NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 10895 / NRRL Y-1056 / CBS 109.51;
DOI=10.1126/science.1095781; PubMed=15001715 [NCBI, ExPASy, EBI, Israel, Japan]
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.;
"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome.";
Science 304:304-307(2004).

Comments

CATALYTIC ACTIVITY: 3-hydroxyanthranilate + O₂ = 2-amino-3-carboxymuconate semialdehyde.
COFACTOR: Fe(2+) ion (By similarity).
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; pyridine-2,3-dicarboxylate from L-kynurenine: step 3/3 .
SIMILARITY: Belongs to the 3-HAO family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE016816; AAS51101.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_983277.1; -.

3D structure databases

ModBase

Q75CP6.

Organism-specific databases

AGD

ACL127W; -.

Family and domain databases

InterPro

IPR010329; 3hydroanth_dOase.
Graphical view of domain structure.

Pfam

PF06052; 3-HAO; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR03037; anthran_nbaC; 1.

BLOCKS

Q75CP6.

Genome annotation databases

4619397; -.

fig|33169.1.peg.922; -.

Phylogenomic databases

HOGENOM

Q75CP6; -.

Other

ProtoNet

Q75CP6.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 180`	`180`	`3-hydroxyanthranilate 3,4-dioxygenase.`	`PRO_0000245471`
`METAL`	`49 49`		`Iron; catalytic (By similarity).`
`METAL`	`55 55`		`Iron; catalytic (By similarity).`
`METAL`	`98 98`		`Iron; catalytic (By similarity).`
`METAL`	`127 127`		`Divalent metal cation (By similarity).`
`METAL`	`130 130`		`Divalent metal cation (By similarity).`
`METAL`	`164 164`		`Divalent metal cation (By similarity).`
`METAL`	`167 167`		`Divalent metal cation (By similarity).`
`BINDING`	`45 45`		`Dioxygen (By similarity).`
`BINDING`	`55 55`		`Substrate (By similarity).`
`BINDING`	`102 102`		`Substrate (By similarity).`
`BINDING`	`112 112`		`Substrate (By similarity).`

Sequence information

Length: 180 AA [This is the length of the unprocessed precursor]

Molecular weight: 20378 Da [This is the MW of the unprocessed precursor]

CRC64: 24B84FC51F52BA85 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLNTTPINID AWLAENSHLL QPPVNNFCLH RGGFTVMLVG GPNERTDYHV NPTPEWFYQK 

        70         80         90        100        110        120 
TGAMTLRIVD EQLSGAARFR DVTIREGDSF LLPANVPHNP VRYADTVGIV VEQDRPAGHF 

       130        140        150        160        170        180 
DQLRWYCRGC RELVCKYEFY MSDLSSQVRE GIERFAASAE DRVCKHCGTL NYPTPQASAT

Q75CP6 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools