FUNCTION: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth (By similarity).
CATALYTIC ACTIVITY: Succinate + acceptor = fumarate + reduced acceptor.
COFACTOR: Binds 1 2Fe-2S cluster.
COFACTOR: Binds 1 3Fe-4S cluster.
COFACTOR: Binds 1 4Fe-4S cluster.
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and an hydrophobic anchor protein (By similarity).
SIMILARITY: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
SIMILARITY: Contains 1 2Fe-2S ferredoxin-type domain.
SIMILARITY: Contains 1 4Fe-4S ferredoxin-type domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE008730; AAL19679.1; ALT_INIT; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_459720.1; -.

3D structure databases

HSSP

P07014; 1NEK. [HSSP ENTRY / PDB]

SMR

Q8ZQU2; 1-238.

ModBase

Q8ZQU2.

Enzyme and pathway databases

BioCyc

STYP99287:STM0735-MON; -.

Organism-specific databases

StyGene

SG?????; sdhB.

Ontologies

GO:0000104;	Molecular function: succinate dehydrogenase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR006058; 2Fe2S_fd_BS.
IPR001450; 4Fe4S_Fe_S_bd.
IPR012675; b-grasp_ferredoxin-like.
IPR001041; Ferredoxin.
IPR012285; Fum_reductase_C.
IPR004489; Succ_DHase/fum_Rdtase_Fe-S.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.20.30; Ferredoxin_fold; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.

TIGRFAMs

TIGR00384; dhsB; 1.

PROSITE

PS00197; 2FE2S_FER_1; FALSE_NEG.
PS51085; 2FE2S_FER_2; 1.
PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q8ZQU2.

Genome annotation databases

GeneID

1252255; -.

GenomeReviews

AE006468_GR; STM0735.

KEGG

stm:STM0735; -.

Phylogenomic databases

HOGENOM

Q8ZQU2; -.

Genome annotation databases

CMR

Q8ZQU2; STM0735.

Other

ProtoNet

Q8ZQU2.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

2Fe-2S; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 238`	`238`	`Succinate dehydrogenase iron-sulfur subunit.`	`PRO_0000158692`
`DOMAIN`	`1 97`	`97`	`2Fe-2S ferredoxin-type.`
`DOMAIN`	`139 169`	`31`	`4Fe-4S ferredoxin-type.`
`METAL`	`55 55`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`60 60`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`63 63`		`Iron-sulfur 1 (2Fe-2S) (Potential).`
`METAL`	`75 75`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`149 149`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`152 152`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`155 155`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`159 159`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`206 206`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`212 212`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`216 216`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`

Sequence information

Length: 238 AA [This is the length of the unprocessed precursor]

Molecular weight: 26733 Da [This is the MW of the unprocessed precursor]

CRC64: 7628F9F9F95611F3 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKLEFSIYRY NPDVDNAPRM QDYTLEGEEG RDMMLLDALI QLKEKDPSLS FRRSCREGVC 

        70         80         90        100        110        120 
GSDGLNMNGK NGLACITPIS ALTQPGKKIV IRPLPGLPVI RDLVVDMGQF YAQYEKIKPY 

       130        140        150        160        170        180 
LLNNGQNPPA REHLQMPEQR EKLDGLYECI LCACCSTSCP SFWWNPDKFI GPAGLLAAYR 

       190        200        210        220        230 
FLIDSRDTET DSRLEGMSDA FSVFRCHSIM NCVSVCPKGL NPTRAIGHIK SMLLQRSA

Q8ZQU2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools