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UniProtKB/Swiss-Prot entry Q872T7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HPPD_NEUCR
Primary accession number Q872T7
Secondary accession number Q1K579
Integrated into Swiss-Prot on December 6, 2005
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 35)
Name and origin of the protein
Protein name 4-hydroxyphenylpyruvate dioxygenase
Synonyms HPPDase
4HPPD
HPD
EC 1.13.11.27
Gene name
ORFNames: B23G1.170, NCU01830
From
Neurospora crassa [TaxID: 5141] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1093/nar/gkg293; PubMed=12655011 [NCBI, ExPASy, EBI, Israel, Japan]
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence.";
Nucleic Acids Res. 31:1944-1954(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX284754; CAD70479.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AABX02000005; EAA27378.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_956614.1; -.
3D structure databases
ModBase Q872T7.
Family and domain databases
InterPro IPR005956; 4OHPhenylPyrv_dOase.
IPR004360; Glyas_bleo-R_dOase.
Graphical view of domain structure.
PANTHER PTHR11959; HPP_dOase; 1.
Pfam PF00903; Glyoxalase; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF009283; HPP_dOase; 1.
TIGRFAMs TIGR01263; 4HPPD; 1.
BLOCKS Q872T7.
Genome annotation databases
GeneID 3872761; -.
KEGG ncr:NCU01830; -.
NMPDR fig|5141.1.peg.6202; -.
Other
ProtoNet Q872T7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   412  412     4-hydroxyphenylpyruvate dioxygenase. PRO_0000088406
METAL   212   212        Iron (By similarity). 
METAL   295   295        Iron (By similarity). 
METAL   380   380        Iron (By similarity). 
Sequence information
Length: 412 AA [This is the length of the unprocessed precursor] Molecular weight: 46029 Da [This is the MW of the unprocessed precursor] CRC64: 147ECCF630586B9B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSPSAISSEY SNCNGTPDYA LQSSEVSNFN GYDHVTWWVG NAKQAASYYN TVFGFKTLAY 

        70         80         90        100        110        120 
RGLETGSRYF ASYVVGNADV RFVFTSPIRS QKCLPEEEPI SDADRKLLQE CHEHLEKHGD 

       130        140        150        160        170        180 
AVKDVAFEVD NVDGVFHKAV AAGADVVQEP TTLTDKMHGS VRTAVIRTYG DTTHTLISRA 

       190        200        210        220        230        240 
DYNGPFLPGF RTAAPSSATV QLPSVPLARI DHCVGNQDWN EMVSACAFYE QCLSFHRFWS 

       250        260        270        280        290        300 
VDDSQICTEF SALNSIVMAS ENNLVKMPIN EPAPGKKKSQ IEEYVVFNSG AGVQHIALLT 

       310        320        330        340        350        360 
PDIISTVSAM RARGVEFINV PSTYYDTIRQ RLKTEKRGWE LKEDLDTIQK LNILIDYDEG 

       370        380        390        400        410 
GYLLQLFTKP LMDRPTVFIE IIQRNNFEGF GAGNFKSLFE AIEREQAERG NL 

Q872T7 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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