[1]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=FVB/N; Vaz F.M., Ofman R., Wanders R.J.A.; "Identification of mouse gamma-butyrobetaine hydroxylase cDNA."; Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Liver; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Catalyzes the formation of L-carnitine from gamma-butyrobetaine (By similarity).
CATALYTIC ACTIVITY: 4-trimethylammoniobutanoate + 2-oxoglutarate + O₂ = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO₂.
COFACTOR: Iron (By similarity).
COFACTOR: Ascorbate (By similarity).
PATHWAY: Amine and polyamine biosynthesis; carnitine biosynthesis .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the gamma-BBH/TMLD family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY033514; AAK54388.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC019406; AAH19406.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_569719.1; -.

UniGene

Mm.27335

3D structure databases

ModBase

Q924Y0.

Organism-specific databases

MGI

MGI:1891372; Bbox1.

Gene expression databases

ArrayExpress

Q924Y0; -.

GermOnline

ENSMUSG00000041660; Mus musculus.

Ontologies

GO:0008336;	Molecular function: gamma-butyrobetaine dioxygenase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0045329;	Biological process: carnitine biosynthetic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR012775; 2-oxoglut_dOase.
IPR003819; Taurine_dOase.
Graphical view of domain structure.

Pfam

PF02668; TauD; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02409; carnitine_bodg; 1.

BLOCKS

Q924Y0.

Genome annotation databases

Ensembl

ENSMUSG00000041660; Mus musculus. [Contig view]

GeneID

170442; -.

KEGG

mmu:170442; -.

Phylogenomic databases

HOGENOM

Q924Y0; -.

HOVERGEN

Q924Y0; -.

Other

Bbox1; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Carnitine biosynthesis; Cytoplasm; Dioxygenase; Iron; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 387`	`387`		`Gamma-butyrobetaine dioxygenase.`	`PRO_0000207086`

Sequence information

Length: 387 AA [This is the length of the unprocessed precursor]

Molecular weight: 44699 Da [This is the MW of the unprocessed precursor]

CRC64: 9F17F5F9CAE052BE [This is a checksum on the sequence]

        10         20         30         40         50         60 
MHCAILKAEA VDGAHLMQIF WHDGAESLYP AVWLRDNCQC SDCYLHSAKA RKLLLEALDV 

        70         80         90        100        110        120 
NIRIDDLTFD RKKVYITWPN DHYSEFEANW LKKRCFSQQA RARLQGELFL PECQYWGSEL 

       130        140        150        160        170        180 
QLPTLNFEDV LNDDDHAYKW LSSLKKVGIV RLTGAADKRG EIIKLGKRIG FLYLTFYGHT 

       190        200        210        220        230        240 
WQVQDKIDAN NVAYTTGKLS FHTDYPALHH PPGVQLLHCI KQTVTGGDSE IVDGFNVCQK 

       250        260        270        280        290        300 
LKEKNPQAFH ILSSTFVDFT DIGVDYCDFS VQSKHKIIEL DDKGQVVRVN FNNATRDTVF 

       310        320        330        340        350        360 
DVPIERVQPF YAALKEFVDL MNSKEYKYTF KMNPGDVITF DNWRLLHGRR SYEAGTEISR 

       370        380 
HLEGAYADWD VVMSRLRILR QRVTNGN

Q924Y0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools