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UniProtKB/Swiss-Prot entry Q93714

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH3A_CAEEL
Primary accession number Q93714
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on April 13, 2004 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 61)
Name and origin of the protein
Protein name Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial [Precursor]
Synonyms EC 1.1.1.41
Isocitric dehydrogenase
NAD(+)-specific ICDH
Gene name
ORFNames: F43G9.1
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z79755; CAB02111.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T22149; T22149.
RefSeq NP_492330.2; -.
UniGene Cel.17675
3D structure databases
HSSP P08200; 1PB1. [HSSP ENTRY / PDB]
ModBase Q93714.
Protein-protein interaction databases
IntAct Q93714; -.
Organism-specific databases
WormBase WBGene00009664; F43G9.1.
WormPep F43G9.1; CE34018. [WormPep / WorfDB]
Gene expression databases
ArrayExpress Q93714; -.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0010171; Biological process: body morphogenesis (inferred from mutant phenotype from WormBase).
GO:0009792; Biological process: embryonic development ending in birth or egg hatching (inferred from mutant phenotype from WormBase).
GO:0040035; Biological process: hermaphrodite genitalia development (inferred from mutant phenotype from WormBase).
GO:0040011; Biological process: locomotion (inferred from mutant phenotype from WormBase).
GO:0040010; Biological process: positive regulation of growth rate (inferred from mutant phenotype from WormBase).
QuickGo view.
Family and domain databases
InterPro IPR004434; IsoCit_DHase_NAD_mit.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00175; mito_nad_idh; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q93714.
Genome annotation databases
Ensembl F43G9.1; Caenorhabditis elegans. [Contig view]
GeneID 172655; -.
KEGG cel:F43G9.1; -.
Other
ProtoNet Q93714.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Magnesium; Manganese; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Transit peptide; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   358        Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial. PRO_0000014441
METAL   226   226        Magnesium or manganese (By similarity). 
METAL   250   250        Magnesium or manganese (By similarity). 
METAL   254   254        Magnesium or manganese (By similarity). 
BINDING   108   108        Substrate (By similarity). 
BINDING   118   118        Substrate (By similarity). 
BINDING   139   139        Substrate (By similarity). 
BINDING   226   226        Substrate (By similarity). 
SITE   146   146  1     Critical for catalysis (By similarity). 
SITE   193   193  1     Critical for catalysis (By similarity). 
Sequence information
Length: 358 AA [This is the length of the unprocessed precursor] Molecular weight: 38466 Da [This is the MW of the unprocessed precursor] CRC64: B175DC68C127610F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLGKCIKKAS STVGQSIRYS SGDVRRVTLI PGDGIGPEIS ASVQKIFEAA DAPIAWDPVD 

        70         80         90        100        110        120 
VTPVKGRDGV FRIPSRCIEL MHANKVGLKG PLETPIGKGH RSLNLAVRKE FSLYANVRPC 

       130        140        150        160        170        180 
RSLEGHKTLY DNVDVVTIRE NTEGEYSGIE HEIVPGVVQS IKLITETASR NVASFAFEYA 

       190        200        210        220        230        240 
RQNGRKVVTA VHKANIMRQS DGLFLSICRE QAALYPDIKF KEAYLDTVCL NMVQDPSQYD 

       250        260        270        280        290        300 
VLVMPNLYGD ILSDLCAGLV GGLGVTPSGN IGKGAAVFES VHGTAPDIAG QDKANPTALL 

       310        320        330        340        350 
LSAVMMLRYM NLPQHAARIE KAVFDAIADG RAKTGDLGGT GTCSSFTADV CARVKDLE
Q93714 in FASTA format

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