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UniProtKB/Swiss-Prot entry Q93873

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information

Entry name

NDUS2_CAEEL

Primary accession number

Q93873

Secondary accession numbers

None

Integrated into Swiss-Prot on

July 15, 1998

Sequence was last modified on

January 1, 1998 (Sequence version 2)

Annotations were last modified on

September 2, 2008 (Entry version 68)

Name and origin of the protein

Protein name

Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [Precursor]

Synonyms

EC 1.6.5.3
EC 1.6.99.3
NADH-ubiquinone oxidoreductase 49 kDa subunit
Complex I-49kD
CI-49kD

Gene name

	Name:	gas-1
	ORFNames:	K09A9.5

From

Caenorhabditis elegans

[TaxID: 6239]

Taxonomy

Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.

Protein existence

2: Evidence at transcript level;

References

[1]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).

Comments

FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
CATALYTIC ACTIVITY: NADH + ubiquinone = NAD⁺ + ubiquinol.
CATALYTIC ACTIVITY: NADH + acceptor = NAD⁺ + reduced acceptor.
COFACTOR: Binds 1 4Fe-4S cluster (By similarity).
SUBUNIT: Complex I is composed of 45 different subunits. Component of the iron-sulfur (IP) fragment of the enzyme (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity).
SIMILARITY: Belongs to the complex I 49 kDa subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Z79601; CAB01886.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

T23532; T23532.

NP_510569.1; -.

3D structure databases

ModBase

Q93873.

Organism-specific databases

WormBase

WBGene00001520; gas-1.

WormPep

K09A9.5; CE11980. [WormPep / WorfDB]

Gene expression databases

ArrayExpress

Q93873; -.

Ontologies

GO:0040007;	Biological process: growth (inferred from mutant phenotype from WormBase).
GO:0040011;	Biological process: locomotion (inferred from mutant phenotype from WormBase).
GO:0006120;	Biological process: mitochondrial electron transport, NADH to ubiquinone (inferred from mutant phenotype from WormBase).
GO:0002119;	Biological process: nematode larval development (inferred from mutant phenotype from WormBase).
GO:0000003;	Biological process: reproduction (inferred from mutant phenotype from WormBase).
GO:0042493;	Biological process: response to drug (inferred from mutant phenotype from WormBase).
QuickGo view.

Family and domain databases

InterPro

IPR014029; NADH-UbQ_OxRdtase_49kDa_CS.
IPR010219; NADH_DH_1_dsu.
IPR001135; NADH_UbQ_OxRdtase_49kDa.
Graphical view of domain structure.

Pfam

PF00346; Complex1_49kDa; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01962; NuoD; 1.

PROSITE

PS00535; COMPLEX1_49K; 1.

BLOCKS

Q93873.

Genome annotation databases

Ensembl

K09A9.5; Caenorhabditis elegans. [Contig view]

GeneID

181646; -.

KEGG

cel:K09A9.5; -.

Other

ProtoNet

Q93873.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Respiratory chain; Transit peptide; Transport; Ubiquinone.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 ?`		`Mitochondrion (Potential).`
`CHAIN`	`? 482`		`Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial.`	`PRO_0000019983`
`METAL`	`345 345`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`351 351`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`366 366`		`Iron-sulfur (4Fe-4S) (Potential).`

Sequence information

Length: 482 AA [This is the length of the unprocessed precursor]

Molecular weight: 54563 Da [This is the MW of the unprocessed precursor]

CRC64: ACF06535338418B1 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLGRKIAGTC LRANVPSVAA TSSTPATQTR NSHTIWYPDA KFERQFKTGG TLGKLWMSER 

        70         80         90        100        110        120 
VSDFDEKIGL DKLEKLAYSD PVMSDNYSGK QREKNLENMI LNFGPQHPAA HGVLRLVLKL 

       130        140        150        160        170        180 
EGEVIIKAIP HIGLLHRATE KLIEHKTYTQ ALPYFDRLDY VSMMCNEQAW SLAVEKLLGI 

       190        200        210        220        230        240 
DIPTRAKYIR TLMGELTRIQ NHIMGITTHA LDVGAMTPFF WMFEEREKLF EFSERVSGAR 

       250        260        270        280        290        300 
MHANYVRPGG VAWDLPIGLM DDIYDWAIKF PERIDELEDM LTENRIWKAR TIDIGLVSAA 

       310        320        330        340        350        360 
DALNWGFSGV MVRGSGIKQD VRKTEPYDAY ADMEFDVPIG TKGDCYDRYL CRIEEMRQSL 

       370        380        390        400        410        420 
NIVHQCLNKM PAGEIKVDDH KVVPPKRAEM KENMESLIHH FKFFTEGFQV PPGATYVPIE 

       430        440        450        460        470        480 
APKGEFGVYL VADGTGKPYR CFIRAPGFAH LAAIHDVCYM SLIADIVAVI GTMDIVFGEV 


DR

Q93873 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools