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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0235981100; PubMed=12522265 [NCBI, ExPASy, EBI, Israel, Japan]
van Ham R.C.H.J.,
Kamerbeek J.,
Palacios C.,
Rausell C.,
Abascal F.,
Bastolla U.,
Fernandez J.M.,
Jimenez L.,
Postigo M.,
Silva F.J.,
Tamames J.,
Viguera E.,
Latorre A.,
Valencia A.,
Moran F.,
Moya A.;
"Reductive genome evolution in Buchnera aphidicola.";
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
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- FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
- CATALYTIC ACTIVITY: Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.
- COFACTOR: Thiamine pyrophosphate (By similarity).
- SUBUNIT: Homodimer (By similarity).
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 887 AA [This is the length of the unprocessed precursor] |
Molecular weight: 100906 Da [This is the MW of the unprocessed precursor] |
CRC64: 89A9A18649A6A78A [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAEFSSNDID PIETEDWIQA IKSVIREDGL ERANFIINTV KKYVPYKNKV VFKKCAISNY
70 80 90 100 110 120
VNTIPVEEEP NYPGDLFIEQ KIRSVIRWNA IMMVLRASKK NLDLGGHLSS FQSAATIYEV
130 140 150 160 170 180
CFNHFFHATN ENNGGDLVYF QGHISPGIYS RAFIEDRLTQ KQLDNFRQEI DGIGLSSYPH
190 200 210 220 230 240
PKLMPNFWQF PTVSMGLGPI CAIYQAKFLK YLEHRNLKCT NNQKVYAFLG DGEMDEPESK
250 260 270 280 290 300
GAISIAAREK LDNLIFIVNC NLQRLDGPVI GNGKVIDELE SVFKGCGWKV IKVIWGSKWD
310 320 330 340 350 360
SLLKKDVSGK LIKLMNETLD GDYQTFKSKN GAYIRKYFFG KYLETQELVK DMSDDQIWNL
370 380 390 400 410 420
DRGGHDPKKI YAALSKANSI VGKPVIILMH TVKGYGMGDI AEGKNIAHQI KKIDIKGITY
430 440 450 460 470 480
IKNRFKVPVE ENELKYLPYV SFDANSIEYK YLHARRKKLG GYLPIRLSNF TNFFTLPKLD
490 500 510 520 530 540
EFSTLLTEQK KEISTTIVFI RILNILLRNS FIKDRIVPII ADEARTFGME GLFRKIGIYN
550 560 570 580 590 600
FIGQKYTPQD KELLAYYKED KKGQILQEGI NELGAAASWL AAATSYSTNN FPMIPFYIFY
610 620 630 640 650 660
SMFGFQRIGD LFWAAGDQQA RGFLIGGTSG KTTLNGEGLQ HGDGHSHIQA LTIPNCISYN
670 680 690 700 710 720
PAYAYELAVI VHDGLQRMYG PSQENIYYYI TTMNENYVMP GISKNMYEGI CKGIYKLKHV
730 740 750 760 770 780
GKKNVKVQIM GSGSILQCVC RAAEILLEEY DIGSDVYSVT SFTELARNGQ DCDRWNLLHP
790 800 810 820 830 840
TQEKKVPFVT KIMNKLPAIA VTDYMKLFSE QVRAYIPAVT YRVLGTDGFG RSDSRKNLRR
850 860 870 880
YFEIDEYHIV IAVLGELEKI GDVDKNTIVN AISKFKIDIN KVNPRLA
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Q89AR0 in FASTA format |
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