[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). TISSUE=Fetal brain; DOI=10.1038/sj.onc.1200935; PubMed=9121761 [NCBI, ExPASy, EBI, Israel, Japan] Meyerhardt J.A., Look A.T., Bigner S.H., Fearon E.R.; "Identification and characterization of neogenin, a DCC-related gene."; Oncogene 14:1129-1136(1997).
[2]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). TISSUE=Fetal brain; DOI=10.1006/geno.1997.4688; PubMed=9169140 [NCBI, ExPASy, EBI, Israel, Japan] Vielmetter J., Chen X.-N., Miskevich F., Lane R.P., Yamakawa K., Korenberg J.R., Dreyer W.J.; "Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23."; Genomics 41:414-421(1997).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). TISSUE=Brain; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[4]	GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-210 AND ASN-489, AND MASS SPECTROMETRY. TISSUE=Plasma; DOI=10.1021/pr0502065; PubMed=16335952 [NCBI, ExPASy, EBI, Israel, Japan] Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.; "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."; J. Proteome Res. 4:2070-2080(2005).
[5]	STRUCTURE BY NMR OF 429-1054. RIKEN structural genomics initiative (RSGI); "The solution structure of the six fibronectin type III domains of human neogenin."; Submitted (NOV-2005) to the PDB data bank.

Comments

FUNCTION: May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing. Additional isoforms seem to exist.

Name 1

Isoform ID Q92859-1

This is the isoform sequence displayed in this entry.

Name 2

Isoform ID Q92859-2

Features which should be applied to build the isoform sequence: VSP_002593.
TISSUE SPECIFICITY: Widely expressed and also in cancer cell lines.
SIMILARITY: Belongs to the immunoglobulin superfamily. DCC family.
SIMILARITY: Contains 6 fibronectin type-III domains.
SIMILARITY: Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U61262; AAB17263.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U72391; AAC51287.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC117161; AAI17162.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_002490.2; -.

UniGene

Hs.388613

3D structure databases

PDB

1X5F; NMR; -; A=429-535.	[ExPASy / RCSB / EBI]
1X5G; NMR; -; A=529-631.	[ExPASy / RCSB / EBI]
1X5H; NMR; -; A=623-741.	[ExPASy / RCSB / EBI]
1X5I; NMR; -; A=718-831.	[ExPASy / RCSB / EBI]
1X5J; NMR; -; A=853-952.	[ExPASy / RCSB / EBI]
1X5K; NMR; -; A=942-1054.	[ExPASy / RCSB / EBI]

Detailed list of linked structures.

PDBsum

1X5F; -.
1X5G; -.
1X5H; -.
1X5I; -.
1X5J; -.
1X5K; -.

Q92859; 616-744.

PTM databases

Q92859; -.

Organism-specific databases

HIX0038163; -.

HGNC:7754; NEO1.

CAB009320; -.

601907; gene. [NCBI / EBI]

PharmGKB

PA31555; -.

GeneCards

Q92859.

Gene expression databases

ArrayExpress

Q92859; -.

CleanEx

HS_NEO1; -.

GermOnline

ENSG00000067141; Homo sapiens.

Ontologies

GO:0005887;	Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0007155;	Biological process: cell adhesion (non-traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR008957; Fibronectin_typ-III-like_fold.
IPR003961; FN_III.
IPR003962; FnIII_subd.
IPR013151; Ig.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR010560; Neogenin_C.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.30; FN_III-like; 6.
G3DSA:2.60.40.10; Ig-like_fold; 4.

Pfam

PF00041; fn3; 6.
PF07679; I-set; 3.
PF00047; ig; 1.
PF06583; Neogenin_C; 1.
Pfam graphical view of domain structure.

PRINTS

PR00014; FNTYPEIII.

SMART

SM00060; FN3; 6.
SM00409; IG; 1.
SM00408; IGc2; 3.
SMART graphical view of domain structure.

PROSITE

PS50853; FN3; 6.
PS50835; IG_LIKE; 4.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q92859.

Genome annotation databases

Ensembl

ENSG00000067141; Homo sapiens. [Contig view]

GeneID

4756; -.

KEGG

hsa:4756; -.

Phylogenomic databases

HOGENOM

Q92859; -.

HOVERGEN

Q92859; -.

