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UniProtKB/Swiss-Prot entry Q76NV5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HPPD_DICDI
Primary accession number Q76NV5
Secondary accession numbers Q1ZXJ9 Q54ZM7
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 23)
Name and origin of the protein
Protein name 4-hydroxyphenylpyruvate dioxygenase
Synonyms EC 1.13.11.27
4-hydroxyphenylpyruvic acid oxidase
HPPDase
4HPPD
HPD
Gene name
Name: hpd
ORFNames: DDB_0231604
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature00847; PubMed=12097910 [NCBI, ExPASy, EBI, Israel, Japan]
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.;
"Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
Nature 418:79-85(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
[3]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
DOI=10.1021/pr050350q; PubMed=16512674 [NCBI, ExPASy, EBI, Israel, Japan]
Reinders Y., Schulz I., Graef R., Sickmann A.;
"Identification of novel centrosomal proteins in Dictyostelium discoideum by comparative proteomic approaches.";
J. Proteome Res. 5:589-598(2006).
[4]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
DOI=10.1074/mcp.M600113-MCP200; PubMed=16926386 [NCBI, ExPASy, EBI, Israel, Japan]
Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T.;
"Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake.";
Mol. Cell. Proteomics 5:2228-2243(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AC117081; AAS38823.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AAFI02000020; EAL68718.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AAFI02000020; EAS66903.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_001134587.1; -.
XP_642615.1; -.
3D structure databases
ModBase Q76NV5.
Organism-specific databases
dictyBase DDB0231604; hpd.
Family and domain databases
InterPro IPR005956; 4OHPhenylPyrv_dOase.
IPR004360; Glyas_bleo-R_dOase.
Graphical view of domain structure.
PANTHER PTHR11959; HPP_dOase; 1.
Pfam PF00903; Glyoxalase; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF009283; HPP_dOase; 1.
TIGRFAMs TIGR01263; 4HPPD; 1.
BLOCKS Q76NV5.
Genome annotation databases
GeneID 3393771; -.
KEGG ddi:DDB_0231604; -.
Other
ProtoNet Q76NV5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   367  367     4-hydroxyphenylpyruvate dioxygenase. PRO_0000327996
METAL   169   169        Iron (By similarity). 
METAL   252   252        Iron (By similarity). 
METAL   335   335        Iron (By similarity). 
VAR_SEQ   1     1        M -> MEM (in isoform 2). VSP_032743
Sequence information
Length: 367 AA [This is the length of the unprocessed precursor] Molecular weight: 41738 Da [This is the MW of the unprocessed precursor] CRC64: EC5A1D87AB196355 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEGFDHVTFW VGNALQAATY YIARFGFQNL AYSGLETGNR QFATHVIHQN NIIMAFTSPL 

        70         80         90        100        110        120 
TGDNKDYADH MMRHGDGVKD IAFNVKDVQH IYDEAVKAGA QSVKEPHQIK DEHGIVTLAT 

       130        140        150        160        170        180 
IMSPYGETTH TFVDRSQYKG AFLPGFTYKV ASDPLSNITE PVGLNLIDHV VSNHADKMME 

       190        200        210        220        230        240 
PVVQWYEKVL QFHRFWSVDD KTIHTEYSSL RSVVVADKSE KVKLPINEPA NGIRKSQIQE 

       250        260        270        280        290        300 
YVDFYNGAGV QHIALKTDNI IDAISKLRSR GVSFLTVPKT YYTSLREKLQ HSSLEIKEDL 

       310        320        330        340        350        360 
DTLEKLHILI DYDDKGYLLQ IFTNNVEDKP TVFFEIIQRN NHDGFGAGNF KSLFEAIERQ 


QETRGNL 

Q76NV5 in FASTA format

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