NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 10895 / NRRL Y-1056 / CBS 109.51;
DOI=10.1126/science.1095781; PubMed=15001715 [NCBI, ExPASy, EBI, Israel, Japan]
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.;
"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome.";
Science 304:304-307(2004).

Comments

FUNCTION: Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH (By similarity).
CATALYTIC ACTIVITY: L-2-aminoadipate 6-semialdehyde + NAD(P)⁺ + H₂O = L-2-aminoadipate + NAD(P)H.
COFACTOR: Binds 1 phosphopantetheine covalently (Potential).
PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungi route): step 1/3 .
SUBUNIT: Heterodimer of an alpha and a beta subunit (By similarity).
SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
SIMILARITY: Contains 1 acyl carrier domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE016817; AAS51573.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_983749.1; -.

3D structure databases

ModBase

Q75BB3.

Organism-specific databases

AGD

ADL346W; -.

Family and domain databases

InterPro

IPR010071; AA_adenyl_dom.
IPR000873; AMP-dep_Synth/Lig.
IPR014397; L-NH2adipate-semiAld_DH_lsu.
IPR013120; Male_sterile_NAD-bd.
IPR006163; Phsphopanteth_bd.
IPR006162; Ppantne_S.
IPR010080; Thioester_reductase.
Graphical view of domain structure.

Pfam

PF00501; AMP-binding; 1.
PF07993; NAD_binding_4; 1.
PF00550; PP-binding; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF001617; Alpha-AR; 1.

TIGRFAMs

TIGR01733; AA-adenyl-dom; 1.
TIGR03443; alpha_am_amid; 1.
TIGR01746; Thioester-redct; 1.

PROSITE

PS50075; ACP_DOMAIN; 1.
PS00455; AMP_BINDING; 1.
PS00012; PHOSPHOPANTETHEINE; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q75BB3.

Genome annotation databases

4619884; -.

fig|33169.1.peg.1394; -.

Phylogenomic databases

HOGENOM

Q75BB3; -.

Other

ProtoNet

Q75BB3.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Lysine biosynthesis; NADP; Oxidoreductase; Phosphopantetheine.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 1385`	`1385`	`L-aminoadipate-semialdehyde dehydrogenase large subunit.`	`PRO_0000193148`
`DOMAIN`	`848 917`	`70`	`Acyl carrier.`
`BINDING`	`880 880`		`Phosphopantetheine (covalent) (Potential).`

Sequence information

Length: 1385 AA [This is the length of the unprocessed precursor]

Molecular weight: 152306 Da [This is the MW of the unprocessed precursor]

CRC64: E79042C26C9A9623 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MCAVLEPSMI RWLSEVDNIV VSSLPSDYIP SGPAGVKAES CEVELPGSFG VIDEEDSYIR 

        70         80         90        100        110        120 
LLSAFATLVC RMSGESDVAM YSKANRLLKL AVPPGVAFQQ LRASVTEAVE GTLALPAVDF 

       130        140        150        160        170        180 
DELSALEREK KQLDYYPQYF KVGVVTAADK TKLDQFRYHK FELLLRQVTS SRFEMVYDSE 

       190        200        210        220        230        240 
RFSPDRIGEL GEQLVQFLTL VEAKDDADVY AISLVTSGAS RVLPDPTTDL GWGQFRGAIH 

       250        260        270        280        290        300 
DIFQHHAETR PDRLCVVETG VGQVAARTFT YSAINCASNI VAHYLLARGI RRGDVVMIYS 

       310        320        330        340        350        360 
TRGVDLLVSV LGVLKSGAVF SVIDPAYPPA RQNVYLGVAK PAGLIVIQAA GQLDEAVEAF 

       370        380        390        400        410        420 
IRDNLSLKAR LPALALQTDG AILGGTLPDF HLDTLVPFAS LKNTRTDVVV GPDSNPTLSF 

       430        440        450        460        470        480 
TSGSEGIPKG VLGRHFSLTY YFDWMAKRFG LSEDDKFTML SGIAHDPIQR DMFTPIYLGA 

       490        500        510        520        530        540 
QLLVPQEDDI GTPGRLATWM ATHGATVTHL TPAMGQVLTA DATTPFPSLK RAFFVGDVLT 

       550        560        570        580        590        600 
KRTVHDYSLW LKTWPLLTCT AHLEPSVQYR YFEVQSCCSN PSYLDNVKSI TPAGRGMHNV 

       610        620        630        640        650        660 
QLLIVNRHDR TKLCGIGEVG EIYVRAGGLS EGYRGLPEIN KEKFIDNWFV DAGHWGGLDL 

       670        680        690        700        710        720 
SGDEPWRNYW LGVRDRLYRT GDLGRYLPNG DCECCGRADD QVKIRGFRIE LGEIDTNISQ 

       730        740        750        760        770        780 
YPLCRENITL LRKDQNGEST LISYLVPRSD QKALASFISA VPESIATESI AGSLIKYHKL 

       790        800        810        820        830        840 
INDIRGFLKK RLAGYAIPTL IMVMERLPLN PNGKIDKNKL QFPEPTELDR ASEHFASETL 

       850        860        870        880        890        900 
GLSSFSPLEQ EIRKIWLDLL PTRPAITSSD ESFFDLGGTS ILATRMAIVL RNRLNISLAL 

       910        920        930        940        950        960 
STIFRYPTVK ELAKEISRVR GTISDDKSSN SGTTEYYADA KHVSEAELAS KYESRLSLLP 

       970        980        990       1000       1010       1020 
SGATSAPVYV FLTGVTGFLG CHILADLLNR SRKPYDITVY AHVRASDESS ALQRIKSVCT 

      1030       1040       1050       1060       1070       1080 
AYGLWKNAYA PRIKVVLGNL AEKQFGLPKK AWHDLQEGID VIIHNAALVH WVYPYSKLRE 

      1090       1100       1110       1120       1130       1140 
ANVLSTVNVL NLAAAGKAKY FTFVSSTSAL DTKHYLELSN AAIESGGSGV PEDDDLMGGS 

      1150       1160       1170       1180       1190       1200 
LGLKGGYGQS KWAAEFIIKR AGERGLRGCI LRPGYVTGSP STGASNADDF LLRFLRGCVQ 

      1210       1220       1230       1240       1250       1260 
LGKIPDIEGT VNMVPVDYVA RLATAASFSS SGNTHMMVVN VNAKPRISFR DYLLALKEYG 

      1270       1280       1290       1300       1310       1320 
YQVTSVPYDE WSKALESSSD EENPLYPLLY LVLDDLPKKL RSPELDTTNA KFVLEEDFAR 

      1330       1340       1350       1360       1370       1380 
TNIEPIIITS VSLEVVGSYI SFLHKLGFLE EPAKGSRPLP NISLSDEQIS LIAAVATARS 


STAKP

Q75BB3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools