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UniProtKB/Swiss-Prot entry Q7VSZ1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_BORPE
Primary accession number Q7VSZ1
Secondary accession numbers None
Integrated into Swiss-Prot on April 13, 2004
Sequence was last modified on October 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 33)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: BP3768
From
Bordetella pertussis [TaxID: 520] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Bordetella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
DOI=10.1038/ng1227; PubMed=12910271 [NCBI, ExPASy, EBI, Israel, Japan]
Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.;
"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.";
Nat. Genet. 35:32-40(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX640422; CAE44024.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_882269.1; -.
3D structure databases
ModBase Q7VSZ1.
Enzyme and pathway databases
BioCyc BPER257313:BP3768-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
IPR002035; VWF_A.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
PR00453; VWFADOMAIN.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q7VSZ1.
Genome annotation databases
GeneID 2665051; -.
GenomeReviews BX470248_GR; BP3768.
KEGG bpe:BP3768; -.
Phylogenomic databases
HOGENOM Q7VSZ1; -.
Genome annotation databases
CMR Q7VSZ1; BP3768.
Other
ProtoNet Q7VSZ1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   434  434     Histidinol dehydrogenase. PRO_0000135738
ACT_SITE   330   330        Proton acceptor (By similarity). 
ACT_SITE   331   331        Proton acceptor (By similarity). 
METAL   262   262        Zinc (By similarity). 
METAL   265   265        Zinc (By similarity). 
METAL   364   364        Zinc (By similarity). 
METAL   423   423        Zinc (By similarity). 
BINDING   133   133        NAD (By similarity). 
BINDING   194   194        NAD (By similarity). 
BINDING   217   217        NAD (By similarity). 
BINDING   240   240        Substrate (By similarity). 
BINDING   262   262        Substrate (By similarity). 
BINDING   265   265        Substrate (By similarity). 
BINDING   331   331        Substrate (By similarity). 
BINDING   364   364        Substrate (By similarity). 
BINDING   418   418        Substrate (By similarity). 
BINDING   423   423        Substrate (By similarity). 
Sequence information
Length: 434 AA [This is the length of the unprocessed precursor] Molecular weight: 46136 Da [This is the MW of the unprocessed precursor] CRC64: D2D494FB6AE5EB6A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MALINRLDSR DPGFKTALSQ LLAFEAEQDE SIDQAAAGIL ADVRRRGDAA LLEYTQRFDR 

        70         80         90        100        110        120 
LAVDDATALE IPQADWHAAL DSLPAAQRQA LEAAAARVRA YHERQRGETW TYTEADGTML 

       130        140        150        160        170        180 
GQQITALDRV GLYVPGGKAA YPSSVLMNAI PAKVAGVPEL IMVTPTPDGV RNPIVLAAAA 

       190        200        210        220        230        240 
IAGVDRAFAI GGAQAVGALA YGTATVPAVD KIVGPGNAYV AAAKRRVFGT VGIDMIAGPS 

       250        260        270        280        290        300 
EILVICDGKT PADWIAMDLF SQAEHDELAQ SILLCPDAAF LAEVEAAIER LLPGMPRADI 

       310        320        330        340        350        360 
LRVSLANRGA LILVRDLEEA CAIANDIAPE HLEISTEQPQ RWTALIRHAG AIFMGRYSSE 

       370        380        390        400        410        420 
ALGDYCAGPN HVLPTSRTAR FSSPLGVYDF QKRSSLIQVS REGAQTLGRI AAELALGEGL 

       430 
QAHAASAQYR LDQP
Q7VSZ1 in FASTA format

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