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UniProtKB/Swiss-Prot entry Q724K3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH1_LISMF
Primary accession number Q724K3
Secondary accession numbers None
Integrated into Swiss-Prot on June 7, 2005
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 36)
Name and origin of the protein
Protein name L-lactate dehydrogenase 1
Synonyms L-LDH 1
EC 1.1.1.27
Gene name
Name: ldh1
OrderedLocusNames: LMOf2365_0221
From
Listeria monocytogenes serotype 4b (strain F2365) [TaxID: 265669] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Listeriaceae; Listeria.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1093/nar/gkh562; PubMed=15115801 [NCBI, ExPASy, EBI, Israel, Japan]
Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F., Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D., White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M., Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Haft D.H., Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A., Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O., Luchansky J.B., Fraser C.M.;
"Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species.";
Nucleic Acids Res. 32:2386-2395(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE017262; AAT03008.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_012831.1; -.
3D structure databases
HSSP P16115; 1A5Z. [HSSP ENTRY / PDB]
ModBase Q724K3.
Enzyme and pathway databases
BioCyc LMON265669:LMOF2365_0221-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS Q724K3.
Genome annotation databases
GeneID 2797324; -.
GenomeReviews AE017262_GR; LMOf2365_0221.
KEGG lmf:LMOf2365_0221; -.
TIGR LMOf2365_0221; -.
Phylogenomic databases
HOGENOM Q724K3; -.
Other
ProtoNet Q724K3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   313  313     L-lactate dehydrogenase 1. PRO_0000168363
NP_BIND   13    41  29     NAD (By similarity). 
ACT_SITE   176   176        Proton acceptor. 
BINDING   89    89        Substrate (By similarity). 
BINDING   121   121        NAD or substrate (By similarity). 
BINDING   152   152        Substrate (By similarity). 
BINDING   227   227        Substrate (By similarity). 
MOD_RES   218   218        Phosphotyrosine (By similarity). 
Sequence information
Length: 313 AA [This is the length of the unprocessed precursor] Molecular weight: 34192 Da [This is the MW of the unprocessed precursor] CRC64: B05D3AEFAAADBBB1 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKDHQKIILV GDGAVGSSYA FACVNLSIGQ EFGIIDIDKD RTIGDAMDLS HAVPFSTPKK 

        70         80         90        100        110        120 
IYSANYSDCH DADLVVVTAG TAQKPGETRL DLVNRNIKIM KGIVDEVMAS GFDGIFLIAS 

       130        140        150        160        170        180 
NPVDILTYAT WKFSGLPKER VIGSGTSLDT ARFRMSIADY LKVDARNVHG YILGEHGDTE 

       190        200        210        220        230        240 
FPAWSHTTVG GLPITEWISE DEQGAMDTIF VSVRDAAYEI INKKGATFYG VAAALARITK 

       250        260        270        280        290        300 
AILNNENAIL PLSVYLDGHY GMNDIYIGAP AVVNRQGVRH IVEMNLNDKE KEQMKNSADT 

       310 
LKKVLDDAMK QID
Q724K3 in FASTA format

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