[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Kidney; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

CATALYTIC ACTIVITY: 2 glutathione + H₂O₂ = glutathione disulfide + 2 H₂O.
SUBCELLULAR LOCATION: Secreted (By similarity).
SIMILARITY: Belongs to the glutathione peroxidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC013526; AAH13526.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

UniGene

Mm.46195

3D structure databases

HSSP

P00435; 1GP1. [HSSP ENTRY / PDB]

ModBase

Q91WR8.

Protein family/group databases

PeroxiBase

3719; MmGPx06.

Organism-specific databases

MGI

MGI:1922762; Gpx6.

Gene expression databases

ArrayExpress

Q91WR8; -.

CleanEx

MM_GPX6; -.

GermOnline

ENSMUSG00000004341; Mus musculus.

Family and domain databases

InterPro

IPR000889; Glut_peroxidase.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.30.10; Thioredoxin_fold; 1.

PANTHER

PTHR11592; Glut_peroxidase; 1.

Pfam

PF00255; GSHPx; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000303; Glutathion_perox; 1.

PRINTS

PR01011; GLUTPROXDASE.

PROSITE

PS00460; GLUTATHIONE_PEROXID_1; 1.
PS00763; GLUTATHIONE_PEROXID_2; 1.
PS51355; GLUTATHIONE_PEROXID_3; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q91WR8.

Genome annotation databases

Ensembl

ENSMUSG00000004341; Mus musculus. [Contig view]

Phylogenomic databases

HOGENOM

Q91WR8; -.

HOVERGEN

Q91WR8; -.

Other

Gpx6; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Oxidoreductase; Peroxidase; Secreted; Signal.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 19`	`19`	`Potential.`
`CHAIN`	`20 221`	`202`	`Glutathione peroxidase 6.`	`PRO_0000013082`
`ACT_SITE`	`73 73`		`By similarity.`

Sequence information

Length: 221 AA [This is the length of the unprocessed precursor]

Molecular weight: 24845 Da [This is the MW of the unprocessed precursor]

CRC64: 15308DC6E4BA996A [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAQKLWGSCL FSLFMAALAQ ETLNPQKSKV DCNKGVTGTV YEYGANTIDG GGFVNFQQYA 

        70         80         90        100        110        120 
GKHILFVNVA SFCGLTATYP ELNTLQEELK PFNVTVLGFP CNQFGKQEPG KNSEILLGLK 

       130        140        150        160        170        180 
YVRPGGGYVP NFQLFEKGDV NGDNEQKVFS FLKNSCPPTS ELFGSPEHLF WDPMKIHDIR 

       190        200        210        220 
WNFEKFLVGP DGVPVMRWFH HTPVRIVQSD IMEYLNQTST Q

Q91WR8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools