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UniProtKB/Swiss-Prot entry Q7VQJ7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LEU3_BLOFL
Primary accession number Q7VQJ7
Secondary accession numbers None
Integrated into Swiss-Prot on December 15, 2003
Sequence was last modified on October 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 36)
Name and origin of the protein
Protein name 3-isopropylmalate dehydrogenase
Synonyms EC 1.1.1.85
Beta-IPM dehydrogenase
IMDH
3-IPM-DH
Gene name
Name: leuB
OrderedLocusNames: Bfl132
From
Blochmannia floridanus [TaxID: 203907] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; ant endosymbionts; Candidatus Blochmannia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.1533499100; PubMed=12886019 [NCBI, ExPASy, EBI, Israel, Japan]
Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F., Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B., van Ham R.C.H.J., Gross R., Moya A.;
"The genome sequence of Blochmannia floridanus: comparative analysis of reduced genomes.";
Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX248583; CAD83653.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_878438.1; -.
3D structure databases
ModBase Q7VQJ7.
Enzyme and pathway databases
BioCyc CBLO203907:BFL132-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003862; Molecular function: 3-isopropylmalate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009098; Biological process: leucine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01033; -; 1.
PBIL [Tree]
InterPro IPR004429; 3-isopropylmalate_DHase.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF13; IPMDH; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00169; leuB; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q7VQJ7.
Genome annotation databases
GeneID 1499332; -.
GenomeReviews BX248583_GR; Bfl132.
KEGG bfl:Bfl132; -.
Phylogenomic databases
HOGENOM Q7VQJ7; -.
Genome annotation databases
CMR Q7VQJ7; Bfl132.
Other
ProtoNet Q7VQJ7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   364  364     3-isopropylmalate dehydrogenase. PRO_0000083647
NP_BIND   79    92  14     NAD (By similarity). 
NP_BIND   286   298  13     NAD (By similarity). 
METAL   228   228        Magnesium or manganese (By similarity). 
METAL   252   252        Magnesium or manganese (By similarity). 
METAL   256   256        Magnesium or manganese (By similarity). 
BINDING   100   100        Substrate (By similarity). 
BINDING   110   110        Substrate (By similarity). 
BINDING   139   139        Substrate (By similarity). 
BINDING   228   228        Substrate (By similarity). 
SITE   146   146  1     Important for catalysis (By similarity). 
SITE   196   196  1     Important for catalysis (By similarity). 
Sequence information
Length: 364 AA [This is the length of the unprocessed precursor] Molecular weight: 40485 Da [This is the MW of the unprocessed precursor] CRC64: 144A37D7F5B028F6 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNNNTYHIAI LPGDGIGPEI MQQAYKILNT VKNKFKINII TTEYKVGGNA LDLEGSPLPK 

        70         80         90        100        110        120 
DTIKNCEKSN AILFGAVGGP KWNNINETSR PEFGALLTLR KHFNLFINLR PIYLPIELIN 

       130        140        150        160        170        180 
LSPLKPEIIS QGLDMICIRE LIGGIYFGKP QGKSGIRSQE HAFDTAIYHR FEIERIAHFA 

       190        200        210        220        230        240 
FKLAQKRRKH VTSIDKANVL HTSMLWRKVV SEVASNYPNV HLQHLYVDNA SMQLIRNPSA 

       250        260        270        280        290        300 
FDVILCPNLF GDILSDECAE INGSIGILPS ASLNEHNFGL YEPAGGSAPD IAGKNIANPI 

       310        320        330        340        350        360 
AQILSTALLF RYSLKLNHVA ITIEKAVYKA LTLGYRTQDI AYNKQKSVNT DDMGDIIASL 


IYKL
Q7VQJ7 in FASTA format

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