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UniProtKB/Swiss-Prot entry Q81G06

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_BACCR
Primary accession number Q81G06
Secondary accession numbers None
Integrated into Swiss-Prot on April 13, 2004
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 38)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: BC_1406
From
Bacillus cereus (strain ATCC 14579 / DSM 31) [TaxID: 226900] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus; Bacillus cereus group.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature01582; PubMed=12721630 [NCBI, ExPASy, EBI, Israel, Japan]
Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G., Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.;
"Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis.";
Nature 423:87-91(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016877; AAP08387.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_831186.1; -.
3D structure databases
ModBase Q81G06.
Enzyme and pathway databases
BioCyc BCER226900:BC_1406-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q81G06.
Genome annotation databases
GeneID 1203755; -.
GenomeReviews AE016877_GR; BC_1406.
KEGG bce:BC1406; -.
Phylogenomic databases
HOGENOM Q81G06; -.
Genome annotation databases
CMR Q81G06; BC_1406.
Other
ProtoNet Q81G06.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   429  429     Histidinol dehydrogenase. PRO_0000135722
ACT_SITE   324   324        Proton acceptor (By similarity). 
ACT_SITE   325   325        Proton acceptor (By similarity). 
METAL   256   256        Zinc (By similarity). 
METAL   259   259        Zinc (By similarity). 
METAL   358   358        Zinc (By similarity). 
METAL   417   417        Zinc (By similarity). 
BINDING   127   127        NAD (By similarity). 
BINDING   188   188        NAD (By similarity). 
BINDING   211   211        NAD (By similarity). 
BINDING   234   234        Substrate (By similarity). 
BINDING   256   256        Substrate (By similarity). 
BINDING   259   259        Substrate (By similarity). 
BINDING   325   325        Substrate (By similarity). 
BINDING   358   358        Substrate (By similarity). 
BINDING   412   412        Substrate (By similarity). 
BINDING   417   417        Substrate (By similarity). 
Sequence information
Length: 429 AA [This is the length of the unprocessed precursor] Molecular weight: 47511 Da [This is the MW of the unprocessed precursor] CRC64: 421984C965563315 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEIIYEEFKE ALSKIKVLRE NANIIEETVQ RSVREIIRHV REGKDEALSF YTKKFDGVEM 

        70         80         90        100        110        120 
KNFRVSEEEI QQASMFVENS FLEALKEAKK NVVSYHEKQK KHSIFDCESK GIIRGQLIRP 

       130        140        150        160        170        180 
LENIGVYVPG GTASYPSSVL MNVLPAKLAG VKKIVMVTPP RKGGIDPHIL AAADLAGVDE 

       190        200        210        220        230        240 
IYTIGGAQAI AALAYGTESI PKVDKIVGPG NLYVALAKRE VYGIVNIDMI AGPSEIVVVA 

       250        260        270        280        290        300 
DETGNAKYIA ADLLSQAEHD ERATAICITT NMELAKEVEK EVERQLETLP RSEIARESIN 

       310        320        330        340        350        360 
RNGAIFIVPS LEEALKLSNE IAPEHLELHI KEPMNALDYV KHAGSIFLGP YSPEPLGDYL 

       370        380        390        400        410        420 
AGPNHVLPTS GTARFFSPLS VDDFVKKSSF ISYTEEALKN VQHHIVELAN KEGLHAHARA 


IQIRFEEEK
Q81G06 in FASTA format

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