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UniProtKB/Swiss-Prot entry Q7WGE4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRD_BORBR
Primary accession number Q7WGE4
Secondary accession numbers None
Integrated into Swiss-Prot on August 30, 2005
Sequence was last modified on October 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 37)
Name and origin of the protein
Protein name Dihydroorotate dehydrogenase
Synonyms EC 1.3.3.1
Dihydroorotate oxidase
DHOdehase
DHODase
DHOD
Gene name
Name: pyrD
OrderedLocusNames: BB3975
From
Bordetella bronchiseptica (Alcaligenes bronchisepticus) [TaxID: 518] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Bordetella.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=RB50 / ATCC BAA-588 / NCTC 13252;
DOI=10.1038/ng1227; PubMed=12910271 [NCBI, ExPASy, EBI, Israel, Japan]
Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.;
"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.";
Nat. Genet. 35:32-40(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX640449; CAE34338.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_890509.1; -.
3D structure databases
HSSP P05021; 1F76. [HSSP ENTRY / PDB]
ModBase Q7WGE4.
Enzyme and pathway databases
BioCyc BBRO257310:BB3975-MON; -.
Ontologies
GO
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from HAMAP).
GO:0004158; Molecular function: dihydroorotate oxidase activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00225; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR012135; DHO_DHase_1_2.
IPR005719; DHO_DHase_2.
IPR001295; Dihydroorotate_DHase_core.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF01180; DHO_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000164; DHO_oxidase; 1.
TIGRFAMs TIGR01036; pyrD_sub2; 1.
PROSITE PS00911; DHODEHASE_1; 1.
PS00912; DHODEHASE_2; 1.
BLOCKS Q7WGE4.
Genome annotation databases
GeneID 2662207; -.
GenomeReviews BX470250_GR; BB3975.
KEGG bbr:BB3975; -.
NMPDR fig|257310.1.peg.3956; -.
Phylogenomic databases
HOGENOM Q7WGE4; -.
Genome annotation databases
CMR Q7WGE4; BB3975.
Other
ProtoNet Q7WGE4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Complete proteome; Flavoprotein; FMN; Membrane; Oxidoreductase; Pyrimidine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   349  349     Dihydroorotate dehydrogenase. PRO_0000148423
ACT_SITE   183   183        Nucleophile (By similarity). 
Sequence information
Length: 349 AA [This is the length of the unprocessed precursor] Molecular weight: 37017 Da [This is the MW of the unprocessed precursor] CRC64: BE6C5634D87A135A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSILFHAYPL ARPALFAMDA ETAHEVTLAQ LQRAYDCGLT RKLLHAQPEA PATLMGLSLR 

        70         80         90        100        110        120 
NPVGLAAGLD KNGAHIDALG NLGFGFVEVG TVTPRAQPGN PKPRMFRLPR ANALINRLGF 

       130        140        150        160        170        180 
NNQGLDAFIA NVQRSQWRSQ GGILGLNIGK NADTPIERAA EDYLIGLAGV YPHADYVTVN 

       190        200        210        220        230        240 
ISSPNTKNLR ALQGGDELSA LLGQLQERRL ALADQHQRHV PLAVKIAPDL SDDQIDAIAE 

       250        260        270        280        290        300 
ILPRHGIDGV IATNTTLARD AVQGLPHAEE AGGVSGAPVH ELSLRVIERL RSRLGDAVAI 

       310        320        330        340 
IGVGGILSGR QASEKMAAGA QAVQLYTGLI YRGPALVGEC VRALAQGSR 

Q7WGE4 in FASTA format

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