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UniProtKB/Swiss-Prot entry Q92913


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FGF13_HUMAN
Primary accession number Q92913
Secondary accession number O95830
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on February 1, 1997 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 72)
Name and origin of the protein
Protein name Fibroblast growth factor 13
Synonyms FGF-13
Fibroblast growth factor homologous factor 2
FHF-2
Gene name
Name: FGF13
Synonyms: FHF2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A).
TISSUE=Retina;
DOI=10.1073/pnas.93.18.9850; PubMed=8790420 [NCBI, ExPASy, EBI, Israel, Japan]
Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.;
"Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.";
Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 1B).
TISSUE=Brain;
DOI=10.1007/s004390050910; PubMed=10071193 [NCBI, ExPASy, EBI, Israel, Japan]
Gecz J., Baker E., Donnelly A., Ming J.E., McDonnald-McGinn D.M., Spinner N.B., Zackai E.H., Sutherland G.R., Mulley J.C.;
"Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Borjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient.";
Hum. Genet. 104:56-63(1999).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLN-197.
Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N., Nguyen C.P., Nguyen D.A., Poel C.L., Chambers S.W., Schackwitz W.S., Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.;
"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A).
TISSUE=Lung, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U66198; AAB18914.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF100143; AAD16400.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF100144; AAD16401.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY672645; AAT70720.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC012347; AAH12347.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC034340; AAH34340.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_004105.1; -.
NP_378668.1; -.
UniGene Hs.6540
3D structure databases
HSSP P31371; 1G82. [HSSP ENTRY / PDB]
SMR Q92913; 64-201.
ModBase Q92913.
Polymorphism databases
NIEHS-SNPs FGF13.
Organism-specific databases
H-InvDB HIX0017088; -.
HGNC HGNC:3670; FGF13.
GenAtlas FGF13.
HPA HPA002809; -.
MIM 300070; gene. [NCBI / EBI]
PharmGKB PA28109; -.
GeneCards Q92913.
Gene expression databases
ArrayExpress Q92913; -.
CleanEx HS_FGF13; -.
GermOnline ENSG00000129682; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from physical interaction from MGI).
GO:0005634; Cellular component: nucleus (inferred from direct assay from MGI).
GO:0008083; Molecular function: growth factor activity (traceable author statement from ProtInc).
GO:0030295; Molecular function: protein kinase activator activity (inferred from genetic interaction from MGI).
GO:0007267; Biological process: cell-cell signaling (traceable author statement from ProtInc).
GO:0000165; Biological process: MAPKKK cascade (inferred from direct assay from MGI).
GO:0007399; Biological process: nervous system development (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR002209; GF_heparin_bd.
IPR002348; IL1_HBGF.
Graphical view of domain structure.
PANTHER PTHR11486; IL1_HBGF; 1.
Pfam PF00167; FGF; 1.
Pfam graphical view of domain structure.
PRINTS PR00263; HBGFFGF.
PR00262; IL1HBGF.
ProDom PD000831; IL1_HBGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00442; FGF; 1.
SMART graphical view of domain structure.
PROSITE PS00247; HBGF_FGF; 1.
BLOCKS Q92913.
Genome annotation databases
Ensembl ENSG00000129682; Homo sapiens. [Contig view]
GeneID 2258; -.
KEGG hsa:2258; -.
Phylogenomic databases
HOVERGEN Q92913; -.
Other
SOURCE FGF13; Homo sapiens.
ProtoNet Q92913.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Growth factor; Polymorphism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   245  245     Fibroblast growth factor 13. PRO_0000147607
VAR_SEQ   1    62        MAAAIASSLIRQKRQAREREKSNACKCVSSPSKGKTSCDK NKLNVFSRVKLFGSKKRRRRRP -> MALLRKSYS (in isoform 1B). VSP_001529
VARIANT   197   197  1     K -> Q. VAR_020945 
Sequence information
Length: 245 AA [This is the length of the unprocessed precursor] Molecular weight: 27564 Da [This is the MW of the unprocessed precursor] CRC64: 30FB62C6B2669F29 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAAAIASSLI RQKRQARERE KSNACKCVSS PSKGKTSCDK NKLNVFSRVK LFGSKKRRRR 

        70         80         90        100        110        120 
RPEPQLKGIV TKLYSRQGYH LQLQADGTID GTKDEDSTYT LFNLIPVGLR VVAIQGVQTK 

       130        140        150        160        170        180 
LYLAMNSEGY LYTSELFTPE CKFKESVFEN YYVTYSSMIY RQQQSGRGWY LGLNKEGEIM 

       190        200        210        220        230        240 
KGNHVKKNKP AAHFLPKPLK VAMYKEPSLH DLTEFSRSGS GTPTKSRSVS GVLNGGKSMS 


HNEST 

Q92913 in FASTA format

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