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UniProtKB/Swiss-Prot entry Q8THW2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACDA3_METAC
Primary accession number Q8THW2
Secondary accession numbers None
Integrated into Swiss-Prot on November 21, 2003
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 44)
Name and origin of the protein
Protein name Acetyl-CoA decarbonylase/synthase complex subunit alpha 3
Synonyms ACDS complex subunit alpha 3
EC 1.2.99.2
ACDS complex carbon monoxide dehydrogenase 3
ACDS CODH 3
Gene name
Name: cdhA3
OrderedLocusNames: MA_4399
From
Methanosarcina acetivorans [TaxID: 2214] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
DOI=10.1101/gr.223902; PubMed=11932238 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P., McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.;
"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity.";
Genome Res. 12:532-542(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE010299; AAM07741.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_619261.1; -.
3D structure databases
HSSP P00193; 1DUR. [HSSP ENTRY / PDB]
ModBase Q8THW2.
Enzyme and pathway databases
BioCyc MACE188937:MA4399-MON; -.
Ontologies
GO
GO:0018492; Molecular function: carbon-monoxide dehydrogenase (acceptor) activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01137; -; 1.
PBIL [Tree]
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR004460; CO_DHase/Ac-CoA_synth_asu.
IPR016101; CO_DHase_a-bundle.
IPR004137; Prismane.
IPR016099; Prismane-like_a/b-sand.
Graphical view of domain structure.
Gene3D G3DSA:1.20.1270.30; CO_DH_a-bundle; 1.
G3DSA:3.40.50.2030; Prismane-like_a/b-sand; 2.
Pfam PF00037; Fer4; 2.
PF03063; Prismane; 1.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
TIGRFAMs TIGR00314; cdhA; 1.
PROSITE PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 2.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q8THW2.
Genome annotation databases
GeneID 1476293; -.
GenomeReviews AE010299_GR; MA_4399.
KEGG mac:MA4399; -.
NMPDR fig|188937.1.peg.4287; -.
Phylogenomic databases
HOGENOM Q8THW2; -.
Genome annotation databases
CMR Q8THW2; MA_4399.
Other
ProtoNet Q8THW2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding; Methanogenesis; Nickel; Oxidoreductase; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   805  805     Acetyl-CoA decarbonylase/synthase complex subunit alpha 3. PRO_0000155076
DOMAIN   407   435  29     4Fe-4S ferredoxin-type 1. 
DOMAIN   445   474  30     4Fe-4S ferredoxin-type 2. 
METAL   72    72        Iron-sulfur 1 (4Fe-4S); shared with dimeric partner (By similarity). 
METAL   75    75        Iron-sulfur 1 (4Fe-4S); shared with dimeric partner (By similarity). 
METAL   76    76        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   78    78        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   83    83        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   93    93        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   249   249        Nickel-iron-sulfur (By similarity). 
METAL   277   277        Nickel-iron-sulfur (By similarity). 
METAL   322   322        Nickel-iron-sulfur (By similarity). 
METAL   416   416        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   419   419        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   422   422        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   426   426        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   454   454        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   457   457        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   460   460        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   464   464        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   522   522        Nickel-iron-sulfur (By similarity). 
METAL   551   551        Nickel-iron-sulfur (By similarity). 
METAL   586   586        Nickel-iron-sulfur (By similarity). 
Sequence information
Length: 805 AA [This is the length of the unprocessed precursor] Molecular weight: 87993 Da [This is the MW of the unprocessed precursor] CRC64: 8B1B9B32B56C56CD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSKLTTGSFS IEDLESVQIT INNIVGAAKE AAEEKAKELG PMGPTAMAGL ASYRSWNLLL 

        70         80         90        100        110        120 
LDRYEPVLTP MCDQCCYCTY GPCDLSGNKR GACGIDMAGQ TGREFFLRVI TGTACHAAHG 

       130        140        150        160        170        180 
RHLLDHVIEV FGEDLPLNLG ESNVLTPNVT ICTGLSPKTL GECRAPMEYV EEQLTQLLAT 

       190        200        210        220        230        240 
IHAGQESAEI DYDSKALFSG SLDHVGMEVS DIAQVSAYDF PKADPEAPLI EIGMGSIDKS 

       250        260        270        280        290        300 
KPLIVAIGHN VAGVTYIMDY MEENNLTDKM EIAGLCCTAF DMTRYKEADR RAPYAKIVGS 

       310        320        330        340        350        360 
LAKELKVIRS GMPDVIVVDE QCVRGDVLSE SMKLKIPVIA SNEKIMMGLP DRTDADVDSI 

       370        380        390        400        410        420 
VEEIKSGAIP GCVMLDYDKL GELIPKIAEV MAPIRDAEGI TAIPTDEEFK VYIDKCVKCG 

       430        440        450        460        470        480 
ECMLACPEEL DIPEALEYAA KGSYEYLEAL HDVCIGCRRC EQVCKKEIPI LNVLEKAAQK 

       490        500        510        520        530        540 
SISEEKGWVR SGRGQASDAE IRAEGLNLVM GTTPGIIAII GCPNYPAGTK DVYNIAEEFL 

       550        560        570        580        590        600 
KRNYLVVVSG CSAMDIGMYK DDDGKTLYER YPGTFSGGGL LNTGSCVSNA HITGAAEKVA 

       610        620        630        640        650        660 
GIFAQRTLAG NLAEVADYTL NRVGACGLAW GAYSQKAASI GTGCNIYGIP AVLGPHSSKY 

       670        680        690        700        710        720 
RRALIAKTYE EDKWKVFDAR DGSEMNIPPA PEFLLTTAET WQEALPMMAK ACIRPSDNNM 

       730        740        750        760        770        780 
GRSIKLTHWM ELSKKYLGVE PEDWWKFVRN EADLPLAKRE ELLKRLEAEQ GWEIDWKRKK 

       790        800 
IISGPKIKFD VSAQPTNLKR LCKEA
Q8THW2 in FASTA format

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