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UniProtKB/Swiss-Prot entry Q7NZV7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CYSG_CHRVO
Primary accession number Q7NZV7
Secondary accession numbers None
Integrated into Swiss-Prot on April 29, 2008
Sequence was last modified on December 15, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 34)
Name and origin of the protein
Protein name Siroheme synthase
Synonyms None
Includes Uroporphyrinogen-III C-methyltransferase
     (Urogen III methylase)
     (EC 2.1.1.107)
     (SUMT)
     (Uroporphyrinogen III methylase)
     (UROM)
Precorrin-2 dehydrogenase
     (EC 1.3.1.76)
Sirohydrochlorin ferrochelatase
     (EC 4.99.1.4)
Gene name
Name: cysG
Synonyms: cobA2
OrderedLocusNames: CV_0813
From
Chromobacterium violaceum [TaxID: 536] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae; Chromobacterium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 12472 / DSM 30191 / IFO 12614 / JCM 1249 / NCIB 9131;
DOI=10.1073/pnas.1832124100; PubMed=14500782 [NCBI, ExPASy, EBI, Israel, Japan]
Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T., Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R., Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F., Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S., Belo A., van den Berg C., Bogo M., Bonatto S., Bordignon J., Brigido M.M., Brito C.A., Brocchi M., Burity H.A., Camargo A.A., Cardoso D.D.P., Carneiro N.P., Carraro D.M., Carvalho C.M.B., Cascardo J.C.M., Cavada B.S., Chueire L.M.O., Creczynski-Pasa T.B., Cunha-Junior N.C., Fagundes N., Falcao C.L., Fantinatti F., Farias I.P., Felipe M.S.S., Ferrari L.P., Ferro J.A., Ferro M.I.T., Franco G.R., Freitas N.S.A., Furlan L.R., Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B., Grattapaglia D., Grisard E.C., Hanna E.S., Jardim S.N., Laurino J., Leoi L.C.T., Lima L.F.A., Loureiro M.F., Lyra M.C.C.P., Madeira H.M.F., Manfio G.P., Maranhao A.Q., Martins W.S., di Mauro S.M.Z., de Medeiros S.R.B., Meissner R.V., Moreira M.A.M., Nascimento F.F., Nicolas M.F., Oliveira J.G., Oliveira S.C., Paixao R.F.C., Parente J.A., Pedrosa F.O., Pena S.D.J., Pereira J.O., Pereira M., Pinto L.S.R.C., Pinto L.S., Porto J.I.R., Potrich D.P., Ramalho-Neto C.E., Reis A.M.M., Rigo L.U., Rondinelli E., Santos E.B.P., Santos F.R., Schneider M.P.C., Seuanez H.N., Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R., Simoes I.C., Simon D., Soares C.M.A., Soares R.B.A., Souza E.M., Souza K.R.L., Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R., Urmenyi T., Vettore A., Wassem R., Zaha A., Simpson A.J.G.;
"The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability.";
Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016825; AAQ58488.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_900483.1; -.
3D structure databases
HSSP P25924; 1PJT. [HSSP ENTRY / PDB]
ModBase Q7NZV7.
Enzyme and pathway databases
BioCyc CVIO243365:CV_0813-MONOMER; -.
Ontologies
GO
GO:0043115; Molecular function: precorrin-2 dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0051266; Molecular function: sirohydrochlorin ferrochelatase activity (inferred from electronic annotation from EC).
GO:0004851; Molecular function: uroporphyrin-III C-methyltransferase activity (inferred from electronic annotation from HAMAP).
GO:0009236; Biological process: cobalamin biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0019354; Biological process: siroheme biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01646; -; 1.
PBIL [Tree]
InterPro IPR000878; 4pyrrol_Mease.
IPR014777; 4pyrrole_Mease_sub1.
IPR014776; 4pyrrole_Mease_sub2.
IPR006366; CobA_cysG_C.
IPR006367; CysG_synth_N.
IPR016040; NAD(P)-bd.
IPR003043; Uropor_MeTrfase_CS.
Graphical view of domain structure.
Gene3D G3DSA:3.40.1010.10; 4pyrrole_Mease_sub1; 1.
G3DSA:3.30.950.10; 4pyrrole_Mease_sub2; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00590; TP_methylase; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01469; cobA_cysG_Cterm; 1.
TIGR01470; cysG_Nterm; 1.
PROSITE PS00839; SUMT_1; FALSE_NEG.
PS00840; SUMT_2; 1.
BLOCKS Q7NZV7.
Genome annotation databases
GeneID 2549239; -.
GenomeReviews AE016825_GR; CV_0813.
KEGG cvi:CV_0813; -.
NMPDR fig|243365.1.peg.813; -.
Phylogenomic databases
HOGENOM Q7NZV7; -.
Genome annotation databases
CMR Q7NZV7; CV_0813.
Other
ProtoNet Q7NZV7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cobalamin biosynthesis; Complete proteome; Lyase; Methyltransferase; Multifunctional enzyme; NAD; Oxidoreductase; Porphyrin biosynthesis; S-adenosyl-L-methionine; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   470  470     Siroheme synthase. PRO_0000330500
REGION   218   460  243     Uroporphyrinogen-III C-methyltransferase. 
Sequence information
Length: 470 AA [This is the length of the unprocessed precursor] Molecular weight: 50153 Da [This is the MW of the unprocessed precursor] CRC64: F01C33E2DE5D1B19 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEFFPIFLKL RHQRCLLVGG GEVALRKARL LLAAGASLQV VAPELAPELA DLAERGELEH 

        70         80         90        100        110        120 
LPGRYAPALL DGMRLAVAAT DDAEVNRAVA ADAEARGILV NVVDDAEASR YISPAIIDRS 

       130        140        150        160        170        180 
PLMVAVASGG SVPVLARSIR ARLESLIPAG YGRLARFGSS FRDAVKARFP DVDARRRFWE 

       190        200        210        220        230        240 
TVLEGPLADA VMNGDEAAAR AEMEKRIAAG GADRAGAVYL VGAGPGNPDL LTFRALRLMQ 

       250        260        270        280        290        300 
QADVVLYDKL VAPELLELVR RDAERVYVGK ARANHALPQD DINQLLVDLA RQGKRVLRLK 

       310        320        330        340        350        360 
GGDPFTFGRG GEEIATLAEH GIAFEVVPGI TSASGAAAYA GIPLTHRDYA QSVTFVTGHK 

       370        380        390        400        410        420 
QDGSIDLDWQ ALTRPQQTVV VYMGVSTAAE LCQAFVDNGR AASTPAAAVE WATTERQRTV 

       430        440        450        460        470 
CGTLAALPGL MASHGIASPA LIIVGEVVEL ADKLSWYRRS ENSAVTIQED 

Q7NZV7 in FASTA format

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View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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