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UniProtKB/Swiss-Prot entry Q8YHB2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TGT_BRUME
Primary accession number Q8YHB2
Secondary accession numbers None
Integrated into Swiss-Prot on May 2, 2002
Sequence was last modified on March 1, 2002 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 40)
Name and origin of the protein
Protein name Queuine tRNA-ribosyltransferase
Synonyms EC 2.4.2.29
tRNA-guanine transglycosylase
Guanine insertion enzyme
Gene name
Name: tgt
OrderedLocusNames: BMEI0890
From
Brucella melitensis [TaxID: 29459] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=16M / ATCC 23456 / NCTC 10094 / Biotype 1;
DOI=10.1073/pnas.221575398; PubMed=11756688 [NCBI, ExPASy, EBI, Israel, Japan]
DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R.;
"The genome sequence of the facultative intracellular pathogen Brucella melitensis.";
Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE009529; AAL52071.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AD3363; AD3363.
RefSeq NP_539807.1; -.
3D structure databases
HSSP P28720; 1K4G. [HSSP ENTRY / PDB]
ModBase Q8YHB2.
Enzyme and pathway databases
BioCyc BMEL224914:BMEI0890-MON; -.
Ontologies
GO
GO:0008479; Molecular function: queuine tRNA-ribosyltransferase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008616; Biological process: queuosine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00168; -; 1.
PBIL [Tree]
InterPro IPR004803; QtRNA_ribo_trans.
IPR002616; tRNA_ribo_trans.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.105; tRNA_ribo_trans; 1.
PANTHER PTHR11962; tRNA_ribo_trans; 1.
Pfam PF01702; TGT; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00430; Q_tRNA_tgt; 1.
TIGR00449; tgt_general; 1.
BLOCKS Q8YHB2.
ProtoNet Q8YHB2.
Genome annotation databases
GeneID 1196601; -.
GenomeReviews AE008917_GR; BMEI0890.
KEGG bme:BMEI0890; -.
NMPDR fig|224914.1.peg.889; -.
Phylogenomic databases
HOGENOM Q8YHB2; -.
Genome annotation databases
CMR Q8YHB2; BMEI0890.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glycosyltransferase; Metal-binding; Queuosine biosynthesis; Transferase; tRNA processing; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   377  377     Queuine tRNA-ribosyltransferase. PRO_0000135455
ACT_SITE   94    94        Nucleophile (By similarity). 
METAL   308   308        Zinc (By similarity). 
BINDING   95    95        Substrate (By similarity). 
Sequence information
Length: 377 AA [This is the length of the unprocessed precursor] Molecular weight: 41466 Da [This is the MW of the unprocessed precursor] CRC64: 9A6AAD13C86E5BD8 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTTENFGFKV LARDGAARQG EISMPRGVVR TPAFMPVGTA GTVKAMYMDQ VKELGADIIL 

        70         80         90        100        110        120 
GNTYHLMLRP GAERVARLGG LHEFGGWKGP ILTDSGGFQV MSLAQLRKLN EHGVTFRSHI 

       130        140        150        160        170        180 
DGKAYEMTPE RSIEIQGLLD SDIQMQLDEC VALPSPEKNT ERAMELSLRW AERCKVAFGD 

       190        200        210        220        230        240 
QPGKAMFGIV QGGDIARLRE RSAEALKAMD LKGYSVGGLA VGEPQEVMLD MLEVVCPILP 

       250        260        270        280        290        300 
TEKPRYLMGV GTPDDILKSV ARGIDMFDCV MPTRAGRHGL AFTRFGKVNL RNARHAEDHR 

       310        320        330        340        350        360 
PLDPQSDCPA SRDYSRAYLH HLVKSGEALG AMLLTWNNLA YYQYLMKGIR AAIADGKFSD 

       370 
FTAETTEGWA RGDMPAL
Q8YHB2 in FASTA format

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