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UniProtKB/Swiss-Prot entry Q8CGV2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TPH2_MOUSE
Primary accession number Q8CGV2
Secondary accession numbers None
Integrated into Swiss-Prot on May 9, 2003
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 43)
Name and origin of the protein
Protein name Tryptophan 5-hydroxylase 2
Synonyms EC 1.14.16.4
Tryptophan 5-monooxygenase 2
Neuronal tryptophan hydroxylase
Gene name
Name: Tph2
Synonyms: Ntph
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1126/science.1078197; PubMed=12511643 [NCBI, ExPASy, EBI, Israel, Japan]
Walther D.J., Peter J.-U., Bashammakh S., Hortnagl H., Voits M., Fink H., Bader M.;
"Synthesis of serotonin by a second tryptophan hydroxylase isoform.";
Science 299:76-76(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY090565; AAM08923.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Mm.31597
3D structure databases
HSSP P04177; 1TOH. [HSSP ENTRY / PDB]
SMR Q8CGV2; 149-437.
ModBase Q8CGV2.
PTM databases
PhosphoSite Q8CGV2; -.
Organism-specific databases
MGI MGI:2651811; Tph2.
Gene expression databases
ArrayExpress Q8CGV2; -.
CleanEx MM_TPH2; -.
GermOnline ENSMUSG00000006764; Mus musculus.
Ontologies
GO
GO:0004510; Molecular function: tryptophan 5-monooxygenase activity (inferred from direct assay from MGI).
GO:0006587; Biological process: serotonin biosynthetic process from tryptophan (inferred by curator from MGI).
QuickGo view.
Family and domain databases
InterPro IPR001273; Aaa_hydroxylase.
IPR002912; ACT_bd.
IPR005963; Tyr_5_mOase.
Graphical view of domain structure.
Gene3D G3DSA:1.10.800.10; Aaa_hydroxylase; 1.
PANTHER PTHR11473; Aaa_hydroxylase; 1.
Pfam PF01842; ACT; 1.
PF00351; Biopterin_H; 1.
Pfam graphical view of domain structure.
PRINTS PR00372; FYWHYDRXLASE.
ProDom PD002559; Aaa_hydroxylase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01270; Trp_5_monoox; 1.
PROSITE PS00367; BIOPTERIN_HYDROXYL; 1.
BLOCKS Q8CGV2.
Genome annotation databases
Ensembl ENSMUSG00000006764; Mus musculus. [Contig view]
Phylogenomic databases
HOGENOM Q8CGV2; -.
HOVERGEN Q8CGV2; -.
Other
SOURCE Tph2; Mus musculus.
ProtoNet Q8CGV2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Iron; Metal-binding; Monooxygenase; Oxidoreductase; Phosphoprotein; Serotonin biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   488  488     Tryptophan 5-hydroxylase 2. PRO_0000205575
DOMAIN   62   134  73     ACT. 
METAL   316   316        Iron (By similarity). 
METAL   321   321        Iron (By similarity). 
METAL   361   361        Iron (By similarity). 
MOD_RES   380   380        Phosphoserine (By similarity). 
MOD_RES   390   390        Phosphoserine (By similarity). 
Sequence information
Length: 488 AA [This is the length of the unprocessed precursor] Molecular weight: 55918 Da [This is the MW of the unprocessed precursor] CRC64: 8769FB4DAEE80E4A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MQPAMMMFSS KYWARRGLSL DSAVPEDHQL LGSLTQNKAI KSEDKKSGKE PGKGDTTESS 

        70         80         90        100        110        120 
KTAVVFSLKN EVGGLVKALR LFQEKHVNML HIESRRSRRR SSEVEIFVDC ECGKTEFNEL 

       130        140        150        160        170        180 
IQLLKFQTTI VTLNPPESIW TEEEDLEDVP WFPRKISELD RCSHRVLMYG TELDADHPGF 

       190        200        210        220        230        240 
KDNVYRQRRK YFVDVAMGYK YGQPIPRVEY TEEETKTWGV VFRELSKLYP THACREYLKN 

       250        260        270        280        290        300 
LPLLTKYCGY REDNVPQLED VSMFLKERSG FTVRPVAGYL SPRDFLAGLA YRVFHCTQYV 

       310        320        330        340        350        360 
RHGSDPLYTP EPDTCHELLG HVPLLADPKF AQFSQEIGLA SLGASDEDVQ KLATCYFFTI 

       370        380        390        400        410        420 
EFGLCKQEGQ LRAYGAGLLS SIGELKHALS DKACVKSFDP KTTCLQECLI TTFQDAYFVS 

       430        440        450        460        470        480 
DSFEEAKEKM RDFAKSITRP FSVYFNRYTQ SIEILKDTRS IENVVQDLRS DLNTVCDALN 


KMNQYLGI
Q8CGV2 in FASTA format

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