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UniProtKB/Swiss-Prot entry Q8YJ78

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PROA_BRUME
Primary accession number Q8YJ78
Secondary accession numbers None
Integrated into Swiss-Prot on June 6, 2002
Sequence was last modified on November 7, 2003 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 46)
Name and origin of the protein
Protein name Gamma-glutamyl phosphate reductase
Synonyms GPR
EC 1.2.1.41
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
GSA dehydrogenase
Gene name
Name: proA
OrderedLocusNames: BMEI0208
From
Brucella melitensis [TaxID: 29459] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=16M / ATCC 23456 / NCTC 10094 / Biotype 1;
DOI=10.1073/pnas.221575398; PubMed=11756688 [NCBI, ExPASy, EBI, Israel, Japan]
DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R.;
"The genome sequence of the facultative intracellular pathogen Brucella melitensis.";
Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE009463; AAL51390.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AC3278; AC3278.
RefSeq NP_539126.1; -.
3D structure databases
HSSP Q9WYC9; 1O20. [HSSP ENTRY / PDB]
ModBase Q8YJ78.
Enzyme and pathway databases
BioCyc BMEL224914:BMEI0208-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004350; Molecular function: glutamate-5-semialdehyde dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006561; Biological process: proline biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00412; -; 1.
PBIL [Tree]
InterPro IPR016163; Ald_DHase_C.
IPR016162; Ald_DHase_N.
IPR000965; Gglut_pp_reduct.
IPR012134; Glu-5-SA_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.
G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11063:SF1; GSA_DH; 1.
PIRSF PIRSF000151; GPR; 1.
TIGRFAMs TIGR00407; proA; 1.
PROSITE PS01223; PROA; 1.
BLOCKS Q8YJ78.
Genome annotation databases
GeneID 1195920; -.
GenomeReviews AE008917_GR; BMEI0208.
KEGG bme:BMEI0208; -.
NMPDR fig|224914.1.peg.208; -.
Phylogenomic databases
HOGENOM Q8YJ78; -.
Genome annotation databases
CMR Q8YJ78; BMEI0208.
Other
ProtoNet Q8YJ78.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   421  421     Gamma-glutamyl phosphate reductase. PRO_0000189706
Sequence information
Length: 421 AA [This is the length of the unprocessed precursor] Molecular weight: 44094 Da [This is the MW of the unprocessed precursor] CRC64: 89798D02ACE81350 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTKDIAQVMA EVGRKAKAAA APLSIATNEQ KNKALNAAAD AILEARADIL EANRLDLANA 

        70         80         90        100        110        120 
EKNGMAASFV DRLTLNEARI DAIAEGIRAI ATLPDPVGEV IAEWDRPNGL HIERVRTPLG 

       130        140        150        160        170        180 
VIGVIYESRP NVTADAGALC LKAGNAVILR GGSDSAHSSA AIYKALVKGL EAANLPADAI 

       190        200        210        220        230        240 
QIVPVTDRAA VGEMLKGLGG AIDVIVPRGG KSLVARVQSE ARVPVFAHLE GICHLYIDKS 

       250        260        270        280        290        300 
ADLDMARRIA LDAKMRRTGI CGAAETLLVD RAVASTHLAP ILGDLAAGGC EIRGSAEVLA 

       310        320        330        340        350        360 
LYPAAKPATE EDWSTEYLDA IISVALVDGI SGAIDHINRY SSHHTEAIVA EDAQTVARFF 

       370        380        390        400        410        420 
NEIDSAILLH NASTQFADGG EFGMGAEIGI ATGKMHARGP VGVEQLTSFK YRVRGSGQVR 


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Q8YJ78 in FASTA format

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