ID   TY3H_CANFA              Reviewed;         495 AA.
AC   Q76IQ3;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-NOV-2008, entry version 27.
DE   RecName: Full=Tyrosine 3-monooxygenase;
DE            EC=1.14.16.2;
DE   AltName: Full=Tyrosine 3-hydroxylase;
DE            Short=TH;
GN   Name=TH;
OS   Canis familiaris (Dog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT CYS-33.
RC   STRAIN=Beagle; TISSUE=Brain;
RX   PubMed=16210796; DOI=10.1292/jvms.67.861;
RA   Takeuchi Y., Hashizume C., Chon E.M.H., Momozawa Y., Masuda K.,
RA   Kikusui T., Mori Y.;
RT   "Canine tyrosine hydroxylase (TH) gene and dopamine beta-hydroxylase
RT   (DBH) gene: their sequences, genetic polymorphisms, and diversities
RT   among five different dog breeds.";
RL   J. Vet. Med. Sci. 67:861-867(2005).
CC   -!- FUNCTION: Plays an important role in the physiology of adrenergic
CC       neurons (By similarity).
CC   -!- CATALYTIC ACTIVITY: L-tyrosine + tetrahydrobiopterin + O(2) = 3,4-
CC       dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin.
CC   -!- COFACTOR: Fe(2+) ion.
CC   -!- ENZYME REGULATION: Phosphorylation leads to an increase in the
CC       catalytic activity.
CC   -!- PATHWAY: Catecholamine biosynthesis; dopamine biosynthesis;
CC       dopamine from L-tyrosine: step 1/2.
CC   -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC       hydroxylase family.
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DR   EMBL; AB097058; BAC82588.1; -; mRNA.
DR   RefSeq; NP_001002966.1; -.
DR   UniGene; Cfa.3446; -.
DR   SMR; Q76IQ3; 158-494.
DR   Ensembl; ENSCAFG00000010099; Canis familiaris.
DR   GeneID; 403444; -.
DR   KEGG; cfa:403444; -.
DR   HOVERGEN; Q76IQ3; -.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004511; F:tyrosine 3-monooxygenase activity; IEA:InterPro.
DR   GO; GO:0009072; P:aromatic amino acid family metabolic process; IEA:InterPro.
DR   GO; GO:0042423; P:catecholamine biosynthetic process; IEA:InterPro.
DR   GO; GO:0042136; P:neurotransmitter biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001273; Aaa_hydroxylase.
DR   InterPro; IPR005962; Tyr_3_mOase.
DR   Gene3D; G3DSA:1.10.800.10; Aaa_hydroxylase; 1.
DR   PANTHER; PTHR11473; Aaa_hydroxylase; 1.
DR   Pfam; PF00351; Biopterin_H; 1.
DR   PRINTS; PR00372; FYWHYDRXLASE.
DR   ProDom; PD002559; Aaa_hydroxylase; 1.
DR   TIGRFAMs; TIGR01269; Tyr_3_monoox; 1.
DR   PROSITE; PS00367; BIOPTERIN_HYDROXYL; 1.
PE   2: Evidence at transcript level;
KW   Catecholamine biosynthesis; Iron; Metal-binding; Monooxygenase;
KW   Neurotransmitter biosynthesis; Oxidoreductase; Phosphoprotein;
KW   Polymorphism.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    495       Tyrosine 3-monooxygenase.
FT                                /FTId=PRO_0000289577.
FT   METAL       328    328       Iron (By similarity).
FT   METAL       333    333       Iron (By similarity).
FT   METAL       373    373       Iron (By similarity).
FT   MOD_RES      19     19       Phosphoserine (By similarity).
FT   MOD_RES      31     31       Phosphoserine (By similarity).
FT   MOD_RES      40     40       Phosphoserine; by PKA (By similarity).
FT   VARIANT      33     33       R -> C.
SQ   SEQUENCE   495 AA;  55679 MW;  D02E3C7784336C7B CRC64;
     MPTPNTASPQ AKGFRRAVSE LDAKQAEAIM SPRFIGRRQS LIEDARKERE KAEAASAASS
     EPGDLLEAAV SKEKDGKAML NLLFTLRGAK TSSLSRAVKA FETFEAQIHH LETRPVQRPR
     AGGPHLEYFV RCEVPSADLP ALLSSVRRVA EDVRGAGENK VLWFPRKVSE LDKCHHLVTK
     FDPDLDLDHP GFSDQVYRQR RKLIAEIAFQ YKHGDPIPRV EYTAEEIATW KEVYTTLKSL
     YVTHACREHL EAFQLLERFS GYREDSIPQL EDVSRFLKER TGFQLRPVAG LLSARDFLAS
     LAFRVFQCTQ YIRHASSPMH SPEPDCCHEL LGHVPMLADR TFAQFSQDIG LASLGASDEE
     IEKLSTLYWF TVEFGLCKQN GEVKAYGAGL LSSYGELLHS LSEEPEIRAF DPDAAAVQPY
     QDQTYQSVYF VSESFSDAKD KLRNYASRIQ RPFSVKFDPY TLAIDVLDSP HAIRRSLEGV
     QDELHTLAHA LSAIG
//