[1]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-203 (ISOFORMS 1/2).
TISSUE=Retinoblastoma;
The MGC Project Team;
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-585 (ISOFORM 2).
TISSUE=Amygdala;
The German cDNA consortium;
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] OF 194-585 (ISOFORM 1).
TISSUE=Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[4]
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METHYLATION OF ELAVL1.
DOI=10.1074/jbc.M206187200; PubMed=12237300 [NCBI, ExPASy, EBI, Israel, Japan]
Li H.,
Park S.,
Kilburn B.,
Jelinek M.A.,
Henschen-Edman A.,
Aswad D.W.,
Stallcup M.R.,
Laird-Offringa I.A.;
"Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase.";
J. Biol. Chem. 277:44623-44630(2002).
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[5]
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TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
DOI=10.1002/cncr.20327; PubMed=15221992 [NCBI, ExPASy, EBI, Israel, Japan]
Hong H.,
Kao C.,
Jeng M.-H.,
Eble J.N.,
Koch M.O.,
Gardner T.A.,
Zhang S.,
Li L.,
Pan C.-X.,
Hu Z.,
MacLennan G.T.,
Cheng L.;
"Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.";
Cancer 101:83-89(2004).
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[6]
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INTERACTION WITH NR1H4.
DOI=10.1074/jbc.M410021200; PubMed=15471871 [NCBI, ExPASy, EBI, Israel, Japan]
Ananthanarayanan M.,
Li S.,
Balasubramaniyan N.,
Suchy F.J.,
Walsh M.J.;
"Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1.";
J. Biol. Chem. 279:54348-54357(2004).
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[7]
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METHYLATION OF EP300.
DOI=10.1073/pnas.0407159102; PubMed=15731352 [NCBI, ExPASy, EBI, Israel, Japan]
Lee Y.-H.,
Coonrod S.A.,
Kraus W.L.,
Jelinek M.A.,
Stallcup M.R.;
"Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination.";
Proc. Natl. Acad. Sci. U.S.A. 102:3611-3616(2005).
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[8]
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METHYLATION OF HISTONE H3, INTERACTION WITH RELA, AND FUNCTION.
DOI=10.1210/me.2005-0365; PubMed=16497732 [NCBI, ExPASy, EBI, Israel, Japan]
Miao F.,
Li S.,
Chavez V.,
Lanting L.,
Natarajan R.;
"Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17.";
Mol. Endocrinol. 20:1562-1573(2006).
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[9]
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INTERACTION WITH HTLV-1 TAX-1.
DOI=10.1128/JVI.00186-06; PubMed=17005681 [NCBI, ExPASy, EBI, Israel, Japan]
Jeong S.J.,
Lu H.,
Cho W.K.,
Park H.U.,
Pise-Masison C.,
Brady J.N.;
"Coactivator-associated arginine methyltransferase 1 enhances transcriptional activity of the human T-cell lymphotropic virus type 1 long terminal repeat through direct interaction with Tax.";
J. Virol. 80:10036-10044(2006).
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- FUNCTION: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' and activates transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.
- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + histone-arginine = S-adenosyl-L-homocysteine + histone-N(omega)-methyl-arginine.
- SUBUNIT: Homodimer (Probable). Interacts with the C-terminus of NCOA2/GRIP1, NCO3/ACTR and NCOA1/SRC1. Part of a complex consisting of CARM1, EP300/P300 and NCOA2/GRIP1. Interacts with FLII, TP53, myogenic factor MEF2, EP300/P300, CREBBP and CTNNB1. Interacts with SNRPC (By similarity). Interacts with NR1H4. Interacts with RELA. Interacts with HTLV-1 Tax-1.
- SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Isoform ID | Q86X55-2 |
| Note: No experimental confirmation available. |
| Features which should be applied to build the isoform sequence: VSP_012506, VSP_012507. |
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- TISSUE SPECIFICITY: Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia.
- MISCELLANEOUS: Methylation of H3-R17 by CARM1 is stimulated by preacetylation of H3-K18/H3-K23 by EP300 and blocked by citrullination of H3-R17 by PADI4 (By similarity).
- SIMILARITY: Belongs to the protein arginine N-methyltransferase family.
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