NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
DOI=10.1101/gr.1285603; PubMed=12840036 [NCBI, ExPASy, EBI, Israel, Japan]
Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.;
"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens.";
Genome Res. 13:1572-1579(2003).

Comments

FUNCTION: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide + H₂O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H₂O = L-methionine (S)-S-oxide + thioredoxin.
SIMILARITY: Belongs to the msrA Met sulfoxide reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000035; BAC19574.1; ALT_INIT; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_739374.1; -.

3D structure databases

HSSP

P54149; 1FVG. [HSSP ENTRY / PDB]

ModBase

Q8FLU6.

Enzyme and pathway databases

BioCyc

CEFF196164:CE2764-MON; -.

Ontologies

GO:0008113;	Molecular function: peptide-methionine-(S)-S-oxide reductase activity (inferred from electronic annotation from HAMAP).
GO:0006464;	Biological process: protein modification process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01401; -; 1.
PBIL [Tree]

InterPro

IPR002569; MsrA.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.1060.10; MsrA; 1.

Pfam

PF01625; PMSR; 1.
Pfam graphical view of domain structure.

ProDom

PD003489; PMSR; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR00401; msrA; 1.

BLOCKS

Q8FLU6.

Genome annotation databases

1032113; -.

BA000035_GR; CE2764.

cef:CE2764; -.

fig|196164.1.peg.2764; -.

Phylogenomic databases

HOGENOM

Q8FLU6; -.

Genome annotation databases

CMR

Q8FLU6; CE2764.

Other

ProtoNet

Q8FLU6.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 217`	`217`	`Peptide methionine sulfoxide reductase msrA.`	`PRO_0000138542`
`ACT_SITE`	`56 56`		`By similarity.`

Sequence information

Length: 217 AA [This is the length of the unprocessed precursor]

Molecular weight: 24191 Da [This is the MW of the unprocessed precursor]

CRC64: 0E642BD96745EFD2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAFFFRPEPK MVTPEEALKG GRHPVLESPQ PHTVLGTPIT GPWKEGQKRV WIGLGCFWGV 

        70         80         90        100        110        120 
EQMYWKMDGV ESTSVGYAGG YTPNPTYREV CSGRTGHTEI VEVVYDPEKI TLAELVARGL 

       130        140        150        160        170        180 
EAHDPTQGYR QGNDVGTQYR SAFYVETGEE AETVRQIVST YGETLKSHGF GEITTEVDVI 

       190        200        210 
TPADYYLAED YHQQYLHKNP DGYCPHHSTG IPCGVEA

Q8FLU6 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools