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UniProtKB/Swiss-Prot entry Q8Y6Z6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH2_LISMO
Primary accession number Q8Y6Z6
Secondary accession numbers None
Integrated into Swiss-Prot on June 21, 2004
Sequence was last modified on March 1, 2002 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 40)
Name and origin of the protein
Protein name L-lactate dehydrogenase 2
Synonyms L-LDH 2
EC 1.1.1.27
Gene name
Name: ldh2
OrderedLocusNames: lmo1534
From
Listeria monocytogenes [TaxID: 1639] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Listeriaceae; Listeria.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-679 / EGD-e / Serovar 1/2a;
DOI=10.1126/science.1063447; PubMed=11679669 [NCBI, ExPASy, EBI, Israel, Japan]
Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D., Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W., Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U., Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A., Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
"Comparative genomics of Listeria species.";
Science 294:849-852(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL591979; CAC99612.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AF1266; AF1266.
RefSeq NP_465059.1; -.
3D structure databases
HSSP P00344; 1LDB. [HSSP ENTRY / PDB]
ModBase Q8Y6Z6.
Enzyme and pathway databases
BioCyc LMON169963:LMO1534-MON; -.
Organism-specific databases
ListiList LMO01534; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS Q8Y6Z6.
Genome annotation databases
GeneID 987808; -.
GenomeReviews AL591824_GR; lmo1534.
KEGG lmo:lmo1534; -.
Phylogenomic databases
HOGENOM Q8Y6Z6; -.
Genome annotation databases
CMR Q8Y6Z6; lmo1534.
Other
ProtoNet Q8Y6Z6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   311  311     L-lactate dehydrogenase 2. PRO_0000168366
NP_BIND   12    40  29     NAD (By similarity). 
ACT_SITE   177   177        Proton acceptor (By similarity). 
BINDING   90    90        Substrate (By similarity). 
BINDING   122   122        NAD or substrate (By similarity). 
BINDING   153   153        Substrate (By similarity). 
BINDING   230   230        Substrate (By similarity). 
Sequence information
Length: 311 AA [This is the length of the unprocessed precursor] Molecular weight: 33741 Da [This is the MW of the unprocessed precursor] CRC64: D7DB065307C8E301 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKPRKVMIIG AGNVGTAAAH AFVNQKFVEE LILVDLNKER VEGNRKDLAD AAAFMPGKMD 

        70         80         90        100        110        120 
ITVRDASDCA DVDIAVITVT AGPLKEGQTR LDELRSTSRI VSGIVPEMMK GGFNGIFLIA 

       130        140        150        160        170        180 
TNPCDIITYQ VWKLSGLPRE RVLGTGVWLD TTRLRRLLAE KLDIAAQSID AFILGEHGDS 

       190        200        210        220        230        240 
QFPVWSHSSI YGKPVNEYSL EKLGESLDLK QIGETARDTG FEIYHQKGCT EYGIGGTIVE 

       250        260        270        280        290        300 
ICRHIFSGSQ RALTVSCVLD GEYGESGLAI GVPAVLSQNG VKEIISLKLD EQEQQAFANS 

       310 
VSVIKKSIAS I
Q8Y6Z6 in FASTA format

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