NuoG; 1.
PROSITE PS00197; 2FE2S_FER_1; FALSE_NEG.
PS51085; 2FE2S_FER_2; 1.
PS00641; COMPLEX1_75K_1; 1.
PS00642; COMPLEX1_75K_2; 1.
PS00643; COMPLEX1_75K_3; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q94511.
Genome annotation databases
Ensembl CG2286; Drosophila melanogaster. [Contig view]
GeneID 31762; -.
KEGG dme:Dmel_CG2286; -.
Other
ProtoNet Q94511.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
2Fe-2S; 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Respiratory chain; Transit peptide; Transport; Ubiquinone.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
TRANSIT   1    27  27     Mitochondrion (By similarity). 
CHAIN   28   731  704     NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial. PRO_0000019971
DOMAIN   40   118  79     2Fe-2S ferredoxin-type. 
METAL   74    74        Iron-sulfur 1 (2Fe-2S) (By similarity). 
METAL   85    85        Iron-sulfur 1 (2Fe-2S) (By similarity). 
METAL   88    88        Iron-sulfur 1 (2Fe-2S) (By similarity). 
METAL   102   102        Iron-sulfur 1 (2Fe-2S) (By similarity). 
METAL   134   134        Iron-sulfur 2 (4Fe-4S); via pros nitrogen (By similarity). 
METAL   138   138        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   141   141        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   147   147        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   190   190        Iron-sulfur 3 (4Fe-4S) (By similarity). 
METAL   193   193        Iron-sulfur 3 (4Fe-4S) (By similarity). 
METAL   196   196        Iron-sulfur 3 (4Fe-4S) (By similarity). 
METAL   240   240        Iron-sulfur 3 (4Fe-4S) (By similarity). 
CONFLICT   65    65        Q -> L (in Ref. 3; CAA70284). 
CONFLICT   94    94        K -> N (in Ref. 3; CAA70284). 
CONFLICT   111   111        R -> P (in Ref. 3; CAA70284). 
CONFLICT   120   120        R -> P (in Ref. 3; CAA70284). 
CONFLICT   470   470        A -> S (in Ref. 3; CAA70284). 
CONFLICT   611   611        Q -> H (in Ref. 3; CAA70284). 
Sequence information
Length: 731 AA [This is the length of the unprocessed precursor] Molecular weight: 78630 Da [This is the MW of the unprocessed precursor] CRC64: B3CA26B56AFACBFD [This is a checksum on the sequence]
        10         20         30         40         50         60 
MIRAPLVKAL GALGSPTHQM ASRAVRTSAM VAQTPAKAPE KIEVFVDDIP VQVVPGTTVL 

        70         80         90        100        110        120 
QAAAQIGVEI PRFCYHERLA VAGNCRMCLV EVEKSPKPVA ACAMPVMKGW RIKTNSDLTR 

       130        140        150        160        170        180 
KAREGVMEFL LMNHPLDCPI CDQGGECDLQ DQAMAFGSDR SRFTDINYTG KRAVEDKDIG 

       190        200        210        220        230        240 
PLVKTIMTRC IHCTRCVRFA SEIAGVDDLG TTGRGNDMQI GTYVEKLFLT ELSGNVIDLC 

       250        260        270        280        290        300 
PVGALTNKPY SFVARPWEIR KVSSIDVLDA VGSNIVVSTR TNEVLRILPR ENEDVNEEWL 

       310        320        330        340        350        360 
ADKSRFACDG LKRQRLVAPM VRMPNGELQA VEWEGALIAV AKAIKAAGGQ IAGISGQLAD 

       370        380        390        400        410        420 
LEAQVALKDL LNRLGSEVVA TEQGFIAGGT DNRANYLLNS TIAGLEEADA VLLVGTNPRY 

       430        440        450        460        470        480 
EAPLVNTRLR KAYVHNELQI ASIGPKIDLS YDHENLGADA ALVKDVCSGA HAFSKVLEGA 

       490        500        510        520        530        540 
KKPAIIIGAD LLERADGAAI HATVAEYCKK LKKPNWNPFN VLQTNAAQVG ALDVGYKAGA 

       550        560        570        580        590        600 
QTAVKAQPKV LFLLNADAGK VTREQLPKDC FVVYIGSHGD NGASIADAVL PGAAYTEKQG 

       610        620        630        640        650        660 
IYVNTEGRPQ QTLPGVSPPG MAREDWKILR ALSEVVGKPL PYDNLDELRN RLEDVAPHLT 

       670        680        690        700        710        720 
RLGQLEPAGD AGAAGTISKS IGGGAIDIKL KELRDYFMTD AISRASPTMA KCISAVNKQQ 

       730 
RENEAKQSVA I 

Q94511 in FASTA format

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