Other

NEO1; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Alternative splicing; Cell adhesion; Cell membrane; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Repeat; Signal; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 33`	`33`	`Potential.`
`CHAIN`	`34 1461`	`1428`	`Neogenin.`	`PRO_0000015043`
`TOPO_DOM`	`34 1105`	`1072`	`Extracellular (Potential).`
`TRANSMEM`	`1106 1126`	`21`	`Potential.`
`TOPO_DOM`	`1127 1461`	`335`	`Cytoplasmic (Potential).`
`DOMAIN`	`52 141`	`90`	`Ig-like C2-type 1.`
`DOMAIN`	`152 238`	`87`	`Ig-like C2-type 2.`
`DOMAIN`	`243 336`	`94`	`Ig-like C2-type 3.`
`DOMAIN`	`341 426`	`86`	`Ig-like C2-type 4.`
`DOMAIN`	`439 532`	`94`	`Fibronectin type-III 1.`
`DOMAIN`	`539 627`	`89`	`Fibronectin type-III 2.`
`DOMAIN`	`633 728`	`96`	`Fibronectin type-III 3.`
`DOMAIN`	`735 827`	`93`	`Fibronectin type-III 4.`
`DOMAIN`	`853 949`	`97`	`Fibronectin type-III 5.`
`DOMAIN`	`954 1051`	`98`	`Fibronectin type-III 6.`
`COMPBIAS`	`1118 1121`	`4`	`Poly-Val.`
`CARBOHYD`	`73 73`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`210 210`		`N-linked (GlcNAc...).`
`CARBOHYD`	`326 326`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`470 470`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`489 489`		`N-linked (GlcNAc...).`
`CARBOHYD`	`639 639`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`715 715`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`909 909`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`74 129`		`By similarity.`
`DISULFID`	`173 221`		`By similarity.`
`DISULFID`	`270 320`		`By similarity.`
`DISULFID`	`362 410`		`By similarity.`
`VAR_SEQ`	`1248 1300`		`Missing (in isoform 2).`	`VSP_002593`
`VARIANT`	`534 534`	`1`	`P -> L (in dbSNP:rs4467039 [NCBI]).`	`VAR_027954`
`CONFLICT`	`168 168`		`N -> G (in Ref. 1; AAB17263).`
`STRAND`	`443 450`	`8`
`STRAND`	`455 460`	`6`
`STRAND`	`470 479`	`10`
`STRAND`	`486 489`	`4`
`STRAND`	`496 500`	`5`
`STRAND`	`508 516`	`9`
`STRAND`	`521 524`	`4`
`STRAND`	`528 531`	`4`
`STRAND`	`546 551`	`6`
`STRAND`	`554 558`	`5`
`STRAND`	`570 578`	`9`
`STRAND`	`587 589`	`3`
`STRAND`	`591 596`	`6`
`STRAND`	`604 612`	`9`
`STRAND`	`638 643`	`6`
`STRAND`	`646 655`	`10`
`TURN`	`659 661`	`3`
`STRAND`	`666 670`	`5`
`STRAND`	`672 675`	`4`
`STRAND`	`678 683`	`6`
`STRAND`	`693 697`	`5`
`STRAND`	`704 708`	`5`
`STRAND`	`710 713`	`4`
`STRAND`	`716 720`	`5`
`STRAND`	`724 727`	`4`
`STRAND`	`743 750`	`8`
`STRAND`	`753 759`	`7`
`STRAND`	`770 775`	`6`
`HELIX`	`780 782`	`3`
`STRAND`	`783 786`	`4`
`STRAND`	`793 796`	`4`
`STRAND`	`808 812`	`5`
`STRAND`	`858 866`	`9`
`STRAND`	`869 875`	`7`
`STRAND`	`881 883`	`3`
`STRAND`	`890 895`	`6`
`STRAND`	`897 902`	`6`
`STRAND`	`912 919`	`8`
`STRAND`	`929 933`	`5`
`STRAND`	`959 965`	`7`
`STRAND`	`973 978`	`6`
`STRAND`	`989 996`	`8`
`STRAND`	`998 1000`	`3`
`TURN`	`1002 1004`	`3`
`STRAND`	`1005 1011`	`7`
`STRAND`	`1015 1019`	`5`
`STRAND`	`1024 1035`	`12`
`STRAND`	`1047 1050`	`4`

Sequence information

Length: 1461 AA [This is the length of the unprocessed precursor]

Molecular weight: 160017 Da [This is the MW of the unprocessed precursor]

CRC64: 4AADF1EEBCAFD82C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAAERGARRL LSTPSFWLYC LLLLGRRAPG AAAARSGSAP QSPGASIRTF TPFYFLVEPV 

