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UniProtKB/Swiss-Prot entry Q7VUG2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HGD_BORPE
Primary accession number Q7VUG2
Secondary accession numbers None
Integrated into Swiss-Prot on March 7, 2006
Sequence was last modified on October 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 30)
Name and origin of the protein
Protein name Homogentisate 1,2-dioxygenase
Synonyms EC 1.13.11.5
Homogentisicase
Homogentisate oxygenase
Homogentisic acid oxidase
Gene name
Name: hmgA
OrderedLocusNames: BP3134
From
Bordetella pertussis [TaxID: 520] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Bordetella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
DOI=10.1038/ng1227; PubMed=12910271 [NCBI, ExPASy, EBI, Israel, Japan]
Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.;
"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.";
Nat. Genet. 35:32-40(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX640420; CAE43401.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_881699.1; -.
3D structure databases
HSSP Q93099; 1EYB. [HSSP ENTRY / PDB]
ModBase Q7VUG2.
Enzyme and pathway databases
BioCyc BPER257313:BP3134-MON; -.
Ontologies
GO
GO:0004411; Molecular function: homogentisate 1,2-dioxygenase activity (inferred from electronic annotation from HAMAP).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from HAMAP).
GO:0006559; Biological process: L-phenylalanine catabolic process (inferred from electronic annotation from HAMAP).
GO:0006572; Biological process: tyrosine catabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00334; -; 1.
PBIL [Tree]
InterPro IPR005708; Homogentis_dOase.
Graphical view of domain structure.
PANTHER PTHR11056; Homogentis_dOase; 1.
Pfam PF04209; HgmA; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01015; hmgA; 1.
BLOCKS Q7VUG2.
Genome annotation databases
GeneID 2666382; -.
GenomeReviews BX470248_GR; BP3134.
KEGG bpe:BP3134; -.
NMPDR fig|257313.1.peg.2771; -.
Phylogenomic databases
HOGENOM Q7VUG2; -.
Genome annotation databases
CMR Q7VUG2; BP3134.
Other
ProtoNet Q7VUG2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   432  432     Homogentisate 1,2-dioxygenase. PRO_0000225784
METAL   329   329        Iron (By similarity). 
METAL   335   335        Iron (By similarity). 
METAL   365   365        Iron (By similarity). 
Sequence information
Length: 432 AA [This is the length of the unprocessed precursor] Molecular weight: 48046 Da [This is the MW of the unprocessed precursor] CRC64: 518A054ED0EE3F96 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSLHYQTGFG NACATEALPG ALPAGRNSPQ ICPYGLYAEQ LSGTAFTAPR AENRRSWLYR 

        70         80         90        100        110        120 
IRPGVQHLPF APFAGAQRWL SDFGRQPVTP NQLRWSPLPM PDAPTDFIDG MHTWGGNGGP 

       130        140        150        160        170        180 
EEQSGVGIHL YAANRSMQGR FFYNADGEML IVPQQGRLRL ATELGLIDIE PYEIAVVPRG 

       190        200        210        220        230        240 
VRLRVELLDD VARGYVLENF GTAMRLPELG PIGSNCLANA RDFQIPVAWY EDVEGDFELI 

       250        260        270        280        290        300 
AKFTGGFWRA PITHSPLNVV AWHGTHAPYK YDLRNFNTVG SISYDHPDPS IFTVLTSPSD 

       310        320        330        340        350        360 
TPGTANMDFA IFPPRILAME NTFRPPWFHR NIASEFMGLI HGVYDAKAEG FAPGGASLHN 

       370        380        390        400        410        420 
CMSGHGPDAD TFEKASHADT SQAHYIRDTM AFMFETRRVI RPTAQALASP QRQDDYYQCW 

       430 
QGLQKHFDPE QA
Q7VUG2 in FASTA format

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