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UniProtKB/Swiss-Prot entry Q8IY63


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AMOL1_HUMAN
Primary accession number Q8IY63
Secondary accession numbers Q63HK7 Q8NDN0 Q8WXD1 Q96CM5
Integrated into Swiss-Prot on September 27, 2005
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 39)
Name and origin of the protein
Protein name Angiomotin-like protein 1
Synonyms None
Gene name
Name: AMOTL1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Skeletal muscle, and Testis;
The German cDNA consortium;
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Muscle, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-557 (ISOFORM 1).
TISSUE=Brain;
DOI=10.1016/S0378-1119(02)00928-9; PubMed=12406577 [NCBI, ExPASy, EBI, Israel, Japan]
Bratt A., Wilson W.J., Troyanovsky B., Aase K., Kessler R., Van Meir E.G., Holmgren L.;
"Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains.";
Gene 298:69-77(2002).
[4]
ERRATUM.
Bratt A., Wilson W.J., Troyanovsky B., Aase K., Kessler R., Van Meir E.G., Holmgren L.;
Gene 310:231-231(2003).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-51; SER-52 AND SER-61, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1021/pr070152u; PubMed=17924679 [NCBI, ExPASy, EBI, Israel, Japan]
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
J. Proteome Res. 6:4150-4162(2007).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-803 AND SER-805, AND MASS SPECTROMETRY.
DOI=10.1021/pr0705441; PubMed=18220336 [NCBI, ExPASy, EBI, Israel, Japan]
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL833833; CAD38693.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX648729; CAH56180.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC014126; AAH14126.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC037539; AAH37539.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF453742; AAL49764.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_570899.1; -.
UniGene Hs.503594
3D structure databases
HSSP P25054; 1DEB. [HSSP ENTRY / PDB]
ModBase Q8IY63.
Protein-protein interaction databases
IntAct Q8IY63; -.
PTM databases
PhosphoSite Q8IY63; -.
Organism-specific databases
H-InvDB HIX0010033; -.
HGNC HGNC:17811; AMOTL1.
GenAtlas AMOTL1.
HPA HPA001196; -.
PharmGKB PA24774; -.
GeneCards Q8IY63.
Gene expression databases
ArrayExpress Q8IY63; -.
CleanEx HS_AMOTL1; -.
GermOnline ENSG00000166025; Homo sapiens.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR009114; Angiomotin.
Graphical view of domain structure.
PANTHER PTHR14826; Angiomotin; 1.
PRINTS PR01807; ANGIOMOTIN.
BLOCKS Q8IY63.
Genome annotation databases
Ensembl ENSG00000166025; Homo sapiens. [Contig view]
GeneID 154810; -.
KEGG hsa:154810; -.
Phylogenomic databases
HOGENOM Q8IY63; -.
HOVERGEN Q8IY63; -.
Other
ProtoNet Q8IY63.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Coiled coil; Phosphoprotein; Polymorphism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   956  956     Angiomotin-like protein 1. PRO_0000190670
COILED   259   279  21     Potential. 
COILED   438   639  202     Potential. 
COILED   665   694  30     Potential. 
COILED   729   762  34     Potential. 
MOTIF   953   956  4     PDZ-binding. 
MOD_RES   51    51        Phosphothreonine. 
MOD_RES   52    52        Phosphoserine. 
MOD_RES   61    61        Phosphoserine. 
MOD_RES   803   803        Phosphothreonine. 
MOD_RES   805   805        Phosphoserine. 
VAR_SEQ   17    66        Missing (in isoform 2). VSP_015710
VARIANT   847   847  1     P -> L (in dbSNP:rs11020968 [NCBI]). VAR_033498 
CONFLICT   459   460        LQ -> HE (in Ref. 2; AAH14126). 
CONFLICT   649   649        K -> E (in Ref. 1; CAH56180). 
Sequence information
Length: 956 AA [This is the length of the unprocessed precursor] Molecular weight: 106574 Da [This is the MW of the unprocessed precursor] CRC64: 6F47AE3A13816E95 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MWRAKLRRGT CEPAVKGSPS ACYSPSSPVQ VLEDSTYFSP DFQLYSGRHE TSALTVEATS 

        70         80         90        100        110        120 
SIREKVVEDP LCNFHSPNFL RISEVEMRGS EDAAAGTVLQ RLIQEQLRYG TPTENMNLLA 

       130        140        150        160        170        180 
IQHQATGSAG PAHPTNNFSS TENLTQEDPQ MVYQSARQEP QGQEHQVDNT VMEKQVRSTQ 

       190        200        210        220        230        240 
PQQNNEELPT YEEAKAQSQF FRGQQQQQQQ QGAVGHGYYM AGGTSQKSRT EGRPTVNRAN 

       250        260        270        280        290        300 
SGQAHKDEAL KELKQGHVRS LSERIMQLSL ERNGAKQHLP GSGNGKGFKV GGGPSPAQPA 

       310        320        330        340        350        360 
GKVLDPRGPP PEYPFKTKQM MSPVSKTQEH GLFYGDQHPG MLHEMVKPYP APQPVRTDVA 

       370        380        390        400        410        420 
VLRYQPPPEY GVTSRPCQLP FPSTMQQHSP MSSQTSSASG PLHSVSLPLP LPMALGAPQP 

       430        440        450        460        470        480 
PPAASPSQQL GPDAFAIVER AQQMVEILTE ENRVLHQELQ GYYDNADKLH KFEKELQRIS 

       490        500        510        520        530        540 
EAYESLVKST TKRESLDKAM RNKLEGEIRR LHDFNRDLRD RLETANRQLS SREYEGHEDK 

       550        560        570        580        590        600 
AAEGHYASQN KEFLKEKEKL EMELAAVRTA SEDHRRHIEI LDQALSNAQA RVIKLEEELR 

       610        620        630        640        650        660 
EKQAYVEKVE KLQQALTQLQ SACEKREQME RRLRTWLERE LDALRTQQKH GNGQPANMPE 

       670        680        690        700        710        720 
YNAPALLELV REKEERILAL EADMTKWEQK YLEESTIRHF AMNAAATAAA ERDTTIINHS 

       730        740        750        760        770        780 
RNGSYGESSL EAHIWQEEEE VVQANRRCQD MEYTIKNLHA KIIEKDAMIK VLQQRSRKDA 

       790        800        810        820        830        840 
GKTDSSSLRP ARSVPSIAAA TGTHSRQTSL TSSQLAEEKK EEKTWKGSIG LLLGKEHHEH 

       850        860        870        880        890        900 
ASAPLLPPPP TSALSSIAST TAASSAHAKT GSKDSSTQTD KSAELFWPSM ASLPSRGRLS 

       910        920        930        940        950 
TTPAHSPVLK HPAAKGTAEK LENSPGHGKS PDHRGRVSSL LHKPEFPDGE MMEVLI 

Q8IY63 in FASTA format

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