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[1]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nbt956; PubMed=15064768 [NCBI, ExPASy, EBI, Israel, Japan]
Henne A.,
Brueggemann H.,
Raasch C.,
Wiezer A.,
Hartsch T.,
Liesegang H.,
Johann A.,
Lienard T.,
Gohl O.,
Martinez-Arias R.,
Jacobi C.,
Starkuviene V.,
Schlenczeck S.,
Dencker S.,
Huber R.,
Klenk H.-P.,
Kramer W.,
Merkl R.,
Gottschalk G.,
Fritz H.-J.;
"The genome sequence of the extreme thermophile Thermus thermophilus.";
Nat. Biotechnol. 22:547-553(2004).
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- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP (By similarity).
- CATALYTIC ACTIVITY: NADH + quinone = NAD+ + quinol.
- SUBUNIT: NDH-1 is composed of 15 different subunits, nqo1 to nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits nqo7, nqo8 and nqo10 to nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits nqo1 to nqo6, nqo9 and nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers (By similarity).
- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (Potential).
- SIMILARITY: Belongs to the complex I subunit 1 family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 365 AA [This is the length of the unprocessed precursor] |
Molecular weight: 41009 Da [This is the MW of the unprocessed precursor] |
CRC64: 5B920A702F858C0F [This is a checksum on the sequence] |
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10 20 30 40 50 60
MTWSYPVDPY WMVALKALLV VVGLLTAFAF MTLIERRLLA RFQVRMGPNR VGPFGLLQPL
70 80 90 100 110 120
ADAIKSIFKE DIVVAQADRF LFVLAPLISV VFALLAFGLI PFGPPGSFFG YQPWVINLDL
130 140 150 160 170 180
GILYLFAVSE LAVYGIFLSG WASGSKYSLL GSLRSSASLI SYELGLGLAL LAPVLLVGSL
190 200 210 220 230 240
NLNDIVNWQK EHGWLFLYAF PAFLVYLIAS MAEAARTPFD LPEAEQELVG GYHTEYSSIK
250 260 270 280 290 300
WALFQMAEYI HFITASALIP TLFLGGWTMP VLEVPYLWMF LKLAFFLFFF IWIRATWFRL
310 320 330 340 350 360
RYDQLLRFGW GFLFPLALLW FLVTALVVAL DLPRTYLLYL SALSFLVLLG AVLYTPKPAR
KGGGA
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Q72GD5 in FASTA format |
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