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UniProtKB/Swiss-Prot entry Q8CHT0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AL4A1_MOUSE
Primary accession number Q8CHT0
Secondary accession numbers Q7TND0 Q8BXM3 Q8R0N1 Q8R1S2
Integrated into Swiss-Prot on February 1, 2005
Sequence was last modified on March 1, 2004 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 54)
Name and origin of the protein
Protein name Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [Precursor]
Synonyms P5C dehydrogenase
EC 1.5.1.12
Aldehyde dehydrogenase family 4 member A1
Gene name
Name: Aldh4a1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Retina;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Kidney, and Liver;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-98; LYS-113 AND LYS-401, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1016/j.molcel.2006.06.026; PubMed=16916647 [NCBI, ExPASy, EBI, Israel, Japan]
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.";
Mol. Cell 23:607-618(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK044712; BAC32045.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC024133; AAH24133.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC026589; AAH26589.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC039281; AAH39281.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC056226; AAH56226.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_780647.2; -.
UniGene Mm.273571
3D structure databases
ModBase Q8CHT0.
PTM databases
PhosphoSite Q8CHT0; -.
Organism-specific databases
MGI MGI:2443883; Aldh4a1.
Gene expression databases
ArrayExpress Q8CHT0; -.
CleanEx MM_ALDH4A1; -.
GermOnline ENSMUSG00000028737; Mus musculus.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR005931; d-1-pyrroline-5-COlate_DHase-1.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01236; D1pyr5carbox1; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS Q8CHT0.
Genome annotation databases
Ensembl ENSMUSG00000028737; Mus musculus. [Contig view]
GeneID 212647; -.
KEGG mmu:212647; -.
Phylogenomic databases
HOGENOM Q8CHT0; -.
HOVERGEN Q8CHT0; -.
Other
SOURCE Aldh4a1; Mus musculus.
ProtoNet Q8CHT0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Mitochondrion; NAD; Oxidoreductase; Phosphoprotein; Proline metabolism; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    23  23     Mitochondrion (By similarity). 
CHAIN   24   562  539     Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial. PRO_0000007174
NP_BIND   295   300  6     NAD (By similarity). 
ACT_SITE   313   313        By similarity. 
ACT_SITE   347   347        By similarity. 
MOD_RES   98    98        N6-acetyllysine. 
MOD_RES   113   113        N6-acetyllysine. 
MOD_RES   401   401        N6-acetyllysine. 
MOD_RES   504   504        Phosphotyrosine (By similarity). 
CONFLICT   47    47        D -> G (in Ref. 1; BAC32045). 
Sequence information
Length: 562 AA [This is the length of the unprocessed precursor] Molecular weight: 61811 Da [This is the MW of the unprocessed precursor] CRC64: 0AFBF3FAA0C9C367 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLPLPSLRRS LLSHAWRSAG LRWKHTSSLK VANEPILAFS QGSPERDALQ KALKDLKGQT 

        70         80         90        100        110        120 
EAIPCVVGDE EVWTSDIQYQ LSPFNHAHKV AKFCYADKAL LNRAIDAALA ARKEWDLKPM 

       130        140        150        160        170        180 
ADRAQVFLKA ADMLSGPRRA EVLAKTMVGQ GKTVIQAEID AAAELIDFFR FNAKFAVELE 

       190        200        210        220        230        240 
GEQPISVPPS TNHTVYRGLE GFVAAISPFN FTAIGGNLAG APALMGNVVL WKPSDTAMLA 

       250        260        270        280        290        300 
SYAVYRILRE AGLPPNIIQF VPADGPTFGD TVTSSEHLCG INFTGSVPTF KHLWRQVAQN 

       310        320        330        340        350        360 
LDRFRTFPRL AGECGGKNFH FVHSSADVDS VVSGTLRSAF EYGGQKCSAC SRLYVPKSLW 

       370        380        390        400        410        420 
PQIKGRLLEE HSRIKVGDPA EDFGTFFSAV IDAKAFARIK KWLEHARSSP SLSILAGGQC 

       430        440        450        460        470        480 
NESVGYYVEP CIIESKDPQE PIMKEEIFGP VLTVYVYPDD KYRETLKLVD STTSYGLTGA 

       490        500        510        520        530        540 
VFAQDKAIVQ EATRMLRNAA GNFYINDKST GSVVGQQPFG GARASGTNDK PGGPHYILRW 

       550        560 
TSPQVIKETH KPLGDWRYSY MQ 

Q8CHT0 in FASTA format

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