ID   HPPD_NEUCR              Reviewed;         412 AA.
AC   Q872T7; Q1K579;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   04-NOV-2008, entry version 36.
DE   RecName: Full=4-hydroxyphenylpyruvate dioxygenase;
DE            Short=HPPDase;
DE            Short=4HPPD;
DE            Short=HPD;
DE            EC=1.13.11.27;
GN   ORFNames=B23G1.170, NCU01830;
OS   Neurospora crassa.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
OC   Neurospora.
OX   NCBI_TaxID=5141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   MEDLINE=22542210; PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V.,
RA   Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J.,
RA   Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the
RT   Neurospora genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   MEDLINE=22598136; PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
RA   Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
RA   Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C.,
RA   Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
RA   Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
RA   Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S.,
RA   Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
RA   Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
RA   Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- CATALYTIC ACTIVITY: 4-hydroxyphenylpyruvate + O(2) = homogentisate
CC       + CO(2).
CC   -!- COFACTOR: Binds 1 iron ion per subunit (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 3/6.
CC   -!- SIMILARITY: Belongs to the 4HPPD family.
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DR   EMBL; BX284754; CAD70479.1; -; Genomic_DNA.
DR   EMBL; AABX02000005; EAA27378.1; -; Genomic_DNA.
DR   RefSeq; XP_956614.1; -.
DR   GeneID; 3872761; -.
DR   KEGG; ncr:NCU01830; -.
DR   NMPDR; fig|5141.1.peg.6202; -.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR   InterPro; IPR004360; Glyas_bleo-R_dOase.
DR   PANTHER; PTHR11959; HPP_dOase; 1.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   PIRSF; PIRSF009283; HPP_dOase; 1.
DR   TIGRFAMs; TIGR01263; 4HPPD; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    412       4-hydroxyphenylpyruvate dioxygenase.
FT                                /FTId=PRO_0000088406.
FT   METAL       212    212       Iron (By similarity).
FT   METAL       295    295       Iron (By similarity).
FT   METAL       380    380       Iron (By similarity).
SQ   SEQUENCE   412 AA;  46029 MW;  147ECCF630586B9B CRC64;
     MSPSAISSEY SNCNGTPDYA LQSSEVSNFN GYDHVTWWVG NAKQAASYYN TVFGFKTLAY
     RGLETGSRYF ASYVVGNADV RFVFTSPIRS QKCLPEEEPI SDADRKLLQE CHEHLEKHGD
     AVKDVAFEVD NVDGVFHKAV AAGADVVQEP TTLTDKMHGS VRTAVIRTYG DTTHTLISRA
     DYNGPFLPGF RTAAPSSATV QLPSVPLARI DHCVGNQDWN EMVSACAFYE QCLSFHRFWS
     VDDSQICTEF SALNSIVMAS ENNLVKMPIN EPAPGKKKSQ IEEYVVFNSG AGVQHIALLT
     PDIISTVSAM RARGVEFINV PSTYYDTIRQ RLKTEKRGWE LKEDLDTIQK LNILIDYDEG
     GYLLQLFTKP LMDRPTVFIE IIQRNNFEGF GAGNFKSLFE AIEREQAERG NL
//