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UniProtKB/Swiss-Prot entry Q7MJC0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAO12_VIBVY
Primary accession number Q7MJC0
Secondary accession numbers None
Integrated into Swiss-Prot on December 6, 2005
Sequence was last modified on December 15, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 33)
Name and origin of the protein
Protein name NAD-dependent malic enzyme 2
Synonyms NAD-ME 2
EC 1.1.1.38
Gene name
Name: sfcA2
OrderedLocusNames: VV2242
From
Vibrio vulnificus (strain YJ016) [TaxID: 196600] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1101/gr.1295503; PubMed=14656965 [NCBI, ExPASy, EBI, Israel, Japan]
Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L., Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P., Lee C.-T., Hor L.-I., Tsai S.-F.;
"Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
Genome Res. 13:2577-2587(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000037; BAC95006.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_935035.1; -.
3D structure databases
HSSP P27443; 1O0S. [HSSP ENTRY / PDB]
ModBase Q7MJC0.
Enzyme and pathway databases
BioCyc VVUL196600:VV2242-MON; -.
Ontologies
GO
GO:0016619; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01619; -; 1.
PBIL [Tree]
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS Q7MJC0.
Genome annotation databases
GeneID 2625048; -.
GenomeReviews BA000037_GR; VV2242.
KEGG vvy:VV2242; -.
NMPDR fig|196600.1.peg.2310; -.
Phylogenomic databases
HOGENOM Q7MJC0; -.
Genome annotation databases
CMR Q7MJC0; VV2242.
Other
ProtoNet Q7MJC0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   559  559     NAD-dependent malic enzyme 2. PRO_0000160239
ACT_SITE   98    98        Proton donor (By similarity). 
ACT_SITE   169   169        Proton acceptor (By similarity). 
METAL   240   240        Divalent metal cation (By similarity). 
METAL   241   241        Divalent metal cation (By similarity). 
METAL   264   264        Divalent metal cation (By similarity). 
BINDING   151   151        NAD (By similarity). 
BINDING   264   264        NAD (By similarity). 
BINDING   413   413        NAD (By similarity). 
SITE   264   264  1     Important for activity (By similarity). 
Sequence information
Length: 559 AA [This is the length of the unprocessed precursor] Molecular weight: 62073 Da [This is the MW of the unprocessed precursor] CRC64: 402FC1DAC6689471 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSKKMFIRQA GNTLLNTPLL NKGSAFTLEE RKNFNLIGLL PANIETIDEQ VSRAYEQFSL 

        70         80         90        100        110        120 
FNSAMEKHIY LRNIQDTNET LYFRLINQHI EEMMPIIYTP TVGEACQKFS QIYRRNRGLF 

       130        140        150        160        170        180 
LSFEDQDELE AILNNAPNTH VKVIVITDGE RILGLGDQGI GGMGIPIGKL ALYTACGGIS 

       190        200        210        220        230        240 
PEHTLPIVLD VGTNNSALLS DPMYMGWRHP RITGDQYDDF VDDCLKAIRR RWPNALIQFE 

       250        260        270        280        290        300 
DFAQANAMPL LMRYQNQFCC FNDDIQGTAS VTVGTLLAAA HATGKKLSAQ KVLFAGAGSA 

       310        320        330        340        350        360 
GCGIAEAIVA QMVSEGISVQ QARSQVFMVD RWGMLEQEMP NLLPFQKPLA QPASLRTEWQ 

       370        380        390        400        410        420 
IEANREISLL DVIQHAHPDV LIGVTGVPGL FNQEIIEAMA EDCERPVVMP LSNPTSRVEA 

       430        440        450        460        470        480 
KPEDILMWTQ GQAIVATGSP FPDVVLAGKR YPIAQCNNSY IFPGVGLGVI SANAHRVTNE 

       490        500        510        520        530        540 
MLQQASITLA SLSPMLNGGN MLLPPLSEIQ NVSRKIALEV AKKAVEQGKA SHRTEERLLE 

       550 
RIDEEFWYAQ YCEYRRIAS
Q7MJC0 in FASTA format

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