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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], POST-TRANSLATIONAL MODIFICATIONS, AND MASS SPECTROMETRY.
STRAIN=168 / RO-A-4, 168 / RO-PP-2, W23 / DV3-D-2, and W23 / RO-E-2;
PubMed=12067344 [NCBI, ExPASy, EBI, Israel, Japan]
Ansaldi M.,
Marolt D.,
Stebe T.,
Mandic-Mulec I.,
Dubnau D.;
"Specific activation of the Bacillus quorum-sensing systems by isoprenylated pheromone variants.";
Mol. Microbiol. 44:1561-1573(2002).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=W23 / DV3-D-2;
Sabotic J.,
Cepon U.,
Cadez P.,
Mandic Mulec I.;
"Variability of Bacillus sp. quorum sensing system.";
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
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[3]
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ISOPRENYLATION AT TRP-56.
DOI=10.1038/nchembio709; PubMed=16407988 [NCBI, ExPASy, EBI, Israel, Japan]
Okada M.,
Sato I.,
Cho S.J.,
Iwata H.,
Nishio T.,
Dubnau D.,
Sakagami Y.;
"Structure of the Bacillus subtilis quorum-sensing peptide pheromone ComX.";
Nat. Chem. Biol. 1:23-24(2005).
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[4]
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POLYMORPHISM IN COMX; COMQ AND COMP.
DOI=10.1128/JB.183.2.451-460.2001; PubMed=11133937 [NCBI, ExPASy, EBI, Israel, Japan]
Tortosa P.,
Logsdon L.,
Kraigher B.,
Itoh Y.,
Mandic-Mulec I.,
Dubnau D.;
"Specificity and genetic polymorphism of the Bacillus competence quorum-sensing system.";
J. Bacteriol. 183:451-460(2001).
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[5]
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POLYMORPHISM, AND DETERMINANTS OF MODIFICATION SPECIFICITY.
DOI=10.1128/JB.186.1.15-21.2004; PubMed=14679219 [NCBI, ExPASy, EBI, Israel, Japan]
Ansaldi M.,
Dubnau D.;
"Diversifying selection at the Bacillus quorum-sensing locus and determinants of modification specificity during synthesis of the ComX pheromone.";
J. Bacteriol. 186:15-21(2004).
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- FUNCTION: Part of a major quorum-sensing system that regulates the development of genetic competence. Acts through the activation of the two-component regulatory system comP/comA composed of a sensor histidine kinase, comP, and a response regulator, comA, that regulates directly the transcription of over 20 genes. Transport through the membrane may involve spo0K. Under certain conditions plays a role in sporulation.
- SUBCELLULAR LOCATION: Secreted.
- PTM: Isoprenylation of Trp-56 is essential for activity. The type of isoprenyl derivative differs among the different pherotypes and depends on comX primary sequence. ComQ is required for the production of comX and may be responsible alone for its complete maturation.
- MISCELLANEOUS: The DNA sequences encoding comQ, comX and the N-terminal two-thirds of comP show a striking polymorphism, which determines the specificity of the quorum-sensing system in the different pherotypes of Bacillus. In comX, the sole conserved residue is the modified tryptophan essential for the activity.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 58 AA [This is the length of the unprocessed precursor] |
Molecular weight: 6684 Da [This is the MW of the unprocessed precursor] |
CRC64: BC6095F268EC1EFE [This is a checksum on the sequence] |
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10 20 30 40 50
MKQDMIDYLM KNPQVLTKLE NGEASLIGIP DKLIPSIVDI FNKKMTLSKK CKGIFWEQ
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Q8VL79 in FASTA format |
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