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UniProtKB/Swiss-Prot entry Q81LH2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TGT_BACAN
Primary accession number Q81LH2
Secondary accession numbers Q6HSX9 Q6KM67
Integrated into Swiss-Prot on June 7, 2005
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 39)
Name and origin of the protein
Protein name Queuine tRNA-ribosyltransferase
Synonyms EC 2.4.2.29
tRNA-guanine transglycosylase
Guanine insertion enzyme
Gene name
Name: tgt
OrderedLocusNames: BA_4647, GBAA4647, BAS4312
From
Bacillus anthracis [TaxID: 1392] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus; Bacillus cereus group.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Ames / isolate Porton;
DOI=10.1038/nature01586; PubMed=12721629 [NCBI, ExPASy, EBI, Israel, Japan]
Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.;
"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria.";
Nature 423:81-86(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Ames ancestor;
Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M.;
"Bacillus anthracis comparative genomics.";
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Sterne;
Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.;
"Complete genome sequence of Bacillus anthracis Sterne.";
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016879; AAP28350.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE017334; AAT33769.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE017225; AAT56610.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_846864.1; -.
YP_021294.1; -.
YP_030559.1; -.
3D structure databases
HSSP P28720; 1PXG. [HSSP ENTRY / PDB]
ModBase Q81LH2.
Enzyme and pathway databases
BioCyc BANT260799:BAS4312-MON; -.
BANT261594:GBAA4647-MON; -.
Ontologies
GO
GO:0008479; Molecular function: queuine tRNA-ribosyltransferase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008616; Biological process: queuosine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00168; -; 1.
PBIL [Tree]
InterPro IPR004803; QtRNA_ribo_trans.
IPR002616; tRNA_ribo_trans.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.105; tRNA_ribo_trans; 1.
PANTHER PTHR11962; tRNA_ribo_trans; 1.
Pfam PF01702; TGT; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00430; Q_tRNA_tgt; 1.
TIGR00449; tgt_general; 1.
ProtoNet Q81LH2.
Genome annotation databases
GeneID 1084870; -.
2819339; -.
2852840; -.
GenomeReviews AE016879_GR; BA_4647.
AE017225_GR; BAS4312.
AE017334_GR; GBAA4647.
KEGG ban:BA4647; -.
bar:GBAA4647; -.
bat:BAS4312; -.
TIGR BA_4647; -.
GBAA4647; -.
Phylogenomic databases
HOGENOM Q81LH2; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glycosyltransferase; Metal-binding; Queuosine biosynthesis; Transferase; tRNA processing; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   379  379     Queuine tRNA-ribosyltransferase. PRO_0000135444
ACT_SITE   94    94        Nucleophile (By similarity). 
METAL   306   306        Zinc (By similarity). 
METAL   308   308        Zinc (By similarity). 
METAL   311   311        Zinc (By similarity). 
METAL   337   337        Zinc (By similarity). 
BINDING   95    95        Substrate (By similarity). 
Sequence information
Length: 379 AA [This is the length of the unprocessed precursor] Molecular weight: 43227 Da [This is the MW of the unprocessed precursor] CRC64: 6DE1E29B88568644 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTAIRYEFIK TCKQTGARLG RVHTPHGSFD TPTFMPVGTL ATVKTMSPEE LKAMDSGIIL 

        70         80         90        100        110        120 
SNTYHLWLRP GHEIIREAGG LHKFMNWDRA ILTDSGGFQV FSLSDFRRIE EEGVHFRNHL 

       130        140        150        160        170        180 
NGDKLFLSPE KAMEIQNALG SDIMMAFDEC PPFPATFEYM KKSVERTSRW AERCLKAHER 

       190        200        210        220        230        240 
PQDQGLFGIV QGGEFEELRR QSAKDLVSMD FPGYAVGGLS VGEPKDIMNR VLEFTTPLLP 

       250        260        270        280        290        300 
DNKPRYLMGV GSPDSLIDGA IRGIDMFDCV LPTRIARNGT CMTSEGRLVV KNAKFARDFG 

       310        320        330        340        350        360 
PLDPNCDCYT CKNYSRAYIR HLMKCDETFG IRLTSYHNLH FLLNLMEQVR QAIREDRLGD 

       370 
FREEFFEQYG FNKPNAKNF 

Q81LH2 in FASTA format

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