[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1006/bbrc.1997.7224; PubMed=9299437 [NCBI, ExPASy, EBI, Israel, Japan] Mishina Y., Tizard R., Deng J.M., Pathak B.G., Copeland N.G., Jenkins N.A., Cate R.L., Behringer R.R.; "Sequence, genomic organization, and chromosomal location of the mouse Muellerian-inhibiting substance type II receptor gene."; Biochem. Biophys. Res. Commun. 237:741-746(1997).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
COFACTOR: Magnesium or manganese (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF503863; AAM28608.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC119571; AAI19572.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

JC5629; JC5629.

NP_653130.1; -.

3D structure databases

HSSP

P36897; 1IAS. [HSSP ENTRY / PDB]

ModBase

Q8K592.

Organism-specific databases

MGI

MGI:105062; Amhr2.

Gene expression databases

ArrayExpress

Q8K592; -.

CleanEx

MM_AMHR2; -.

GermOnline

ENSMUSG00000023047; Mus musculus.

Ontologies

GO:0005887;	Cellular component: integral to plasma membrane (traceable author statement from MGI).
GO:0042562;	Molecular function: hormone binding (inferred from sequence or structural similarity from UniProtKB).
GO:0005024;	Molecular function: transforming growth factor beta receptor activity (traceable author statement from MGI).
GO:0007548;	Biological process: sex differentiation (inferred from mutant phenotype from MGI).
GO:0007179;	Biological process: transforming growth factor beta receptor signaling pathway (traceable author statement from MGI).
QuickGo view.

Family and domain databases

InterPro

IPR017193; Anti-muellerian_hrmn_rcpt_II.
IPR015771; Anti-muellerian_hrmn_rcpt_II_C.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.

PANTHER

PTHR23255:SF4; MIS_II_R; 1.

Pfam

PF00069; Pkinase; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF037392; AMHRII; 1.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q8K592.

Genome annotation databases

Ensembl

ENSMUSG00000023047; Mus musculus. [Contig view]

GeneID

110542; -.

KEGG

mmu:110542; -.

NMPDR

fig|10090.3.peg.30707; -.

Phylogenomic databases

HOVERGEN

Q8K592; -.

Other

Amhr2; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 15`	`15`	`Potential.`
`CHAIN`	`16 568`	`553`	`Anti-Muellerian hormone type-2 receptor.`	`PRO_0000260265`
`TOPO_DOM`	`16 147`	`132`	`Extracellular (Potential).`
`TRANSMEM`	`148 168`	`21`	`Potential.`
`TOPO_DOM`	`169 568`	`400`	`Cytoplasmic (Potential).`
`DOMAIN`	`199 504`	`306`	`Protein kinase.`
`NP_BIND`	`205 213`	`9`	`ATP (By similarity).`
`ACT_SITE`	`329 329`		`Proton acceptor (By similarity).`
`BINDING`	`226 226`		`ATP (By similarity).`
`CARBOHYD`	`66 66`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`119 119`		`N-linked (GlcNAc...) (Potential).`
`CONFLICT`	`240 240`		`R -> G (in Ref. 1; AAM28608).`

Sequence information

Length: 568 AA [This is the length of the unprocessed precursor]

Molecular weight: 61195 Da [This is the MW of the unprocessed precursor]

CRC64: AE89AA1727600E5E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EMVDAGPGPP KGIRCLYSHC 

        70         80         90        100        110        120 
CFGIWNLTHG RAQVEMQGCR DSDEPGCESL HCDPVPRAHP NPSSTLFTCS CGTDFCNANY 

       130        140        150        160        170        180 
SHLPPSGNQG APGPQEPQAT PGGPVWMALL LLGMFLVLLL SSIILALLQR KACRVQGGSD 

       190        200        210        220        230        240 
PEPGSGGDCS EELPELAELR FSQVIQEGGH AVVWAGRLQG EMVAIKAFPP RAVAQFRAER 

       250        260        270        280        290        300 
AVYQLLGLQH DHIVRFITAG QGGPGPLPSG PLLVLELYPK GSLCHYLTQY TSDWGSSLRM 

       310        320        330        340        350        360 
ALSLAEGLAF LHEERWQDGQ YKPGIAHRDL SSQNVLIRED RSCAIGDLGL ALVLPGLAQP 

       370        380        390        400        410        420 
PALAPTQPRG PAAILEAGTQ RYMAPELLDK TLDLQDWGTA LQRADVYSLA LLLWEILSRC 

       430        440        450        460        470        480 
SDLRPDHRPP PFQLAYEAEL GSNPSACELW ALAVEERKRP NIPSTWSCSA TDPRGLRELL 

       490        500        510        520        530        540 
EDCWDADPEA RLTAECVQQR LAALAYPHGA SSFPESPQGC PENCLSAPAS AVFPCRPQQS 

       550        560 
SCLLSVQQGP GSRSPDPVGD TVQVYVNE

Q8K592 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools