NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=USDA 110;
DOI=10.1093/dnares/9.6.189; PubMed=12597275 [NCBI, ExPASy, EBI, Israel, Japan]
Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110.";
DNA Res. 9:189-197(2002).

Comments

FUNCTION: Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ (By similarity).
CATALYTIC ACTIVITY: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate + 3 O₂ = 4,5-dioxo-3a,4,5,6,7,8,9,9b-octahydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H₂O₂ + 2 H₂O.
PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis .
SIMILARITY: Belongs to the pqqC family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000040; BAC52002.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_773377.1; -.

3D structure databases

ModBase

Q89FG3.

Enzyme and pathway databases

BioCyc

BJAP224911:BLR6737-MON; -.

Ontologies

GO:0033732;	Molecular function: pyrroloquinoline-quinone synthase activity (inferred from electronic annotation from EC).
GO:0018189;	Biological process: pyrroloquinoline quinone biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00654; -; 1.
PBIL [Tree]

InterPro

IPR016084; Haem_Oase-like_multi-hlx.
IPR011845; PQQ_synth_PqqC.
IPR004305; TENA/THI4/PQQ_synth_PqqC.
Graphical view of domain structure.

Gene3D

G3DSA:1.20.910.10; Haem_Oase-like_multi-hlx; 1.

Pfam

PF03070; TENA_THI-4; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02111; PQQ_syn_pqqC; 1.

BLOCKS

Q89FG3.

Genome annotation databases

GeneID

1049991; -.

GenomeReviews

BA000040_GR; blr6737.

KEGG

bja:blr6737; -.

NMPDR

fig|224911.1.peg.6737; -.

Phylogenomic databases

HOGENOM

Q89FG3; -.

Genome annotation databases

CMR

Q89FG3; blr6737.

Other

ProtoNet

Q89FG3.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Oxidoreductase; PQQ biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 259`	`259`		`Pyrroloquinoline-quinone synthase.`	`PRO_0000219977`

Sequence information

Length: 259 AA [This is the length of the unprocessed precursor]

Molecular weight: 29290 Da [This is the MW of the unprocessed precursor]

CRC64: 4D394C1ED932C30E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNAASLTGIT ALSIGKDIKL NSAEELEAAL RHIGATRYHS LHPFHKLLHG GKLNKGQVQA 

        70         80         90        100        110        120 
WALNRYYYQS TIPIKDAVVI SRFRDRATRL EWRHRIEDHD GDVGSEGGIE RWLKLTEGLG 

       130        140        150        160        170        180 
LDTAYVESTE GILPATRFAV EAYVHYCREK SPLEAIASSL TELFAPSIHE ERIAGMLQHY 

       190        200        210        220        230        240 
DFVNPDIMSY FKRRLTQAPR DANFALEYVR THARTPEERA SVCNALIFKT NVLWVQLDAL 

       250 
QHAYVEGHIP PGAFVPKEN

Q89FG3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools