ID   GPX1_PIG                Reviewed;         206 AA.
AC   Q8MJ14;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   25-NOV-2008, entry version 41.
DE   RecName: Full=Glutathione peroxidase 1;
DE            EC=1.11.1.9;
DE   AltName: Full=GSHPx-1;
DE            Short=GPx-1;
DE   AltName: Full=Cellular glutathione peroxidase;
GN   Name=GPX1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hostetler C.E., Robison M.R., Kincaid R.L., Ott T.L.;
RT   "Sus scrofa selenium-containing enzyme cytosolic glutathione
RT   peroxidase 1 (cGPX1) from the day 13 embryo.";
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protects the hemoglobin in erythrocytes from oxidative
CC       breakdown (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2 glutathione + H(2)O(2) = glutathione
CC       disulfide + 2 H(2)O.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
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DR   EMBL; AF532927; AAM94630.1; -; mRNA.
DR   RefSeq; NP_999366.1; -.
DR   UniGene; Ssc.6352; -.
DR   SMR; Q8MJ14; 17-200.
DR   PeroxiBase; 3722; SscGPx01.
DR   GeneID; 397403; -.
DR   KEGG; ssc:397403; -.
DR   HOVERGEN; Q8MJ14; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:InterPro.
DR   GO; GO:0008430; F:selenium binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   InterPro; IPR000889; Glut_peroxidase.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   PANTHER; PTHR11592; Glut_peroxidase; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Oxidoreductase; Peroxidase; Selenium;
KW   Selenocysteine.
FT   CHAIN         1    206       Glutathione peroxidase 1.
FT                                /FTId=PRO_0000066614.
FT   ACT_SITE     52     52       By similarity.
FT   NON_STD      52     52       Selenocysteine.
FT   MOD_RES     151    151       N6-acetyllysine (By similarity).
SQ   SEQUENCE   206 AA;  22591 MW;  4431BECD35A797A0 CRC64;
     MCAAQRSAAA LAAVAPRSVY AFSARPLAGG EPISLGSLRG KVLLIENVAS LUGTTVRDYT
     QMNELQRRLG PRGLVVLGFP CNQFGHQENA KNGEILNCLK YVRPGGGFEP NFMLFEKCEV
     NGANAHPLFA FLREALPTPS DDATALMTDP KFITWSPVCR NDIAWNFEKF LVGPDGVPLR
     RYSRRFLTID IEPDIEALLS QEPSSA
//