[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Embryo; NIH - Xenopus Gene Collection (XGC) project; Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) (By similarity).
CATALYTIC ACTIVITY: Cholesterol + NADP⁺ = cholesta-5,7-dien-3-beta-ol + NADPH.
PATHWAY: Steroid metabolism; cholesterol biosynthesis .
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the ERG4/ERG24 family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC044995; AAH44995.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001079586.1; -.

UniGene

Xl.2547

3D structure databases

ModBase

Q7ZXH1.

Ontologies

GO:0005789;	Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.

Family and domain databases

InterPro

IPR001171; ERG4_ERG24.
Graphical view of domain structure.

Pfam

PF01222; ERG4_ERG24; 1.
Pfam graphical view of domain structure.

PROSITE

PS01017; STEROL_REDUCT_1; 1.
PS01018; STEROL_REDUCT_2; 1.

BLOCKS

Q7ZXH1.

Genome annotation databases

GeneID

379273; -.

KEGG

xla:379273; -.

Phylogenomic databases

HOVERGEN

Q7ZXH1; -.

Other

ProtoNet

Q7ZXH1.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cholesterol biosynthesis; Endoplasmic reticulum; Lipid synthesis; Membrane; NADP; Oxidoreductase; Steroid biosynthesis; Sterol biosynthesis; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 473`	`473`	`7-dehydrocholesterol reductase.`	`PRO_0000207506`
`TRANSMEM`	`36 56`	`21`	`Potential.`
`TRANSMEM`	`97 117`	`21`	`Potential.`
`TRANSMEM`	`175 195`	`21`	`Potential.`
`TRANSMEM`	`264 284`	`21`	`Potential.`
`TRANSMEM`	`304 324`	`21`	`Potential.`
`TRANSMEM`	`329 349`	`21`	`Potential.`
`TRANSMEM`	`419 439`	`21`	`Potential.`

Sequence information

Length: 473 AA [This is the length of the unprocessed precursor]

Molecular weight: 54823 Da [This is the MW of the unprocessed precursor]

CRC64: 8EB14E8186BDC463 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGERRRANAS RGDKKVANGE KQHVGQWGRA WEVDYFSLAS VIFLLAFAPL IVYYFVMSCD 

        70         80         90        100        110        120 
QYQCALTAPV LDLYSGKARL SDIWDKTPAL TWTAVKIYLA WVSFQVFLYM FLPDILHKFV 

       130        140        150        160        170        180 
PGYEGGVQEG ARTPAGLINK YQVNGLQAWT ITHLLWFANA YHFHWFSPTI VIDNWIPLLW 

       190        200        210        220        230        240 
CANLLGYSVA TFALVKANFF PTNANDCKFT GNFFYDYMMG IEFNPRIGKW FDFKLFFNGR 

       250        260        270        280        290        300 
PGIVAWTLIN LSYAAKQQEL YGQVTNSMIL VNVLQAIYVV DFFWNESWYL KTIDICHDHF 

       310        320        330        340        350        360 
GWYLGWGDCV WLPYLYTLQG LYLVYNPVEL STTAAVAVLL LGLIGYYIFR MTNHQKDLFR 

       370        380        390        400        410        420 
RTNGNCKIWG KKPKSIECFY VSADGKRHYS KLMISGFWGV ARHLNYTGDL MGSLAYCLAC 

       430        440        450        460        470 
GFDHLLPYFY FIYMTILLVH RCIRDEHRCS SKYGKDWKLY TSAVPYRLLP GLF

Q7ZXH1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools