[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Liver; PubMed=11717182 [NCBI, ExPASy, EBI, Israel, Japan] Cashman J.R., Zhang J., Leushner J., Braun A.; "Population distribution of human flavin-containing monooxygenase form 3: gene polymorphisms."; Drug Metab. Dispos. 29:1629-1637(2001).

Comments

FUNCTION: Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Acts on TMA to produce TMA-N-oxide.
CATALYTIC ACTIVITY: N,N-dimethylaniline + NADPH + O₂ = N,N-dimethylaniline N-oxide + NADP⁺ + H₂O.
COFACTOR: FAD (By similarity).
SUBCELLULAR LOCATION: Microsome membrane. Endoplasmic reticulum membrane (By similarity).
TISSUE SPECIFICITY: Liver.
SIMILARITY: Belongs to the FMO family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY063498; AAL86612.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001028065.1; -.

UniGene

Mmu.3639

3D structure databases

ModBase

Q8SPQ7.

Family and domain databases

InterPro

IPR012143; dManiline_mOase.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR000960; Flavin_mOase.
IPR002255; Flavin_mOase_3.
Graphical view of domain structure.

Pfam

PF00743; FMO-like; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000332; FMO; 1.

PRINTS

PR00368; FADPNR.
PR00370; FMOXYGENASE.
PR01123; FMOXYGENASE3.

ProDom

PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]

BLOCKS

Q8SPQ7.

Genome annotation databases

Ensembl

ENSMMUG00000007952; Macaca mulatta. [Contig view]

GeneID

574244; -.

KEGG

mcc:574244; -.

Phylogenomic databases

HOVERGEN

Q8SPQ7; -.

Other

ProtoNet

Q8SPQ7.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Endoplasmic reticulum; FAD; Flavoprotein; Membrane; Microsome; Monooxygenase; NADP; Oxidoreductase; Transmembrane.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 532`	`531`	`Dimethylaniline monooxygenase [N-oxide-forming] 3.`	`PRO_0000147655`
`NP_BIND`	`9 14`	`6`	`FAD (Potential).`
`NP_BIND`	`191 196`	`6`	`NADP (Potential).`

Sequence information

Length: 532 AA [This is the length of the unprocessed precursor]

Molecular weight: 60152 Da [This is the MW of the unprocessed precursor]

CRC64: 73A4D13EE2A24A72 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGKKVAIIGA GVSGLASIRS CLEEGLEPTC FEKSNDIGGL WKFSDHAEEG RASIYKSVFT 

        70         80         90        100        110        120 
NSSKEMMCFP DFPYPDDFPN FMHNSKIQEY LTAFAKEKSL LKYIQFKTFV SSVNKRPDFA 

       130        140        150        160        170        180 
TTGQWDVTTE RDGKRESAVF DAVMVCSGHH VYPNLPKESF PGLNHFKGKC FHSRDYKEPG 

       190        200        210        220        230        240 
VFKGKRVLVV GLGNSGCDIA TELSHTAEQV VISSRSGSWV MSRVWDNGYP WDMVLITRFG 

       250        260        270        280        290        300 
TFLKNNLPTA ISDWLYMKQM NARFKHENYG LMPLNGVLRK EPVFNDELPA CILCGIVSVK 

       310        320        330        340        350        360 
PNVKKFTETS AIFEDGTTFE GIDCVIFATG YSYTYTFLDE SIIKNRNNEI ILFKGVFPPL 

       370        380        390        400        410        420 
LEKSTIAVIG FVQSLGAAIP TVDLQSRWAA RVIKGTCTLP SMEDMMNDIN EKMERKHKWY 

       430        440        450        460        470        480 
GKSETLQTDY IVYMDELSSF IGVKPNIPWL FLTDPKLAME VYFGPCSPYQ FRLVGPGKWP 

       490        500        510        520        530 
GARNAILTQW DRSLKPLQTR VVGRLQKPCF FFHWLKPFAI PILLIAVFLG LT

Q8SPQ7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools