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UniProtKB/Swiss-Prot entry Q8YP78

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDH_ANASP
Primary accession number Q8YP78
Secondary accession numbers None
Integrated into Swiss-Prot on August 16, 2004
Sequence was last modified on August 16, 2004 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 39)
Name and origin of the protein
Protein name Malate dehydrogenase
Synonym EC 1.1.1.37
Gene name
Name: mdh
OrderedLocusNames: alr4322
From
Anabaena sp. (strain PCC 7120) [TaxID: 103690] [HAMAP proteome]
Taxonomy Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1093/dnares/8.5.205; PubMed=11759840 [NCBI, ExPASy, EBI, Israel, Japan]
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M., Takazawa M., Yamada M., Yasuda M., Tabata S.;
"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120.";
DNA Res. 8:205-213(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000019; BAB76021.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AC2346; AC2346.
RefSeq NP_488362.1; -.
3D structure databases
HSSP P80039; 1GV0. [HSSP ENTRY / PDB]
ModBase Q8YP78.
Enzyme and pathway databases
BioCyc NSP103690:ALR4322-MON; -.
Ontologies
GO
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00487; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR011275; Malate_DHase_NAD-dep_bac.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01763; MalateDH_bact; 1.
BLOCKS Q8YP78.
ProtoNet Q8YP78.
Genome annotation databases
GeneID 1107924; -.
GenomeReviews BA000019_GR; alr4322.
KEGG ana:alr4322; -.
NMPDR fig|103690.1.peg.4629; -.
Phylogenomic databases
HOGENOM Q8YP78; -.
Genome annotation databases
CMR Q8YP78; alr4322.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   323  323     Malate dehydrogenase. PRO_0000113421
NP_BIND   20    25  6     NAD (By similarity). 
NP_BIND   129   131  3     NAD (By similarity). 
ACT_SITE   186   186        Proton acceptor (By similarity). 
BINDING   44    44        NAD (By similarity). 
BINDING   93    93        Substrate (By similarity). 
BINDING   99    99        Substrate (By similarity). 
BINDING   106   106        NAD (By similarity). 
BINDING   131   131        Substrate (By similarity). 
BINDING   162   162        Substrate (By similarity). 
Sequence information
Length: 323 AA [This is the length of the unprocessed precursor] Molecular weight: 34924 Da [This is the MW of the unprocessed precursor] CRC64: 081EEA3377A457B7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MFSSPDSPIL HCLPRVAIIG AGRVGSTLAQ RIAEKNLADV VLLDIVEGIP QGLALDLLEA 

        70         80         90        100        110        120 
RGIELHNRQI IGTNNYADTS GSQIVVITAG FPRKPGMSRD DLLRTNAKIV IEAAKQAIAY 

       130        140        150        160        170        180 
SPYAIFIVVT NPLDVMTYLA WEATGLPRNR IMGMAGVLDS ARFETFIALE LGVLPADVKA 

       190        200        210        220        230        240 
MVLGSHGDLM VPLSRYATVN GIPITQLLDA VTIERLVERT RNGGAEIVEL MQTGGAFFAP 

       250        260        270        280        290        300 
ASATSLMVES ILLNQSRLLP VSIYLQGEYD LKDVVIGVPC RLGLNGIESV IELNLSDSER 

       310        320 
EALHISAKSV QKNIERWRSL QNS
Q8YP78 in FASTA format

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