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UniProtKB/Swiss-Prot entry Q8CG70


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name P3H3_MOUSE
Primary accession number Q8CG70
Secondary accession number O88836
Integrated into Swiss-Prot on June 27, 2006
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 41)
Name and origin of the protein
Protein name Prolyl 3-hydroxylase 3 [Precursor]
Synonyms EC 1.14.11.7
Leprecan-like protein 2
Protein B
Gene name
Name: Leprel2
Synonyms: P3h3
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J;
DOI=10.1016/j.bbrc.2004.03.060; PubMed=15063763 [NCBI, ExPASy, EBI, Israel, Japan]
Jaernum S., Kjellman C., Darabi A., Nilsson I., Edvardsen K., Aaman P.;
"LEPREL1, a novel ER and Golgi resident member of the Leprecan family.";
Biochem. Biophys. Res. Commun. 317:342-351(2004).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1074/jbc.M312807200; PubMed=15044469 [NCBI, ExPASy, EBI, Israel, Japan]
Vranka J.A., Sakai L.Y., Bachinger H.P.;
"Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes.";
J. Biol. Chem. 279:23615-23621(2004).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 139-732.
STRAIN=FVB/N;
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 165-732.
PubMed=9445485 [NCBI, ExPASy, EBI, Israel, Japan]
Ansari-Lari M.A., Oeltjen J.C., Schwartz S., Zhang Z., Muzny D.M., Lu J., Gorrell J.H., Chinault A.C., Belmont J.W., Miller W., Gibbs R.A.;
"Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6.";
Genome Res. 8:29-40(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ441086; CAD29580.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY463530; AAS45239.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC003726; AAH03726.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC016431; AAH16431.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC002397; AAC36012.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_038562.2; -.
UniGene Mm.35708
3D structure databases
ModBase Q8CG70.
Organism-specific databases
MGI MGI:1315208; Leprel2.
Gene expression databases
ArrayExpress Q8CG70; -.
CleanEx MM_LEPREL2; -.
GermOnline ENSMUSG00000023191; Mus musculus.
Family and domain databases
InterPro IPR005123; 2OG-FeII_Oase.
IPR000886; ER_targeting_sequence.
IPR006620; Pro_4_hyd_alph.
IPR013026; TPR_region.
Graphical view of domain structure.
Pfam PF03171; 2OG-FeII_Oxy; 1.
Pfam graphical view of domain structure.
SMART SM00702; P4Hc; 1.
SMART graphical view of domain structure.
PROSITE PS00014; ER_TARGET; 1.
PS50005; TPR; FALSE_NEG.
PS50293; TPR_REGION; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q8CG70.
Genome annotation databases
Ensembl ENSMUSG00000023191; Mus musculus. [Contig view]
GeneID 14789; -.
KEGG mmu:14789; -.
Phylogenomic databases
HOVERGEN Q8CG70; -.
Other
SOURCE Leprel2; Mus musculus.
ProtoNet Q8CG70.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Coiled coil; Dioxygenase; Endoplasmic reticulum; Glycoprotein; Iron; Metal-binding; Oxidoreductase; Repeat; Signal; TPR repeat; Vitamin C.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    19  19     Potential. 
CHAIN   20   732  713     Prolyl 3-hydroxylase 3. PRO_0000240361
REPEAT   39    72  34     TPR 1. 
REPEAT   152   185  34     TPR 2. 
REPEAT   214   247  34     TPR 3. 
REPEAT   312   345  34     TPR 4. 
DOMAIN   460   670  211     PKHD. 
COILED   674   703  30     Potential. 
MOTIF   729   732  4     Prevents secretion from ER (Potential). 
COMPBIAS   14    39  26     Pro-rich. 
COMPBIAS   689   697  9     Poly-Glu. 
ACT_SITE   662   662        By similarity. 
METAL   580   580        Iron. 
METAL   582   582        Iron. 
METAL   652   652        Iron. 
CARBOHYD   327   327        N-linked (GlcNAc...) (Potential). 
CARBOHYD   458   458        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 732 AA [This is the length of the unprocessed precursor] Molecular weight: 81701 Da [This is the MW of the unprocessed precursor] CRC64: BD54733B60F1687A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLRLLRLLLL LLLPPPGSPE PPEPPGLAQL SPGSPPQAPD LLYADGLRAY SAGAWAPAVA 

        70         80         90        100        110        120 
LLREALRSRA ALGRARQECG ASCAAEPGAA LPSQLLGAPH PVSGPGVWEP LLLRATLRRA 

       130        140        150        160        170        180 
ECLTQCAVRR LGPGGAARLR VGSALRDAFR RREPYNYLQR AYYQLKKLDL AASAAHTFFV 

       190        200        210        220        230        240 
ANPTHLQMRE DMAKYRRMSA IRPQSFRDLV TPLYWAAYDT GLELLEQREA ALALPQLEEA 

       250        260        270        280        290        300 
LQGSLAHMES CRAACEGPEE HQGAEEEGEG SQGGLYEAIA GHWIRVLQCR QHCVADTATR 

       310        320        330        340        350        360 
PGRSFPVQDF LLSQLRRLHE AYAQVGNMSQ AMENVLSVLL FYPEDEAAKK ALNQYQTQLG 

       370        380        390        400        410        420 
EPRPDLGPRE DIQRFILRSL GEKRQLYYAM EHLGTSFKDP DSWTPEALIP KALRERLRED 

       430        440        450        460        470        480 
QEKKPWDHQP PQQKPLAHWK DALLMEGVTL TQDAQQLNGS ERAVLDGLLT SAECGVLLQL 

       490        500        510        520        530        540 
AKDAAQAGAR SGYRGRRSPH SPHERFEGLT VLKAAQLARA GTVGRPGAKL LLEVSERVRT 

       550        560        570        580        590        600 
LTQAYFSPER PLHLSFTHLV CRSAIEGEQE QRMDLSHPVH ADNCVLDPDT GECWREPPAY 

       610        620        630        640        650        660 
TYRDYSGLLY LNDDFKGGDL FFTQPNALTV TAQVRPRCGR LVAFSSGGEN PHGVWAVTRG 

       670        680        690        700        710        720 
RRCALALWHT WAPEHSEQEW TEAKELLQEE EEEEEEEDIL SRDPSPEPPS HKLQRVQEKA 

       730 
GKPRRVRVRE EL 

Q8CG70 in FASTA format

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