NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Liver;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Catalyzes the synthesis of the excitotoxin quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. The direct product of the reaction spontaneously rearranges to QUIN (By similarity).
CATALYTIC ACTIVITY: 3-hydroxyanthranilate + O₂ = 2-amino-3-carboxymuconate semialdehyde.
COFACTOR: Fe(2+) ion (By similarity).
SUBUNIT: Monomer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the 3-HAO family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC012872; AAH12872.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC094021; AAH94021.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_079601.1; -.

UniGene

Mm.30100

3D structure databases

ModBase

Q78JT3.

PTM databases

PhosphoSite

Q78JT3; -.

Organism-specific databases

MGI

MGI:1349444; Haao.

Gene expression databases

ArrayExpress

Q78JT3; -.

CleanEx

MM_HAAO; -.

GermOnline

ENSMUSG00000000673; Mus musculus.

Ontologies

GO:0000334;	Molecular function: 3-hydroxyanthranilate 3,4-dioxygenase activity (inferred from direct assay from MGI).
QuickGo view.

Family and domain databases

InterPro

IPR010329; 3hydroanth_dOase.
IPR016700; 3hydroanth_dOase_met.
Graphical view of domain structure.

Pfam

PF06052; 3-HAO; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF017681; 3hydroanth_dOase_animal; 1.

TIGRFAMs

TIGR03037; anthran_nbaC; 1.

BLOCKS

Q78JT3.

Genome annotation databases

Ensembl

ENSMUSG00000000673; Mus musculus. [Contig view]

GeneID

107766; -.

KEGG

mmu:107766; -.

Phylogenomic databases

HOGENOM

Q78JT3; -.

HOVERGEN

Q78JT3; -.

Other

Haao; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Dioxygenase; Iron; Metal-binding; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 286`	`286`	`3-hydroxyanthranilate 3,4-dioxygenase.`	`PRO_0000064373`
`METAL`	`47 47`		`Iron; catalytic (By similarity).`
`METAL`	`53 53`		`Iron; catalytic (By similarity).`
`METAL`	`91 91`		`Iron; catalytic (By similarity).`
`BINDING`	`43 43`		`Dioxygen (By similarity).`
`BINDING`	`53 53`		`Substrate (By similarity).`
`BINDING`	`95 95`		`Substrate (By similarity).`
`BINDING`	`105 105`		`Substrate (By similarity).`

Sequence information

Length: 286 AA [This is the length of the unprocessed precursor]

Molecular weight: 32804 Da [This is the MW of the unprocessed precursor]

CRC64: CD8A706EE264B4CD [This is a checksum on the sequence]

        10         20         30         40         50         60 
MERRVRVKSW VEENRASFQP PVCNKLMHQE QLKIMFVGGP NTRKDYHIEE GEEVFYQLEG 

        70         80         90        100        110        120 
DMILRVLEQG QHRDVPIRQG EIFLLPARVP HSPQRFANTM GLVIERRRLE SELDGLRYYV 

       130        140        150        160        170        180 
GDTEDVLFEK WFHCKDLGTQ LAPIIQEFFH SEQYRTGKPN PDQLLKELPF PLNTRSIMKP 

       190        200        210        220        230        240 
MSLKAWLDGH SRELQAGTSL SLFGDSYETQ VIAHGQGSSK GPRQDVDVWL WQQEGSSKVT 

       250        260        270        280 
MGGQCIALAP DDSLLVPAGT SYVWERAQGS VALSVTQDPA RKKPWW

Q78JT3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools