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UniProtKB/Swiss-Prot entry Q8UHX1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_AGRT5
Primary accession number Q8UHX1
Secondary accession numbers None
Integrated into Swiss-Prot on March 25, 2003
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 44)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: Atu0537
ORFNames: AGR_C_948
From
Agrobacterium tumefaciens (strain C58 / ATCC 33970) [TaxID: 176299] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1066804; PubMed=11743193 [NCBI, ExPASy, EBI, Israel, Japan]
Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P., Clendenning J., Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., Nester E.W.;
"The genome of the natural genetic engineer Agrobacterium tumefaciens C58.";
Science 294:2317-2323(2001).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1066803; PubMed=11743194 [NCBI, ExPASy, EBI, Israel, Japan]
Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C., Allinger M., Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S.;
"Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58.";
Science 294:2323-2328(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE007869; AAK86351.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR AE2642; AE2642.
F97424; F97424.
RefSeq NP_353566.1; -.
3D structure databases
HSSP P06988; 1KAE. [HSSP ENTRY / PDB]
ModBase Q8UHX1.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q8UHX1.
Genome annotation databases
GeneID 1132575; -.
GenomeReviews AE007869_GR; Atu0537.
KEGG atc:AGR_C_948; -.
atu:Atu0537; -.
Phylogenomic databases
HOGENOM Q8UHX1; -.
Genome annotation databases
CMR Q8UHX1; Atu0537.
Other
ProtoNet Q8UHX1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   432  432     Histidinol dehydrogenase. PRO_0000135714
ACT_SITE   327   327        Proton acceptor (By similarity). 
ACT_SITE   328   328        Proton acceptor (By similarity). 
METAL   259   259        Zinc (By similarity). 
METAL   262   262        Zinc (By similarity). 
METAL   361   361        Zinc (By similarity). 
METAL   420   420        Zinc (By similarity). 
BINDING   130   130        NAD (By similarity). 
BINDING   191   191        NAD (By similarity). 
BINDING   214   214        NAD (By similarity). 
BINDING   237   237        Substrate (By similarity). 
BINDING   259   259        Substrate (By similarity). 
BINDING   262   262        Substrate (By similarity). 
BINDING   328   328        Substrate (By similarity). 
BINDING   361   361        Substrate (By similarity). 
BINDING   415   415        Substrate (By similarity). 
BINDING   420   420        Substrate (By similarity). 
Sequence information
Length: 432 AA [This is the length of the unprocessed precursor] Molecular weight: 45806 Da [This is the MW of the unprocessed precursor] CRC64: B1A794B64953518F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAIWLERASA DFEQKFAAFL TTKREVSEDV NATVRDIIND VRHRGDAALA HYSQKFDGID 

        70         80         90        100        110        120 
FTRVSMRVTA DEIDAAFSAV DRAVIEALEL AARRIEKHHA RQMPKDDIYE DDIGVGLGSR 

       130        140        150        160        170        180 
WTAIEAVGLY VPGGTASYPS SVLMNAVPAK VAGVERIVMV VPANGGAVNP AVLAAARIAG 

       190        200        210        220        230        240 
VEEIYRIGGA QAVAALAYGT ETIAPVAKIV GPGNAYVAAA KRQVFGTVGI DMIAGPSEVL 

       250        260        270        280        290        300 
VIADKDNDPD WLAADLLAQA EHDRGAQSIL ITDNADLGKA VGAAVERQLK LLSRSETAAA 

       310        320        330        340        350        360 
SWADFGAIIL VEKLTDAIPL ANRIAAEHLE LAVDDPDALM AHIRNAGAIF VGRHTPEVIG 

       370        380        390        400        410        420 
DYVGGSNHVL PTARSARFSS GLSVLDFVKR TSILRLGPEQ LRQLAPAAIT LAHSEGLDAH 

       430 
ARSVSIRLNP ES
Q8UHX1 in FASTA format

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