[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=CMCP6; Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.; "Complete genome sequence of Vibrio vulnificus CMCP6."; Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity).
CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde + reduced acceptor.
COFACTOR: FAD (By similarity).
PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1 .
SIMILARITY: Belongs to the GMC oxidoreductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE016796; AAO08544.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_763554.1; -.

3D structure databases

ModBase

Q8D3K2.

Enzyme and pathway databases

BioCyc

VVUL216895:VV2_1688-MON; -.

Ontologies

GO:0008812;	Molecular function: choline dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019285;	Biological process: glycine betaine biosynthetic process from choline (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00750; -; 1.
PBIL [Tree]

InterPro

IPR011533; Choline_dehydrogenase.
IPR012132; GMC_OxRdtase.
IPR000172; GMC_OxRdtase_N.
IPR007867; GMC_OxRtase_C.
Graphical view of domain structure.

Pfam

PF05199; GMC_oxred_C; 1.
PF00732; GMC_oxred_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000137; Alcohol_oxidase; 1.

TIGRFAMs

TIGR01810; betA; 1.

PROSITE

PS00623; GMC_OXRED_1; 1.
PS00624; GMC_OXRED_2; FALSE_NEG.

BLOCKS

Q8D3K2.

Genome annotation databases

GeneID

1181606; -.

GenomeReviews

AE016796_GR; VV2_1688.

KEGG

vvu:VV2_1688; -.

Phylogenomic databases

HOGENOM

Q8D3K2; -.

Genome annotation databases

CMR

Q8D3K2; VV2_1688.

Other

ProtoNet

Q8D3K2.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; FAD; Flavoprotein; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 560`	`560`	`Choline dehydrogenase.`	`PRO_0000205606`
`NP_BIND`	`6 35`	`30`	`FAD (Probable).`
`ACT_SITE`	`470 470`		`By similarity.`

Sequence information

Length: 560 AA [This is the length of the unprocessed precursor]

Molecular weight: 62277 Da [This is the MW of the unprocessed precursor]

CRC64: CD7AA79E8B358748 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MQQHYDYIIV GAGSAGCVLA DRLSESGDHS VLLLEAGGSD KSIFIQMPTA LSYPMNSEKY 

        70         80         90        100        110        120 
AWQFETDAEA DLDGRRLHCP RGKVLGGSSS INGMVYVRGH ACDFDEWEEQ GAKGWNYQAC 

       130        140        150        160        170        180 
LPYFRRAENW IDGEDEYRGG DGPLSTCAGN KMTLNPLYRA FIDAGKEAGY PETSDYNGYQ 

       190        200        210        220        230        240 
QEGFGPMHMT VKNGVRASTS NAYLSRAKKR SNFKLIKGVV VQRILLEEKR AVGVEFELAG 

       250        260        270        280        290        300 
ELRTCFAKNE VISSAGSIGS VQLLQLSGIG PKTVLEKAGV TPVHHLPGVG QNLQDHLEVY 

       310        320        330        340        350        360 
FQYHCQKPIT LNGKLDWFSK GLIGAEWILT RKGLGATNHF ESCAFIRSRA GLKWPNIQYH 

       370        380        390        400        410        420 
FLPAAMRYDG QAAFDGHGFQ VHVGPNKPES RGRVEIVSAN PSDKPKIQFN YLSTERDRQD 

       430        440        450        460        470        480 
WRDCIRLTRE ILAQPAMDEF RGEEIQPGIN VATDAEIDQW VKENVESAYH PSCSCKMGAD 

       490        500        510        520        530        540 
DDPMAVLDEE CRVRGITNLR VVDSSVFPTI PNGNLNAPTI MVAERAADLI LHKQPLPPQR 

       550        560 
SKVWLAPSWE TQQRTGEPMR

Q8D3K2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools