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UniProtKB/Swiss-Prot entry Q81JJ9


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GUAC_BACAN
Primary accession number Q81JJ9
Secondary accession numbers Q6HQ42 Q6KJI6
Integrated into Swiss-Prot on March 15, 2004
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 44)
Name and origin of the protein
Protein name GMP reductase
Synonyms EC 1.7.1.7
Guanosine 5'-monophosphate oxidoreductase
Guanosine monophosphate reductase
Gene name
Name: guaC
OrderedLocusNames: BA_5705, GBAA5705, BAS5309
From
Bacillus anthracis [TaxID: 1392] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus; Bacillus cereus group.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Ames / isolate Porton;
DOI=10.1038/nature01586; PubMed=12721629 [NCBI, ExPASy, EBI, Israel, Japan]
Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L., DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolstoe A.-B., Fraser C.M.;
"The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria.";
Nature 423:81-86(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Ames ancestor;
Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B., Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L., Fraser C.M.;
"Bacillus anthracis comparative genomics.";
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Sterne;
Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K., Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R., Richardson P., Rubin E., Tice H.;
"Complete genome sequence of Bacillus anthracis Sterne.";
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016879; AAP29337.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE017334; AAT34865.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE017225; AAT57596.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_847851.1; -.
YP_022390.1; -.
YP_031546.1; -.
3D structure databases
PDB
1YPF; X-ray; 1.80 A; A/B=1-327.[ExPASy / RCSB / EBI]
2A1Y; X-ray; 2.27 A; A=1-327.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1YPF; -.
2A1Y; -.
ModBase Q81JJ9.
Enzyme and pathway databases
BioCyc BANT260799:BAS5309-MON; -.
BANT261594:GBAA5705-MON; -.
Ontologies
GO
GO:0003920; Molecular function: GMP reductase activity (inferred from electronic annotation from HAMAP).
GO:0006163; Biological process: purine nucleotide metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01511; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR005994; GMP_reduct2.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF00478; IMPDH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036500; GMP_red_Firmic; 1.
TIGRFAMs TIGR01306; GMP_reduct_2; 1.
PROSITE PS00487; IMP_DH_GMP_RED; 1.
BLOCKS Q81JJ9.
Genome annotation databases
GeneID 1085456; -.
2816139; -.
2852911; -.
GenomeReviews AE016879_GR; BA_5705.
AE017225_GR; BAS5309.
AE017334_GR; GBAA5705.
KEGG ban:BA5705; -.
bar:GBAA5705; -.
bat:BAS5309; -.
TIGR BA_5705; -.
GBAA5705; -.
Phylogenomic databases
HOGENOM Q81JJ9; -.
Other
ProtoNet Q81JJ9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   327  327     GMP reductase. PRO_0000093746
NP_BIND   204   227  24     NADP (By similarity). 
ACT_SITE   175   175        Thioimidate intermediate (By similarity). 
HELIX   7     9  3      
STRAND   10    12  3      
HELIX   22    24  3      
STRAND   29    31  3      
STRAND   34    42  9      
TURN   46    48  3      
HELIX   51    59  9      
HELIX   71    73  3      
HELIX   74    83  10      
STRAND   89    92  4      
HELIX   96   107  12      
STRAND   113   118  6      
HELIX   125   137  13      
STRAND   141   148  8      
HELIX   151   160  10      
STRAND   163   167  5      
HELIX   176   181  6      
STRAND   182   185  4      
HELIX   189   198  10      
STRAND   204   208  5      
HELIX   214   221  8      
STRAND   225   230  6      
HELIX   231   233  3      
STRAND   239   241  3      
STRAND   273   277  5      
HELIX   282   299  18      
STRAND   302   304  3      
HELIX   305   310  6      
STRAND   313   315  3      
Sequence information
Length: 327 AA [This is the length of the unprocessed precursor] Molecular weight: 36076 Da [This is the MW of the unprocessed precursor] CRC64: 8006FDFA6A5F2E78 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGNVFDYEDI QLIPAKCIVN SRSECDTTVT LGKHKFKLPV VPANMQTIID ERIATYLAEN 

        70         80         90        100        110        120 
NYFYIMHRFQ PEKRISFIRD MQSRGLIASI SVGVKEDEYE FVQQLAAEHL TPEYITIDIA 

       130        140        150        160        170        180 
HGHSNAVINM IQHIKKHLPE SFVIAGNVGT PEAVRELENA GADATKVGIG PGKVCITKIK 

       190        200        210        220        230        240 
TGFGTGGWQL AALRWCAKAA SKPIIADGGI RTNGDVAKSI RFGATMVMIG SLFAGHEESP 

       250        260        270        280        290        300 
GETIEKDGKL YKEYFGSASE FQKGEKKNVE GKKMFVEHKG SLEDTLIEME QDLQSSISYA 

       310        320 
GGTKLDSIRT VDYVVVKNSI FNGDKVY 

Q81JJ9 in FASTA format

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