[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Embryo; NIH - Xenopus Gene Collection (XGC) project; Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation (By similarity).
CATALYTIC ACTIVITY: Estradiol-17-beta + NAD(P)⁺ = estrone + NAD(P)H.
PATHWAY: Steroid biosynthesis; estrogen biosynthesis .
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC041194; AAH41194.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001080055.1; -.

UniGene

Xl.21849

3D structure databases

ModBase

Q8AVY8.

Ontologies

GO:0005789;	Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.

Family and domain databases

InterPro

IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.

Pfam

PF00106; adh_short; 1.
Pfam graphical view of domain structure.

PRINTS

PR00081; GDHRDH.
PR00080; SDRFAMILY.

PROSITE

PS00061; ADH_SHORT; 1.

BLOCKS

Q8AVY8.

Genome annotation databases

GeneID

379747; -.

KEGG

xla:379747; -.

Phylogenomic databases

HOVERGEN

Q8AVY8; -.

Other

ProtoNet

Q8AVY8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Endoplasmic reticulum; Lipid synthesis; Membrane; NADP; Oxidoreductase; Steroid biosynthesis; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 318`	`318`	`Estradiol 17-beta-dehydrogenase 12-B.`	`PRO_0000248374`
`TRANSMEM`	`15 35`	`21`	`Potential.`
`TRANSMEM`	`187 207`	`21`	`Potential.`
`TRANSMEM`	`281 301`	`21`	`Potential.`
`NP_BIND`	`54 83`	`30`	`NADP (By similarity).`
`ACT_SITE`	`207 207`		`Proton acceptor (By similarity).`
`BINDING`	`194 194`		`Substrate (By similarity).`

Sequence information

Length: 318 AA [This is the length of the unprocessed precursor]

Molecular weight: 34861 Da [This is the MW of the unprocessed precursor]

CRC64: A5D8971F8AE72AD0 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAPESLAEVP GCNCFWYLGV VAATWWGLRA AWCLLNGARV WVLGSGAQVG PTIGKWAVVT 

        70         80         90        100        110        120 
GATDGIGKAY AEELARRGMN IVLISRSPEK LEEAAIHIKQ KFKVETKIIA ADFGKPTEIY 

       130        140        150        160        170        180 
ERIEAGLRDL EIGVLVNNVG ISYEYPEYFL EIPDLENTLD KMININIMSV CQMTRLVLPG 

       190        200        210        220        230        240 
MLGRGKGVVL NISSASGMYP VPLLTVYSAT KAFVDFFSRG LHAEYRSKGV TVQSVLPFFV 

       250        260        270        280        290        300 
ATKLAKIRKP TWDKPSPETY VRSALNTVGL QTQTNGYLPH AITGWISTSL VPVSAAISMG 

       310 
MKMNKGLRAR FLKKAKQN

Q8AVY8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools