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[1]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
DOI=10.1101/gr.223902; PubMed=11932238 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E.,
Nusbaum C.,
Roy A.,
Endrizzi M.G.,
Macdonald P.,
FitzHugh W.,
Calvo S.,
Engels R.,
Smirnov S.,
Atnoor D.,
Brown A.,
Allen N.,
Naylor J.,
Stange-Thomann N.,
DeArellano K.,
Johnson R.,
Linton L.,
McEwan P.,
McKernan K., ![]()
Talamas J.,
Tirrell A.,
Ye W.,
Zimmer A.,
Barber R.D.,
Cann I.,
Graham D.E.,
Grahame D.A.,
Guss A.M.,
Hedderich R.,
Ingram-Smith C.,
Kuettner H.C.,
Krzycki J.A.,
Leigh J.A.,
Li W.,
Liu J.,
Mukhopadhyay B.,
Reeve J.N.,
Smith K.,
Springer T.A.,
Umayam L.A.,
White O.,
White R.H.,
de Macario E.C.,
Ferry J.G.,
Jarrell K.F.,
Jing H.,
Macario A.J.L.,
Paulsen I.T.,
Pritchett M.,
Sowers K.R.,
Swanson R.V.,
Zinder S.H.,
Lander E.,
Metcalf W.W.,
Birren B.;
"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity.";
Genome Res. 12:532-542(2002).
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- FUNCTION: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
- CATALYTIC ACTIVITY: Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.
- SUBUNIT: Heterodimer of a large subunit and a small subunit (By similarity).
- SIMILARITY: Belongs to the archaeal DNA polymerase II family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 1145 AA [This is the length of the unprocessed precursor] |
Molecular weight: 127679 Da [This is the MW of the unprocessed precursor] |
CRC64: 36C329A400C09E43 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MGETIASEEM HEYFDGLEAR LKEAIEIANR ARAQGGDPKP TVEIPLAKDL ADRVENLIGV
70 80 90 100 110 120
QGVAAKIREL ETRMSREEAA LEIGKQVAEG VVGSFPTKKD AVEAAIRVSM ATLTEGVVAA
130 140 150 160 170 180
PIEGIDKVEL GKNDDGSQYI RIFYSGPIRS AGGTAQALSV LVGDYVRRGI GIDRYKPREE
190 200 210 220 230 240
EVERYVEEIL LYKRVASLQY TPSEDEIRLI VRNCPVCIDG DPTEEAEVEG HRDLERIGTN
250 260 270 280 290 300
RVRGGMCLVL AEGLALKAPK VKKHVNKLKM DGWDWLETLI GGAKSGGSAE DEQKSKIKPK
310 320 330 340 350 360
DKYIRDLIAG RPVFSHPSRP GGFRLRYGRS RNTSFASAGI NPASMVLLDD FITNGTQLKV
370 380 390 400 410 420
ERPGKAAAMS AVDSIEGPTV RLFSGDLVRI DNIKEAYELR PQVESIVDIG EILINYGDFL
430 440 450 460 470 480
ENNHPLMPSP YVFEWWQYDY EAACPEKTPE EELKNPSSAL ALRLAEEYNV PLHPTFTYLW
490 500 510 520 530 540
HDINRNEFEA LRKFVVEKGT FDGEGTLKLP LTASFEEGIK PLLEKLLVLH RVKEDKILVE
550 560 570 580 590 600
EALPFVLCLG LDSSLKEKAG MPDTDDMVEA AGVLSGFKVY PRAPSRIGAR MGRPEKSDLR
610 620 630 640 650 660
KMSPAAQVLF PINNCGGITR NLVSASDYTS CMNGKIGEIE VELGLRECPA CGKETYFWRC
670 680 690 700 710 720
ECGEFTNPKL SCPRCKIDVR GAETCPKCGR KPTSVANVKL DFRSVYKQAF ENVGEREKMD
730 740 750 760 770 780
LIKGVKRLMN GQMTPEPLEK GILRAKHDVY IFKDGTVRYD MSDIPLTHIR ADELGITATK
790 800 810 820 830 840
LLELGYREDI YGNPLERDDQ VVCLKVQDLV ISYDGGEYML RTAKYVDDLL VKYYKVGPYY
850 860 870 880 890 900
NAETIQDLVG VLLIGLAPHT SAGVLGRLIG FTKASVGYAH PFFHASKRRN CDGDEDCIML
910 920 930 940 950 960
LMDGILNFSR SYLPDKRGGK MDAPLVLTTR IDPKEVDKEA HNIDVPARYP LEFYRATQEI
970 980 990 1000 1010 1020
KNPTELESIM DLISGRLGTP EQYEHFMFTH DTSDIAAGPL NSSYKTLGSM IEKMEAQLSL
1030 1040 1050 1060 1070 1080
ANRIRAVDAP DVAERVLKSH FLPDLIGNLR SFSRQRMRCI KCGEKFRRPP LTGACPKCGG
1090 1100 1110 1120 1130 1140
NVVLTVHEGA VRKYLEISKE IGERYGVSSY TRQRIELLDY DICSLFENHK VKQLGLSDFM
SGSAR
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Q8THG5 in FASTA format |
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