        70         80         90        100        110        120 
DTLSVRGSSV ILNCSAYSEP SPKIEWKKDG TFLNLVSDDR RQLLPDGSLF ISNVVHSKHN 

       130        140        150        160        170        180 
KPDEGYYQCV ATVESLGTII SRTAKLIVAG LPRFTSQPEP SSVYAGNNAI LNCEVNADLV 

       190        200        210        220        230        240 
PFVRWEQNRQ PLLLDDRVIK LPSGMLVISN ATEGDGGLYR CVVESGGPPK YSDEVELKVL 

       250        260        270        280        290        300 
PDPEVISDLV FLKQPSPLVR VIGQDVVLPC VASGLPTPTI KWMKNEEALD TESSERLVLL 

       310        320        330        340        350        360 
AGGSLEISDV TEDDAGTYFC IADNGNETIE AQAELTVQAQ PEFLKQPTNI YAHESMDIVF 

       370        380        390        400        410        420 
ECEVTGKPTP TVKWVKNGDM VIPSDYFKIV KEHNLQVLGL VKSDEGFYQC IAENDVGNAQ 

       430        440        450        460        470        480 
AGAQLIILEH APATTGPLPS APRDVVASLV STRFIKLTWR TPASDPHGDN LTYSVFYTKE 

       490        500        510        520        530        540 
GIARERVENT SHPGEMQVTI QNLMPATVYI FRVMAQNKHG SGESSAPLRV ETQPEVQLPG 

       550        560        570        580        590        600 
PAPNLRAYAA SPTSITVTWE TPVSGNGEIQ NYKLYYMEKG TDKEQDVDVS SHSYTINGLK 

       610        620        630        640        650        660 
KYTEYSFRVV AYNKHGPGVS TPDVAVRTLS DVPSAAPQNL SLEVRNSKSI MIHWQPPAPA 

       670        680        690        700        710        720 
TQNGQITGYK IRYRKASRKS DVTETLVSGT QLSQLIEGLD RGTEYNFRVA ALTINGTGPA 

       730        740        750        760        770        780 
TDWLSAETFE SDLDETRVPE VPSSLHVRPL VTSIVVSWTP PENQNIVVRG YAIGYGIGSP 

       790        800        810        820        830        840 
HAQTIKVDYK QRYYTIENLD PSSHYVITLK AFNNVGEGIP LYESAVTRPH TDTSEVDLFV 

       850        860        870        880        890        900 
INAPYTPVPD PTPMMPPVGV QASILSHDTI RITWADNSLP KHQKITDSRY YTVRWKTNIP 

       910        920        930        940        950        960 
ANTKYKNANA TTLSYLVTGL KPNTLYEFSV MVTKGRRSST WSMTAHGTTF ELVPTSPPKD 

       970        980        990       1000       1010       1020 
VTVVSKEGKP KTIIVNWQPP SEANGKITGY IIYYSTDVNA EIHDWVIEPV VGNRLTHQIQ 

      1030       1040       1050       1060       1070       1080 
ELTLDTPYYF KIQARNSKGM GPMSEAVQFR TPKADSSDKM PNDQASGSGG KGSRLPDLGS 

      1090       1100       1110       1120       1130       1140 
DYKPPMSGSN SPHGSPTSPL DSNMLLVIIV SVGVITIVVV VIIAVFCTRR TTSHQKKKRA 

      1150       1160       1170       1180       1190       1200 
ACKSVNGSHK YKGNSKDVKP PDLWIHHERL ELKPIDKSPD PNPIMTDTPI PRNSQDITPV 

      1210       1220       1230       1240       1250       1260 
DNSMDSNIHQ RRNSYRGHES EDSMSTLAGR RGMRPKMMMP FDSQPPQPVI SAHPIHSLDN 

      1270       1280       1290       1300       1310       1320 
PHHHFHSSSL ASPARSHLYH PGSPWPIGTS MSLSDRANST ESVRNTPSTD TMPASSSQTC 

      1330       1340       1350       1360       1370       1380 
CTDHQDPEGA TSSSYLASSQ EEDSGQSLPT AHVRPSHPLK SFAVPAIPPP GPPTYDPALP 

      1390       1400       1410       1420       1430       1440 
STPLLSQQAL NHHIHSVKTA SIGTLGRSRP PMPVVVPSAP EVQETTRMLE DSESSYEPDE 

      1450       1460 
LTKEMAHLEG LMKDLNAITT A

Q92859 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools